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All Journal International Journal of Health and Pharmaceutical (IJHP) Jurnal Wahana Akuntansi: Sarana Informasi Ekonomi dan Akuntansi
Indriani, Intan
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Economics, Econometrics & Finance Education Nursing Public Health

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Stage-Specific Pathological Features of Chronic Kidney Disease: An Article Review Indriani, Intan; Dwi Nopriansyah, Wely; Ishak Hutasoit, Januar; Ikram Zakaria, M.
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.402

Abstract

Chronic Kidney Disease (CKD) is a major global health challenge, with increasing prevalence, particularly in developing countries. CKD is characterized by a gradual and irreversible decline in kidney function, often progressing to End-Stage Renal Disease (ESRD). The pathophysiology of CKD involves structural and functional deterioration in various renal compartments, including the glomerulus, tubules, interstitial tissue, and blood vessels. Histopathological changes play a critical role in disease progression, with interstitial fibrosis, glomerulosclerosis, and tubular atrophy being the hallmark lesions observed across different CKD stages. This review highlights the anatomical pathology of CKD at various stages, focusing on histopathological changes, diagnostic techniques, and factors influencing disease progression. Renal biopsy remains the gold standard for assessing kidney damage, utilizing special stains such as Periodic Acid-Schiff (PAS) to identify fibrosis and sclerosis. However, noninvasive biomarkers like Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) have emerged as promising tools for early detection. Studies indicate that histopathologic findings, including interstitial fibrosis and glomerulosclerosis, often correlate with CKD progression more accurately than estimated glomerular filtration rate (eGFR) alone. This review underscores the need for integrating histopathological, clinical, and molecular biomarkers to improve CKD diagnosis and management. A better understanding of kidney pathology can facilitate early detection, refine prognostic assessments, and enhance treatment strategies. Future research should focus on noninvasive diagnostic alternatives and novel therapeutic targets to slow CKD progression and mitigate its global health burden.
Pengaruh Struktur Aktiva dan Struktur Modal terhadap Harga Saham Pada PT Aneka Tambang (Persero) Tbk Indriani, Intan; Ramdhani, Abdullah; Rosmayati, Irma
Jurnal Wahana Akuntansi Vol 5 No 2 (2020): Jurnal Wahana Akuntansi
Publisher : Fakultas Ekonomi Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jwa.v5i2.2025

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh struktur aktiva dan struktur modal terhadap harga saham periode tahun 2013 sampai dengan 2018. Peneliti menggunakan data sekunder, yaitu laporan keuangan tahunan PT Aneka Tambang (Persero) yang terdaftar di bursa efek indonesia. Metode yang digunakan dalam penelitian ini adalah metode asosiatif. Teknik pengumpulan data yaitu  penelitian kepustakaan dan penelitian dokumentasi. Teknik pengolahan data dilakukan dengan menggunakan analisis regresi linier berganda melalui uji F dan uji t serta pengujian asumsi klasik. Penelitian ini menggunakan software SPSS 23. Hasil penelitian menunjukan bahwa secara simultan struktur aktiva dan struktur modal berpengaruh signifikan terhadap harga saham, sedangkan secara parsial struktur aktiva tidak memiliki pengaruh negatif tidak signifikan terhadap harga saham. Kemudian struktur modal tidak memiliki pengaruh positif tidak signifikan terhadap harga saham.
Co-Authors Abdullah Ramdhani Dwi Nopriansyah, Wely Ikram Zakaria, M. Ishak Hutasoit, Januar Rosmayati, Irma