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All Journal Acta Biochimica Indonesiana Ophthalmologica Indonesiana
Siregar, Astrid Mariam Khairani
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Treatment Strategies of an Iris Implantation Cyst: A Case Report Zarwan, Jessica; Maulidinia, Ayang Rashelda; Siregar, Astrid Mariam Khairani; Widyawati, Syska; Martha, Faraby; Rhendy, Rio
Majalah Oftalmologi Indonesia Vol 51 No 1 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i1.101726

Abstract

Introduction: Iris cyst can be divided into primary and secondary, both originating from epithelial cells. Although rare, the entity has a high recurrence rate. This clinical case report highlights the treatment strategies to treat and prevent the recurrency of iris cyst. Case Report: We report a rare presentation of a secondary iris cyst in a 20-year-old male with a history of cataract surgery 17 years prior. The patient underwent fine-needle aspiration and intracystic alcohol injection. However, the iris cyst recurred eight months after the procedure. Afterward, the invasive strategy of iris cyst excision was conducted. Eight months after the secondary iris cyst surgery, the patient showed no signs of recurrence. Discussion: Iris cyst is known to have a high recurrence rate, however, a minimally invasive treatment is still preferred, supported by previous studies showing no recurrence in treatment with fine-needle aspiration and intracystic alcohol injection. In our case, the iris cyst relapsed eight months after this procedure, warranting for surgical excision. Eight months after the excision, the patient showed no signs of recurrence. Conclusion: Although the recurrency of iris cyst is high, the authors suggest starting with non-invasive treatment with follow-up ensuring no recurrence before opting for a more invasive treatment.
 AN ATYPICAL CASE OF BILATERAL CORNEAL OPACITY: WHAT ARE THE POSSIBLE DIAGNOSIS? Zarwan, Jessica; Siregar, Astrid Mariam Khairani; Pintary, Marsha Rayfa; Widyawati, Syska; Martha, Faraby; Rhendy, Rio
Majalah Oftalmologi Indonesia Vol 50 No 1 (2024): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/c1s1j485

Abstract

Introduction: Corneal opacity can be divided into inflammatory and noninflammatory entities. The clinical presentation and characteristics of a corneal opacity can often help reach a diagnosis. However, atypical cases are more challenging to diagnose. This report aims to explore an atypical case of corneal opacity and the diagnostic approach through its clinical presentation. Case Report: A thirty-seven-year-old female patient had a chief complaint of gradual blurry vision in both eyes and slowly growing whitish lesions one year prior. The patient recalled a history of bilateral eye redness two years ago. The anterior segment examination and AS-OCT revealed bilateral, smooth, oedematous pearly-white elevated opacity with well-demarcated margins at the center of the cornea, with epithelial depth. The diagnosis of corneal keloid was favored, with GDLD and SND as the differential diagnosis. In local anesthesia, the patient underwent superficial keratectomy and amniotic membrane transplantation of the right eye. On one month follow-up, the patient felt an improvement in her subjective complaints with a normal appearance of the cornea. Discussion: The atypical characteristics found in our case didn’t fit a single mold, as it shared features of post- injury hypertrophic scar, degenerative, and dystrophy. We diagnosed the patient with corneal keloid caused by suspicion of subclinical infection. Although GDLD and SND were still possible, the working diagnosis was enough to warrant a therapeutic surgical removal. Conclusion: Atypical presentations make diagnosis more challenging. However, despite improvements in diagnostic modalities, signs, and symptoms remain very helpful in reaching a working diagnosis.
Comparing the effect of Centella asiatica L. and Acalypha indica L. treatment to carbonyl and glutathione level in the brains of old rats Mudjihartini, Ninik; Paramita, Reni; Siregar, Astrid Mariam Khairani; Filzadiyanti, Estiana; Sarsanti, Pungguri Ayu Nega; Purwaningsih, Erni
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.79

Abstract

Background: Free radicals in excessive concentrations damages cells and accelerate the aging process. Antioxidants found in Centella asiatica (CA) and Acalypha indica (AI) have the potential to prevent oxidative cellular damage. Objective: This study aimed to determine the effect of CA and AI on carbonyl and glutathione levels in the brain of older rats. Methods: 18-month age rats were treated using either AI, CA, or vitamin E. In addition, 18-month age and 2-month age untreated rats were used as a negative control. The brain carbonyl and glutathione levels were measured by Agustyanak and the Elmann method, respectively. Results: Treatment with CA significantly decreased brain carbonyl levels (2.87 nmol/mL) than the control rats (4.54 nmol/mL). Furthermore, treating AI did not reduce the brain carbonyl and GSH levels in aged brain rats. Conclusion: Centella asiatica can reduce the protein destruction that occurs with increasing age.
Co-Authors Filzadiyanti, Estiana Martha, Faraby Maulidinia, Ayang Rashelda Ninik Mudjihartini Pintary, Marsha Rayfa Purwaningsih, Erni Reni Paramita Rhendy, Rio Sarsanti, Pungguri Ayu Nega Widyawati, Syska Zarwan, Jessica