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All Journal International Journal Multidisciplinary
Dimas Alamanda, Vidiana
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Education Environmental Science Languange, Linguistic, Communication & Media Medicine & Pharmacology Physics

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REVIEW: DEVELOPMENT OF NATURAL MATERIALS AS BREAST CANCER ANTICANCER Kaniawati, Marita; Cintiya Dewi , Silvy; Azzah Wulandari, Yulinda; Dimas Alamanda, Vidiana
International Journal Multidisciplinary (IJMI) Vol. 2 No. 1 (2025): International Journal Multidisciplinary
Publisher : Antis-Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/ijmi.v2i1.280

Abstract

Objective: This study aims to review various efforts in developing anticancer therapies based on medicinal plants and synthetic compounds, particularly for breast cancer, which has high prevalence and mortality rates. Method: Data were collected through a literature review of scientific journals published between 2010 and 2020. The study analyzed the potential of various medicinal plants and bioactive compounds using both experimental and computational approaches.  Results: The review revealed that medicinal plants such as soursop leaves, galangal, moringa leaves, Kasumba Turate flowers, and red dragon fruit peels exhibit significant anticancer potential. Their activities include cytotoxicity, proliferation inhibition, and apoptosis induction in T47D and MCF-7 breast cancer cells. Additionally, an in silico approach was employed to evaluate bioactive compounds like galangin and quercetin, which demonstrated potential interactions with specific molecular targets such as HER-2 and SIRT1. Novelty: This study highlights the importance of exploring both natural and synthetic anticancer compounds to develop more effective and safer therapies. The integration of in silico analysis provides a deeper understanding of molecular interactions, supporting the advancement of targeted breast cancer treatments.
Co-Authors Azzah Wulandari, Yulinda Cintiya Dewi , Silvy Marita Kaniawati