Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention JPSCR : Journal of Pharmaceutical Science and Clinical Research
Siagian, Virginia Heaven Mariboto
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Prediction of Secondary Metabolite Compounds in Lotus (Nelumbo nucifera Gaertn.) Targeting Androgen-α Receptors for Breast Cancer Treatment Using Molecular Docking Siagian, Virginia Heaven Mariboto; Destia, Melsa; Andini, Nasywa Putri; Yustiandini, Benedicta Andrea; Adhinagoro, Bagus; Salsabila, Shela; Muchtaridi, Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp137-149

Abstract

Breast cancer (BC) is a malignant tumor that grows in the breast tissue and can spread to other organs. BC is often found at an advanced stage and therefore has a poor prognosis. With 68,858 cases, BC is the most common type of cancer in Indonesia. The development of breast carcinoma is strongly influenced by steroid hormones and their receptors, such as estrogen, progesterone, and androgen. Androgen receptors (AR) are found more (70-90%) compared to estrogen receptors (60-80%) and progesterone receptors (50-70%). Therefore, research on natural compounds that inhibit cancer cell proliferation influenced by AR needs to be increased. The lotus plant (Nelumbo nucifera Gaertn.) has been used as a traditional herbal medicine and food in Asia. Bioactive compounds in lotus have therapeutic potential against BC. In the pharmacophore screening results, five hit compounds were found: isorhamnetin, luteolin, catechin, kaempferol, and apigenin. The compound with the best pharmacophore fit score value is isorhamnetin with a value of 41.31, while the compound with the best binding affinity to AR is kaempferol with a binding affinity of -9.44 and an inhibitor constant of 121.12 nM.Keywords: breast-cancer, androgen-α receptor, lotus, molecular docking.
Formulation of Small Quantity Lipid-based Nutrient Supplement (SQ-LNS) Tablet from Soybean: A Preventive Approach on Stunted Birth for Pregnant and Breastfeeding Women Siagian, Virginia Heaven Mariboto; Cung, Johnessa; Anandawijaya, Spica Diani; Febriliani, Sandya Amelia; Widyapuspita, Avika; Sopyan, Iyan
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.91338

Abstract

The prevalence of stunting in Indonesia, which has not met the requirements of the WHO, makes stunting a national problem. In line with the nutritional intervention in 2020-2030, UNICEF developed SQ-LNS products as a food paste. As an effort to prevent stunting as well as improve product stability, the formulation of Small-Quantity Lipid-based Nutrient Supplements (SQ-LNS) from soybeans (Glycine max (L.) Merr) in tablet form is proposed to be a solution for pregnant and breastfeeding women. Microencapsulation technology is used to entrap soybean oil as the lipid source of this supplement. This study aims to obtain the best concentration of maltodextrin, soy protein isolate, and carboxymethyl cellulose as a soybean oil coating for felting into SQ-LNS tablet preparation. The best microcapsule is produced from a 40% formula with a percent yield of 28%, encapsulation efficiency of 79.83%, PSD microcapsule of 1.003 μm, and round agglomerated particles with a smooth surface without any residual oil seen under the SEM, and obtained the best formulation and evaluation of SQ-LNS tablets so that they meet the quality standards of good stunting supplement tablets.
Co-Authors Adhinagoro, Bagus Anandawijaya, Spica Diani Andini, Nasywa Putri Cung, Johnessa Destia, Melsa Febriliani, Sandya Amelia Iyan Sopyan Muchtaridi Muchtaridi Salsabila, Shela Widyapuspita, Avika Yustiandini, Benedicta Andrea