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Predictive Role of Angle of Deviation, QRS Complex RVH, LVH and T Wave Amplitudes in Preeclamptic Pregnant Women in The Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Chukwu J.A.O
International Journal of Public Health Vol. 2 No. 1 (2025): March : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i1.326

The use of ECG patterns as predictors of preeclampsia offers a promising approach, as it is a widely available and cost-effective tool. Specific ECG patterns, including angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes as a potential tool for predicting preeclampsia. The aim of this study is to investigate the predictive role of angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show no significant differences were observed in QRS complex angles related to right ventricular hypertrophy (RVH) between normotensive and preeclamptic pregnant women. Notably, there was a significant increase in QRS complex related to left ventricular hypertrophy (LVH) in preeclamptic pregnant women, indicating left ventricular remodeling's importance. Moreover, there was a significant increase in T wave amplitude, this suggests underlying myocardial electrical remodeling or dysfunction in preeclampsia, emphasizing the need for cardiovascular monitoring. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection.

Predictive Role of PR Segment, Q Wave Duration and Amplitude, ST Segment, U Wave and Sinus Rhythm in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Chukwu J.A.O
International Journal of Health and Social Behavior Vol. 2 No. 1 (2025): February: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i1.325

Early detection and prediction of preeclampsia are crucial to prevent severe complications and ensure timely interventions, Specific ECG patterns, including PR segment, Q wave duration and amplitude, ST segment, U wave, and sinus rhythm were under study for their potential indicators of preeclampsia. This study aims to investigate the predictive role of these ECG patterns in preeclamptic pregnant women in the third trimester of pregnancy. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. results from this present study show no significant differences were observed in the P-R segment, R-R interval, Q wave duration, Q wave amplitude The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition, despite parameters showing no significant differences. However, PR Segment, Q Wave duration and amplitude, ST Segment , U wave and Sinus rhythm cannot be used to predict preeclampsia

Implication of Thrombus Marker (D-Dimer) Levels in Preeclamptic Pregnant Women During the Third Trimester Edebiri O.E; Akpe C. I.; Adewole A.S.; Okike P.I.; Obiesi C. N; Ohiwerei W.O.; Orunta E.D.
The International Science of Health Journal Vol. 3 No. 1 (2025): March : The International Science of Health Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Kesdam IV, Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ishel.v3i1.1765

Microvasculature fibrin deposition is implicated in preeclampsia. D-Dimer has emerged as a useful diagnostic tool for thrombotic conditions because its plasma concentration has a high negative implicative value for veinous thromboembolism. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for thrombus marker (D- Dimer) levels by fluorescence immunoassay method.

Predictive Role of P Wave Duration, Amplitudes and P Wave Morphology in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Orunta E.D
International Journal of Health and Medicine Vol. 2 No. 2 (2025): April : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i2.321

The ultimate goal of predicting preeclampsia that can enhance early detection and risk stratification in pregnant women, by leveraging the diagnostic potential of ECG patterns, we hope to improve maternal and fetal outcomes and contribute to the development of personalized care strategies for preeclamptic patients. Current diagnostic methods for preeclampsia rely primarily on routine blood pressure monitoring and proteinuria assessment, which have limited sensitivity and specificity. The aim of this study is to investigate the predictive role of P wave duration, amplitudes and morphology in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show statistically significant increases in P wave duration, amplitude and abnormal M pattern among preeclamptic compare to normotensive pregnant women, consistent with prior research, abnormal M pattern in P wave morphology is linked to atrial pathology in preeclampsia. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition.

Assessment of Brain Injury Marker (Carcinoembryonic Antigen) in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Akpe P. E.; Adewole A.S.; Mbanaso E.L.; Ikuenobe V. E.; Ohiwerei W.O.
International Journal of Health and Medicine Vol. 2 No. 1 (2025): January : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i1.364

Carcinoembryonic antigen (CEA) is a glycoprotein normally produced during fetal development, but presence of tissue damage and inflammation, its levels increase and this may be linked to Carcinoembryonic antigen in the pathophysiology of preeclampsia. This study aims to assess the level of Carcinoembryonic antigen (CEA) in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and 10 milliliters (10 ml) of venous blood was drawn from consenting participants and placed in a lithium heparin sample bottles analyzed for Carcinoembryonic antigen (CEA) levels by fluorescence immunoassay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in the level of Brain injury marker (CEA) was observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as Brain injury in preeclampsia.

Predictive Role Of Oxidative Stress Biomarkers (Malondialdehyde, Glutathione, Catalase and Superoxide Dismutase) in Preeclamptic Pregnant Women In The Third Trimester Of Pregnancy Edebiri O.E; Akpe C. I; Adewole A.S; Onwuka K; Obiesi C. N Nze P.O; Ohiwerei W.O
International Journal of Public Health Vol. 1 No. 4 (2024): December : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i1.365

The predictive role of oxidative stress in the pathophysiology of human pregnancy is of particular interest, as oxidative stress is increased in normotensive pregnant women through systemic inflammatory response, reactive oxygen species (ROS), and reactive nitrogen species (RNS). This study involved 40 consenting pregnant women recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Data obtained were analyzed using GraphPad Prism 9. Results were expressed as mean ± SEM, with a P-value of ≤ 0.05 considered statistically significant. Malondialdehyde (MDA) increased from 3.75 ± 0.42 U/L in normotensive women to 4.53 ± 0.59 U/L in preeclamptic women. However, this increase was not statistically significant (p<0.05; 0.2903). Catalase activity decreased from 114 ± 8.07 U/L in normotensive women to 84.02 ± 21.58 U/L in preeclamptic women, but this decrease was also not statistically significant (p<0.05; 0.1909). Superoxide dismutase (SOD) increased from 40.82 ± 1.23 U/L in normotensive women to 71.90 ± 5.61 U/L in preeclamptic women. This increase was statistically significant (p<0.05; <0.0001). Glutathione peroxidase (GSH) decreased from 66.74 ± 10.35 U/L in normotensive women to 50.63 ± 8.96 U/L in preeclamptic women, but this decrease was not statistically significant (p<0.05; 0.2466). These findings suggest the potential predictive roles of these biomarkers in identifying and monitoring preeclampsia.

Promising Predictors of preeclampsia Creatinine Kinase and Tyrosine Kinase 1 in preeclamptic pregnant women in the third trimester of pregnancy Edebiri O.E; Nwankwo A.A; Akpe P. E; Mbanaso E.I; Onwuka K. C; Ohiwerei W.O; Omende K
International Journal of Health and Social Behavior Vol. 2 No. 2 (2025): May: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i2.366

The potential of cardiac markers in predicting preeclampsia, such as Creatinine Kinase (CK) and Tyrosine Kinase 1 (TK1), has emerged as promising due to their involvement in the pathophysiology of this pregnancy complication. Preeclampsia is characterized by hypertension and organ dysfunction, and it can lead to significant maternal and fetal morbidity if not detected early. Early identification of preeclampsia is critical for preventing severe complications, and biomarkers like CK and TK1 can provide valuable insights. This study aimed to investigate the role of CK and TK1 as potential predictors of preeclampsia in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Participants were divided into two groups: twenty (20) normotensive pregnant women and twenty (20) preeclamptic pregnant women in their third trimester. Blood samples were collected and processed using a bucket centrifuge at 2500 RPM for 10 minutes, and plasma was stored frozen for further analysis. Tyrosine Kinase 1 was analyzed by fluorescence immunoassay, and Creatinine Kinase was measured using a spectrophotometric method. Data obtained were analyzed using GraphPad Prism 9, with results expressed as mean ± SEM. Statistical significance was set at a P-value of ≤ 0.05. The study found a statistically significant increase in the levels of both CK and TK1 in preeclamptic women compared to normotensive controls. These findings suggest that CK and TK1 could serve as predictive biomarkers for identifying and monitoring preeclampsia, aiding in early diagnosis and timely interventions

Evaluation Of Liver Enzymes (ALP, ALT, AST and GGT) in Preeclamptic Pregnant Women in the Third Trimester Of Pregnancy Edebiri O.E; Adewole A.S; Akpe C. I; Ehigiamusoe E. A; Ikuenobe V. E; Ohiwerei W.O; Orunta E.D
International Journal of Medicine and Health Vol. 4 No. 1 (2025): International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v4i1.5618

Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspartate Transaminase (AST), and Gamma-Glutamyl Transferase (GGT) are liver enzymes commonly associated with liver dysfunction, and increased or decreased levels of these enzymes may be implicated in the pathophysiology of preeclampsia. This study aims to evaluate the levels of liver enzymes (ALP, ALT, AST, and GGT) in preeclamptic pregnant women in the third trimester of pregnancy. By analyzing these enzymes, the research seeks to identify potential early indicators of preeclampsia. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples were spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes, after which plasma was collected and stored frozen in plain sample bottles to be analyzed for liver enzymes (ALP, ALT, AST, and GGT) levels using the spectrophotometric method. Data obtained from the study were analyzed using Graph Pad Prism 9. Results were expressed as mean ± SEM, and a P-value of ≤ 0.05 was considered statistically significant. The present study showed a statistically significant increase in ALP, and a statistically significant decrease in liver enzymes such as ALT and AST were observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as liver dysfunction.

Implication of Albumin, Microalbumin and Alpha-Feto Protein Variation in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Akpe C. I.; Onwuka K. C.; Ehigiamusoe A. O.; Okike P.I.; Ohiwerei W.O.; Nze P.O
International Journal of Medicine and Health Vol. 4 No. 3 (2025): September : International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.5621

The presence of Albumin, Microalbumin and Alpha-Feto Protein increase activity in third trimester. The aims of this study is to determine the Implication of Albumin, Microalbumin and Alpha-Feto Protein Variation in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for liver enzymes (albumin, Microalbumin and Alpha-fetoprotein) levels by fluorescence immunoassay method. . Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in Albumin, Micro albumin were observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as liver dysfunction. These findings suggest albumin and Micro albumin are implicated as potential biomarkers in identifying and monitoring preeclampsia. However, levels of alpha-fetoprotein (AFP) did not show significant differences between preeclamptic and normotensive women.

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