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All Journal Jurnal Komunitas: Jurnal Pengabidian Kepada Masyarakat Journal of Pharmaceutical and Sciences.
Nursoleha, Eva
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Efektivitas Kombinasi Agen Pendeplesi Glutathione (GSH) dan Inhibitor Glutathione S-Transferase (GST) pada Resistensi Cisplatin terhadap Sel Kanker: Systematic Literature Review Nursoleha, Eva; Utami, Wahyu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.777

Abstract

Cisplatin is a platinum-based chemotherapy agent used for the treatment of various types of cancer. However, the use of cisplatin as a chemotherapy agent is limited by drug resistance and side effects due to the formation of inactive metabolites from the conjugation reaction between cisplatin and Glutathione S-Transferase (GST). Thus, Glutathione (GSH) and Glutathione S-Transferase (GST) are essential in controlling cisplatin resistance. This study aims to evaluate the use of a combination of cisplatin with GSH-depleting agents and GST inhibitors to overcome or reduce cisplatin resistance in various cancer cell types in vitro and enhance cisplatin's cytotoxic activity. This research was conducted using a systematic literature review method, with a literature search across two international databases, PubMed and Science Direct, for publications from 2013 to 2024. From 15 selected journals, various GSH-depleting agents and GST inhibitors were found to improve the cytotoxic effects of cisplatin, as analyzed based on data on the levels of GSH and GST in the cells and the percentage of viable cells (% cell viability), which showed a significant decrease. The findings of this study are expected to provide insights into the development of cancer therapies using cisplatin as a chemotherapy agent.
Strategi Menuju Kesejahteraan Berkelanjutan Bagi PMI di Korea Selatan Utami, Wahyu; Purbasari, Heppy; Bawono, Andy Dwi Bayu; Adhianto, Naura Calista Adhianto; Wulandari, Risma Ayunda; Nursoleha, Eva; Andity, Vira Sekar Ayu; Edelwais, Monica; Muthiatulloh, Maryam Dzakiyah; Narda, Anya Cetta; Fadhilah, Faisa Nur
Jurnal Komunitas : Jurnal Pengabdian kepada Masyarakat Vol. 8 No. 1: Juli 2025
Publisher : Institut Ilmu Sosial dan Manajemen Stiami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31334/jks.v8i1.5032

Abstract

Pengabdian kepada Masyarakat ini bertujuan untuk menelaah literasi keuangan di kalangan Pekerja Migran Indonesia (PMI) di Korea Selatan, yang menghadapi berbagai tantangan sosial-ekonomi. Meskipun PMI memiliki potensi untuk memberikan kontribusi besar terhadap ekonomi melalui pengiriman devisa, banyak dari mereka yang mengalami kesulitan dalam pengelolaan keuangan. Metode yang digunakan dalam penelitian ini meliputi survei kebutuhan, edukasi daring dan luring, serta penyuluhan dalam literasi keuangan. Hasil menunjukkan bahwa program literasi ini secara signifikan mampu meningkatkan pemahaman PMI mengenai perencanaan keuangan yang baik. Pendekatan terpadu dalam literasi keuangan sangat vital untuk mendukung keberhasilan adaptasi PMI di Korea Selatan serta meningkatkan kualitas hidup mereka.  
Co-Authors Adhianto, Naura Calista Adhianto Andity, Vira Sekar Ayu Andy Dwi Bayu Bawono Edelwais, Monica Fadhilah, Faisa Nur Heppy Purbasari Muthiatulloh, Maryam Dzakiyah Narda, Anya Cetta Wahyu Utami Wahyu Utami, Wahyu Wulandari, Risma Ayunda