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All Journal International Journal of Health and Medicine Green Health: Journal of Health Sciences, Nursing and Nutrition
Mbanaso E.L.
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Health Professions Medicine & Pharmacology Nursing Public Health

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Assessment of Brain Injury Marker (Carcinoembryonic Antigen) in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Akpe P. E.; Adewole A.S.; Mbanaso E.L.; Ikuenobe V. E.; Ohiwerei W.O.
International Journal of Health and Medicine Vol. 2 No. 1 (2025): January : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i1.364

Abstract

Carcinoembryonic antigen (CEA) is a glycoprotein normally produced during fetal development, but presence of tissue damage and inflammation, its levels increase and this may be linked to Carcinoembryonic antigen in the pathophysiology of preeclampsia. This study aims to assess the level of Carcinoembryonic antigen (CEA) in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and 10 milliliters (10 ml) of venous blood was drawn from consenting participants and placed in a lithium heparin sample bottles analyzed for Carcinoembryonic antigen (CEA) levels by fluorescence immunoassay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in the level of Brain injury marker (CEA) was observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as Brain injury in preeclampsia.
Promising Markers of Preeclampsia : Cardiac Troponin 1 and Brain Natriuretic Peptide in Third Trimester Pregnant Women Edebiri O.E.; Nwankwo A. A.; Akpe P. E.; Mbanaso E.L.; Ikuenobe V. E.; Omende K.; Ohiwerei W.O
Green Health International Journal of Health Sciences Nursing and Nutrition Vol. 2 No. 2 (2025): Green Health: International Journal of Health Sciences, Nursing and Nutrition
Publisher : International Forum of Researchers and Lecturers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70062/greenhealth.v2i2.143

Abstract

Cardiac Troponin1 (cTn1) is a protein released into the bloodstream following cardiac damage and Brain Natriuretic Peptide (BNP) is a hormone released by the heart in response to ventricular stretch and pressure overload. This study aims to investigate the predictive role of cTn1 and BNP in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for Cardiac Troponin 1(cTn1) and Brain Natriuretic Peptide (BNP) by fluorescence immunoassay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in Brain Natriuretic Peptide (BNP) in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes. These findings suggest the potential predictive roles of this cardiac marker in identifying and monitoring preeclampsia.
Co-Authors Adewole A.S. Akpe P. E. Edebiri O.E Edebiri O.E. Ikuenobe V. E. Nwankwo A. A. Ohiwerei W.O Ohiwerei W.O. Omende K.