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Latifa, Ainun
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Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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BASIC PSYCHOLOGICAL NEED IS EFFECTIVE AS A MEDIATOR IN IMPROVING THE RELATIONSHIP BETWEEN SCHOOL CLIMATE AND STUDENT ENGAGEMENT IN ELEMENTARY SCHOOL STUDENTS Latifa, Ainun; Mardianto, Mardianto
Jurnal RAP (Riset Aktual Psikologi Universitas Negeri Padang) Vol 15, No 2 (2024)
Publisher : Universitas Negeri Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/rapun.v15i2.130252

Abstract

This study aims to see how the contribution of school climate and the fulfillment of basic psychological needs to student engagement in elementary school students in Agam district.  This study uses quantitative methods. Student engagement was measured using School Engagement Measure (SEM)- MacArthur with a reliability of 0.869, Comprehensive School Climate Inventory with a reliability of 0.860, and Basic Psychological Needs in the Classroom Scale (BPN-CS) with a reliability of 0.832. The sampling technique in this study used cluster random sampling with a total of 138 elementary students in Agam district. Multiple linear regression analysis is the analytical technique used in this study. The results of this study showed a significance value (p) of 0.00 <0.05, these results indicate that school climate and basic psychological needs simultaneously contribute to student engagement in elementary school students in Agam district. The contribution given is as much as 49.7%. School climate and basic psychological need separately also show a contribution to student engagement, and school climate shows a higher contribution than basic psychological need
EKSPLORASI POTENSI SENYAWA BAHAN ALAM SEBAGAI KANDIDAT ANTIKANKER PARU MELALUI PENDEKATAN MOLECULAR DOCKING: SUATU TINJAUAN LITERATUR latifa, Ainun; Saeful Amin
Journal of Public Health Science Vol. 2 No. 3 (2025): September
Publisher : Yayasan Nuraini Ibrahim Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70248/jophs.v2i3.3136

Abstract

Kanker paru masih menjadi salah satu penyebab utama kematian akibat kanker di seluruh dunia, dengan karakteristik heterogenitas molekuler yang kompleks serta munculnya resistensi terhadap berbagai terapi konvensional. Sumber daya alam diketahui mengandung beragam senyawa bioaktif yang berpotensi dikembangkan sebagai agen antikanker. Kemajuan teknologi komputasi, khususnya molecular docking, menghadirkan peluang baru dalam mengungkap interaksi senyawa alami dengan protein target pada kanker paru secara lebih efisien, cepat, dan hemat biaya. Artikel tinjauan literatur ini bertujuan menelaah penelitian-penelitian yang mengkaji potensi senyawa alam terhadap target kanker paru melalui pendekatan molecular docking. Proses penelusuran dilakukan pada basis data PubMed, ScienceDirect, dan Google Scholar dengan cakupan publikasi tahun 2015–2025. Berdasarkan hasil kajian, sejumlah senyawa seperti piperlongumine, artocarpin, antosianin, dan nordamnacanthal terbukti memiliki afinitas ikatan yang tinggi terhadap target molekuler penting, antara lain EGFR, PDGFR-α, PTGS2, dan PPARG. Nilai skor docking yang tinggi menunjukkan potensi aktivitas biologis, meskipun tetap membutuhkan verifikasi lanjutan melalui penelitian in vitro maupun in vivo. Dengan demikian, molecular docking dapat dipandang sebagai langkah awal yang krusial dalam eksplorasi obat berbasis bahan alam untuk terapi kanker paru serta menjadi fondasi bagi pengembangan kandidat obat baru di masa mendatang.
Co-Authors Mardianto Mardianto Saeful Amin