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All Journal PREVENIRE: Journal of Multidisciplinary Science
Intan Dini Maghfiro
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Religion Arts Humanities Computer Science & IT Economics, Econometrics & Finance Education Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Warfarin Review: Anticoagulan Compounds and Its Interactions with Other Drugs Intan Dini Maghfiro; Novia Anggraeni Widiastuti; Yushinta Apriliawati; Deni Ainur Rokhim
Journal of Multidisciplinary Science Vol. 4 No. 2 (2025): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Institut Studi Islam Sunan Doe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58330/prevenire.v4i2.453

Abstract

Blood clots in the body will disrupt human activities. Diseases related to blood activity include blood clots, atrial fibrillation, complications of artificial heart valves, and pulmonary embolism. Treatment that can be done is to take drugs that contain anticoagulants, one of which is warfarin. Method Warfarin is an oral anticoagulant compound that is still often used to prevent blood clots. Warfarin is formed by the synthesis of 4-hydroxycoumarin and benzalacetone. Warfarin inhibits vitamin K synthesis by converting glutamic acid residues to gamma-carboxyglutamic acid residues. However, not all drugs can be taken together with warfarin compounds. There are also some doubtful interactions between warfarin and certain drugs. Warfarin has a narrow therapeutic index so it cannot be given together with several other drugs such as anticonvulsants, NSAIDs , antibiotics, g libenclamide , a miodarone , and statins . It is hoped that with this article, knowledge of warfarin as an anticoagulant will be better in the treatment of diseases caused by blood clots. In this journal, the author uses the literature review method which involves searching and critical analysis of various relevant literary sources, including journal articles, books, and scientific publications related to the topic of discussion.
Co-Authors Deni Ainur Rokhim Novia Anggraeni Widiastuti Yushinta Apriliawati