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All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M)
Salsabila, Shela
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Biochemistry, Genetics & Molecular Biology Education Medicine & Pharmacology Social Sciences

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Prediction of Secondary Metabolite Compounds in Lotus (Nelumbo nucifera Gaertn.) Targeting Androgen-α Receptors for Breast Cancer Treatment Using Molecular Docking Siagian, Virginia Heaven Mariboto; Destia, Melsa; Andini, Nasywa Putri; Yustiandini, Benedicta Andrea; Adhinagoro, Bagus; Salsabila, Shela; Muchtaridi, Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp137-149

Abstract

Breast cancer (BC) is a malignant tumor that grows in the breast tissue and can spread to other organs. BC is often found at an advanced stage and therefore has a poor prognosis. With 68,858 cases, BC is the most common type of cancer in Indonesia. The development of breast carcinoma is strongly influenced by steroid hormones and their receptors, such as estrogen, progesterone, and androgen. Androgen receptors (AR) are found more (70-90%) compared to estrogen receptors (60-80%) and progesterone receptors (50-70%). Therefore, research on natural compounds that inhibit cancer cell proliferation influenced by AR needs to be increased. The lotus plant (Nelumbo nucifera Gaertn.) has been used as a traditional herbal medicine and food in Asia. Bioactive compounds in lotus have therapeutic potential against BC. In the pharmacophore screening results, five hit compounds were found: isorhamnetin, luteolin, catechin, kaempferol, and apigenin. The compound with the best pharmacophore fit score value is isorhamnetin with a value of 41.31, while the compound with the best binding affinity to AR is kaempferol with a binding affinity of -9.44 and an inhibitor constant of 121.12 nM.Keywords: breast-cancer, androgen-α receptor, lotus, molecular docking.
Pemanfaatan Sawi Putih menjadi Produk “JASIJO” dan “BRASSICA ICE” untuk Meningkatkan Ekonomi Masyarakat Setiawan, Eko; Firdaus, Muhammad Zuhuuron; Abdi, Fiqi Nur; Saputri, Aslina Afi; Ita, Nur; Rahmawati, Dewi; Az’zah, Annis; Hafifah, Sriyati; Wahyuni, Ira; Zakiyah, Dewi; Salsabila, Shela
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 3 No. 1 (2022)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v3i1.16175

Abstract

Pembuatan produk stik dan ice dari sawi putih merupakan upaya pemanfaatan sayuran yang dijadikan sebuah produk untuk mengolah sawi yang tidak terjual supaya tidak membusuk, sekaligus untuk meningkatkan pendapatan warga. Desa Pujon Kidul RT 04 mayoritas warganya menanam sayuran sawi putih, karena warga mengeluh mengenai rendahnya harga sawi putih dan kurangnya pengetahuan tentang pengelolaan sawi putih yang dapat menghasilkan produk yang bernilai, untuk itu kami berinisiatif melakukan uji coba pembuatan produk dari sawi putih berupa jajanan stik dan ice cream. Produk stik dan ice cream yang sudah jadi dan telah memenuhi standar pengedaran atau untuk dikonsumsi, bisa dijual untuk menambah pendapatan masyarakat. Metode yang digunakan adalah wawancara, persiapan, praktik lapangan, evaluasi, revisi produk dan penyuluhan. Hasil dari penyuluhan yaitu, ibu RT akan mengkoordinasi kepada warga setempat dan akan melakukan praktek pembuatan produk stik dan ice cream, dimana kebanyakan warga mengalami kesulitan dalam memanfaatkan sawi putih yang tidak terjual melalui pembuatan produk tersebut. Sehingga dengan adanya kegiatan ini masyarakat dapat menciptakan produk baru, beda dan berkelanjutan dengan tujuan untuk membantu menambah pemasukan.
In Silico Study of Torch Ginger Flower (Etlingera elatior (Jack) R.M.Sm. flos) Bioactive Compounds Targeting TGF-β Receptor Type I (TGF-βR1) as Potential Tumor Suppressor Agents Yuarsa, Yohana Faustine; Putri, Garneta Izzati Herdy; Sanjaya, Valeri Belliana; Rahman, Akmal Taufiqur; Salsabila, Shela; Fauzan, Nawadhir; Muchtaridi, Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 16, No 1 (2025)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev16iss1pp15-28

Abstract

Cancer remains one of the leading causes of death worldwide, with an estimated 16.3 million cancer-related deaths projected by 2040. Current cancer therapies still face various challenges such as resistance, toxicity, and high costs, highlighting the need for more targeted approaches in the discovery of new therapies. Torch ginger flower (Etlingera elatior (Jack) R.M.Sm. flos) has been reported to contain bioactive compounds with potential tumor-suppressive activities through modulation of cancer-related pathways. However, in silico evidence evaluating its active compounds as potential inhibitors of transforming growth factor-beta receptor type I (TGF-βR1), a protein involved in tumor proliferation and metastasis remains limited. This study aimed to predict and evaluate the potential of Etlingera elatior compounds as tumor-suppressing agents targeting TGF-βR1 using computational approaches. Lipinski’s Rule of Five and ADME-Tox predictions were performed to assess drug-likeness and pharmacokinetic properties, while pharmacophore screening and molecular docking were conducted to identify hit compounds and predict their binding affinities. Among the tested compounds, kaempferol and quercetin showed the highest pharmacophore fit scores (47.21% and 47.07%, respectively) and the best binding affinities to TGF-βR1 (-7.98 kcal/mol; Ki 1.42 μM for kaempferol and -7.87 kcal/mol; Ki 1.72 μM for quercetin), and although their binding poses were not the most similar to the reference inhibitor LY3200882 (-8.39 kcal/ mol; Ki 0.71 μM), the consistent alignment of favorable pharmacophore fit and binding energy still reinforces their potential. These findings indicate that kaempferol and quercetin have promising potential as candidate natural tumor-suppressive agents targeting TGF-βR1.Keywords: Cancer, TGF-βR1, Torch Ginger Flower, Molecular Docking.
Co-Authors Abdi, Fiqi Nur Adhinagoro, Bagus Andini, Nasywa Putri Az’zah, Annis Destia, Melsa DEWI RAHMAWATI Eko Setiawan Fauzan, Nawadhir Firdaus, Muhammad Zuhuuron Hafifah, Sriyati Muchtaridi Muchtaridi Nur Ita Putri, Garneta Izzati Herdy Rahman, Akmal Taufiqur Sanjaya, Valeri Belliana Saputri, Aslina Afi Siagian, Virginia Heaven Mariboto Yuarsa, Yohana Faustine Yustiandini, Benedicta Andrea Zakiyah, Dewi