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All Journal International Journal of Medicine and Health The International Science of Health Journal Green Health: Journal of Health Sciences, Nursing and Nutrition
Akpe C. I.
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Implication of Thrombus Marker (D-Dimer) Levels in Preeclamptic Pregnant Women During the Third Trimester Edebiri O.E; Akpe C. I.; Adewole A.S.; Okike P.I.; Obiesi C. N; Ohiwerei W.O.; Orunta E.D.
The International Science of Health Journal Vol. 3 No. 1 (2025): March : The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v3i1.1765

Abstract

Microvasculature fibrin deposition is implicated in preeclampsia. D-Dimer has emerged as a useful diagnostic tool for thrombotic conditions because its plasma concentration has a high negative implicative value for veinous thromboembolism. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of  twenty (20) normotensive  and twenty (20) preeclamptic pregnant women in their  third trimester of pregnancy. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected  and stored frozen in plain sample bottles and was analyzed for thrombus marker (D- Dimer)  levels  by fluorescence immunoassay  method.   
Implication of Albumin, Microalbumin and Alpha-Feto Protein Variation in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Akpe C. I.; Onwuka K. C.; Ehigiamusoe A. O.; Okike P.I.; Ohiwerei W.O.; Nze P.O
International Journal of Medicine and Health Vol. 4 No. 3 (2025): September : International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.5621

Abstract

The presence of Albumin, Microalbumin and Alpha-Feto Protein increase activity in third trimester. The aims of this study is to determine the Implication of Albumin, Microalbumin and Alpha-Feto Protein Variation in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for liver enzymes (albumin, Microalbumin and Alpha-fetoprotein) levels by fluorescence immunoassay method. . Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in Albumin, Micro albumin were observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as liver dysfunction. These findings suggest albumin and Micro albumin are implicated as potential biomarkers in identifying and monitoring preeclampsia. However, levels of alpha-fetoprotein (AFP) did not show significant differences between preeclamptic and normotensive women.
Assessment of Inflammatory Markers (C - Reactive Protein and High Sensitivity C-Reactive Protein) in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E.; Akpe C. I.; Adewole A.S.; Okike P.I.; Ehigiamusoe E. A.; Ohiwerei W.O.; Omende K.
Green Health International Journal of Health Sciences Nursing and Nutrition Vol. 2 No. 1 (2025): Green Health: International Journal of Health Sciences, Nursing and Nutrition
Publisher : International Forum of Researchers and Lecturers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70062/greenhealth.v2i1.145

Abstract

C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) are general marker for inflammation and Arterial damage results from white blood cell invasion. This study aims to assess the level of inflammatory markers C-Reactive Protein (CRP) and High-Sensitivity C-Reactive Protein (hs-CRP) in preeclamptic pregnant women in the third trimester of pregnancy. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for C-reactive protein (CRP) and high-sensitivity C-reactive protein (hs-CRP) levels by fluorescence immuno assay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in the level of C-Reactive Protein (CRP) and High-Sensitivity C-Reactive Protein (hs-CRP) in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as inflammation.
Co-Authors Adewole A.S. Edebiri O.E Edebiri O.E. Ehigiamusoe A. O. Ehigiamusoe E. A. Nze P.O Obiesi C. N Ohiwerei W.O. Okike P.I. Omende K. Onwuka K. C. Orunta E.D.