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All Journal Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Mathematics and Natural Sciences
Hidayat, Nafisa Nurfatia
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Computer Science & IT Medicine & Pharmacology Other

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Lawsonia inermis: Review of Its Anti-inflammatory Properties and Therapeutic Potential Hidayat, Nafisa Nurfatia; Musfiroh, Ida
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.58785

Abstract

Lawsonia inermis often referred to as henna has been utilized for millennia in many parts of the world in traditional medicine including antibacterial, antifungal, antioxidant, anticancer and immunomodulatory effects and also to treat various inflammatory conditions. This review aims to comprehensively evaluate the anti-inflammatory effects of L. inermis and its potential therapeutic applications. Primary methods included literature searches in scientific databases like PubMed, Scopus, Springer that analyzed the bioactive compounds and their effects on inflammation. L. inermis contains active compounds like lawsone, alkaloids, flavonoids, and tannins, which have been shown to reduce inflammation in various experimental settings by inhibiting the production of pro-inflammatory such as cytokines and enzymes. Studies conducted in vivo and in vitro have shown that effectivity of Lawsonia inermis is effective in lowering edema, healing wounds, and both acute and chronic inflammation which involve regulatory mechanism and mediators of inflammation signalling pathways. Promising outcomes in the treatment of contact dermatitis, wound healing, reduce symptoms and pain management have also been seen in clinical studies. L. inermis shows promise as a natural anti-inflammatory agent. However, further research is needed to fully understand its mechanisms of action and optimize its therapeutic applications, including investigating its potential interactions with other medications and identifying the optimal dosage and administration routes.
Studi in Silico Senyawa Metabolit Sekunder Daun Kenikir (Cosmos Caudatus Kunth.) Sebagai Antikanker Ovarium terhadap ESR-1 Gabriel, Kevin; Hidayat, Nafisa Nurfatia; Khaerani, Fitri Azlia; Gaharani , Prodio Efa
Indonesian Journal of Mathematics and Natural Sciences Vol. 47 No. 2 (2024): Volume 47 Nomor 2 Tahun 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/s43fsj13

Abstract

Ovarian cancer is one of the diseases with a high mortality rate through estrogen receptor alpha (ESR1) as one of the causes of ovarian cancer. Current therapies for ovarian cancer can cause side effects and are expensive. Therefore, alternative therapies with fewer side effects and more affordable costs are needed.  One of the herbs that is rich in flavonoid and phenolic acid content which has anticancer activity with its mechanism as a trigger for apoptosis in ovarian cancer cells is Kenikir leaf (Cosmos caudatus). The study was conducted through pharmacophore screening and molecular docking methods in silico with ESR-1 receptor (PDB code:1SJ0). In addition, absorption, distribution, and toxicity predictions were also carried out through the PreADMET page and the Lipinski Rule of Five suitability test. The results of this study concluded that luteolin is the most potential compound as an ESR-1 receptor inhibitor with a pharmacophore fit-score value of 51.36, binding energy of -8.43 kcal/mol, inhibition constant of 66.366x10-2 µM, and hydrogen bonds as ligand-receptor interactions.
Co-Authors Gabriel, Kevin Gaharani , Prodio Efa Ida Musfiroh, Ida Khaerani, Fitri Azlia