Background: HIV/AIDS is a disease that can cause death and not only affects the physical well-being of an individual but also the overall quality of life, namely psychological, social, and spiritual for someone who is infected. One effort that can be given is to design support and care for PLWHA to improve the quality of life of PLWHA. Purpose: The purpose of this article is to identify factors related to medication adherence that can affect the quality of life of PLWHA. Method: This study is an observational study using a cross-sectional approach. A total of 64 respondents filled out a sociodemographic data questionnaire and WHOQOL-HIV BREF to measure quality of life. The relationship between quality of life and the sociodemographic characteristics of respondents was analyzed using the Kruskal-Wallis and Mann-Whitney U tests. Result: Physical domain of QOL showed a maximum score of 15.41 and social relationship domain showed a minimum score of 14.86 among our study participants. Participants with higher socioeconomic status had shown better scores across all the domains of QOL (p < 0,005). Conclusion: The QOL domain scores are high among males, unmarried, had employment status and had income less than or equal to Rp2.100.000, the distance from the respondent's house to the Health Center was mostly less than or equal to 10 km, did not have a family history of HIV/AIDS, did not have a history of other diseases and therapy treatments other than ARV and mostly experienced side effects.