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All Journal Pharmacology and Clinical Pharmacy Research Indonesian Journal of Mathematics and Natural Sciences
Khaerani, Fitri Azlia
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Medicine & Pharmacology Other

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Effectiveness of Cognitive-behavioral Therapy for Generalized-Anxiety Disorders in Adolescents: A Systematic Review Using PICO Framework Suryanto, Rajwa Dwifauza; Gaharani, Prodio Efa; Salsabila, Salma; Finola Aziz, Calista Sasikirana; Khaerani, Fitri Azlia; Athaya, Salsabila; Setyowati, Lulu Alya; Kartadikaria, Elisya; Djamaluddin, Muhammad Ilham; Soewahju, Renata Bella Aprilana; Pitaloka, Dian Ayu Eka
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.53373

Abstract

A number of teenagers experience various levels of mental disorders, ranging from mild stress to Generalized Anxiety Disorder (GAD). According to the World Health Organization (WHO), approximately 264 million people suffer from anxiety disorders, including GAD, and this condition is a significant leading cause of suicide incidents, ranking sixth among serious mental health issues. From a societal perspective, Cognitive Behavioral Therapy (CBT) has the advantage of cost-effectiveness by minimizing the use of medications and enhancing productivity in education for adolescents receiving CBT. This study aims to conduct a systematic review of the existing literature on GAD in adolescents, using the PICO format method and formulating relevant research questions (RQ). Based on research that has been done, CBT has a relevant effect on some cases of GAD experienced by adolescents, although in some conditions CBT needs to be combined with antidepressants.
Studi in Silico Senyawa Metabolit Sekunder Daun Kenikir (Cosmos Caudatus Kunth.) Sebagai Antikanker Ovarium terhadap ESR-1 Gabriel, Kevin; Hidayat, Nafisa Nurfatia; Khaerani, Fitri Azlia; Gaharani , Prodio Efa
Indonesian Journal of Mathematics and Natural Sciences Vol. 47 No. 2 (2024): Volume 47 Nomor 2 Tahun 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/s43fsj13

Abstract

Ovarian cancer is one of the diseases with a high mortality rate through estrogen receptor alpha (ESR1) as one of the causes of ovarian cancer. Current therapies for ovarian cancer can cause side effects and are expensive. Therefore, alternative therapies with fewer side effects and more affordable costs are needed.  One of the herbs that is rich in flavonoid and phenolic acid content which has anticancer activity with its mechanism as a trigger for apoptosis in ovarian cancer cells is Kenikir leaf (Cosmos caudatus). The study was conducted through pharmacophore screening and molecular docking methods in silico with ESR-1 receptor (PDB code:1SJ0). In addition, absorption, distribution, and toxicity predictions were also carried out through the PreADMET page and the Lipinski Rule of Five suitability test. The results of this study concluded that luteolin is the most potential compound as an ESR-1 receptor inhibitor with a pharmacophore fit-score value of 51.36, binding energy of -8.43 kcal/mol, inhibition constant of 66.366x10-2 µM, and hydrogen bonds as ligand-receptor interactions.
Co-Authors Athaya, Salsabila Djamaluddin, Muhammad Ilham Finola Aziz, Calista Sasikirana Gabriel, Kevin Gaharani , Prodio Efa Gaharani, Prodio Efa Hidayat, Nafisa Nurfatia Kartadikaria, Elisya Pitaloka, Dian Ayu Eka Salsabila, Salma Setyowati, Lulu Alya Soewahju, Renata Bella Aprilana Suryanto, Rajwa Dwifauza