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All Journal Indonesian Journal of Medicine Journal of Health Promotion and Behavior
Zahra, Fathia Mutiara
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Medicine & Pharmacology Public Health

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Meta Analysis the Effect of Cadmium Exposure on Chronic Renal Filure in Adults Zahra, Fathia Mutiara; Rahardjo, Setyo Sri; Murti, Bhisma
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Heavy metals, such as cadmium, are heavy metals that are hazardous to health. Chronic exposure to cadmium is associated with decreased glomerular filtration rate and increased risk of chronic renal failure. This study was conducted to determine how much influence cadmium exposure has on the incidence of chronic kidney failure in adults. The purpose of this study was to analyze the effect of cadmium exposure on the incidence of chronic kidney failure in adults.Subject and Method: This study is a systematic review and meta-analysis using the PRISMA flowchart with PICO as follows, Population: Adults. Intervention: Exposure to Cadmium. Compa­rison: No Cadmium Exposure. Outcome: Chronic Renal Failure. Search articles using several data­bases including PubMed, Google Scholar, and Science Direct with the search keywords “adults” AND “cadmium exposure” AND “chronic kidney failure”. The articles submitted ranged from 2013 to 2021. Analysis was performed using RevMan 5.3 as a statistical program.Results: There are 11 articles, originating from the continents of Asia and Europe. The results of the meta-analysis showed that exposure to cadmium increased the risk of developing chronic renal failure in adults by 2.81 times compared with adults who were not exposed to cadmium and was statistically significant (aOR = 2.81; 95% CI = 1.74 to 4.51; p < 0.001).Conclusion: Cadmium exposure may increase the risk of chronic kidney failure in adults.Keywords: cadmium, chronic renal failure, adultsCorrespondence: Fathia Mutiara Zahra. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: efemzahra31@student.uns.ac.id. Mobile: +62 815-6798-7661.Indonesian Journal of Medicine (2022), 07(01): 61-72https://doi.org/10.26911/theijmed.2022.07.01.07
Meta-analysis Effect of Compliance with Folic Acid Supplement Consumption in Pregnant Women on the Risk of Birth Defects Zahra, Fathia Mutiara; Winahyu, Frannesty Estu; Murti, Bhisma
Journal of Health Promotion and Behavior Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Low concentrations of folic acid supplement intake during pregnancy can cause birth defects in the baby. Therefore, this study was conducted to identify those associated with adherence to folic acid supplement consumption in pregnant women and provide a shadow for further research. The purpose of this study was to investigate the effect of birth defects and pregnant women's adherence to taking folic acid supplements during pregnancy.Subjects and Method: This study uses the PRISMA flowchart to perform the meta-analysis. The article review process took place between 2017 and 2022 with PICO as follows, Population: Pregnant Women. Intervention: Folic acid consumption before and during pregnancy, Comparison: no folic acid consumption before and during pregnancy, Outcome: risk of birth defects, articles collected using databases such as PubMed, Google Scholar, and Science Direct used. The articles obtained will be filtered using the stages according to the PRISM flow diagram. The analysis was carried out using RevMan 5.3.Results: A total of 9 articles, including 6 articles from the Asian continent, namely China, Japan, India, and Bangladesh, 2 articles from the Americas, namely Mexico and New York, and 1 from the African continent, namely Ethiopia. Wherefrom the meta-analysis of 9 articles, it is known that adherence to folic acid supplementation can reduce the risk of birth defects in pregnant women (aOR= 0.69; 95% CI= 0.50 to 0.96; p= 0.003).Conclusion: Adherence to folic acid supplementation can help reduce the risk of birth defects in pregnant women.Keywords: pregnant women, folic acid, birth defects.Correspondence:Fathia Mutiara Zahra. Study Program of Pharmacy, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: efemzahra31@student.uns.ac.id. Mobile: +62815-67987661.Journal of Health Promotion and Behavior (2022), 07(02): 97-107DOI: https://doi.org/10.26911/thejhpb.2021.07.02.02
Co-Authors Bhisma Murti Rahardjo, Setyo Sri Winahyu, Frannesty Estu