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All Journal Informasi dan Promosi Kesehatan Journal of Rural Community Nursing Practice Journal Healthcare Education Journal of Rural Community Nursing Practice Agribiohealth (Journal of Agriculture, Biology & Health Sciences)
Muhlida, Vinilia Ihramatul
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Efficacy of Bay Leaf (Syzygium polyanthum) Decoction in Managing Type 2 Diabetes Mellitus Patients: A Randomized Controlled Trial Kurniawati, Erna Yovi; Muhlida, Vinilia Ihramatul; Dewi, Mariza Mustika; Margiyati
Journal of Rural Community Nursing Practice Vol. 3 No. 1 (2025): March
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jrcnp.v3i1.462

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycaemia, leading to complications such as cardiovascular disease and kidney failure. The increasing prevalence of T2DM necessitates effective management strategies, including complementary therapies like bay leaf (Syzygium polyanthum), which has demonstrated potential for glycaemic control. Purpose: This study aimed to evaluate the effectiveness of bay leaf decoction in improving glycaemic control among T2DM patients in Malangan Village. Methods: A randomized controlled trial (RCT) involved 60 adults aged 30-65 years with fasting blood sugar (FBS) levels between 126-200 mg/dL, selected through purposive sampling. Participants were randomly assigned to an intervention group receiving a bay leaf decoction (10 grams in 250 mL water, twice daily for 12 weeks) or a control group receiving a placebo decoction. Primary outcomes included changes in FBS, while secondary outcomes assessed postprandial blood sugar (PBS) and HbA1c. Compliance and adverse events were monitored, and data were analysed using paired and independent t-tests (p < 0.05). Results: The intervention group showed significant reductions in FBS, PBS, and HbA1c levels compared to the control group (p < 0.05). Older age, female gender, and higher education correlated with improved glycaemic control, while obesity and hypertension were associated with poorer outcomes. No severe adverse events were reported. Conclusion: Bay leaf decoction significantly improves glycaemic control through mechanisms such as enhanced insulin sensitivity, α-glucosidase inhibition, and antioxidant properties. This natural, cost-effective approach is promising as a complementary therapy for T2DM. Future research should explore long-term effects, optimal dosage, and integration with lifestyle interventions to maximize benefits.
Efficacy of Bay Leaf (Syzygium polyanthum) Decoction in Managing Type 2 Diabetes Mellitus Patients: A Randomized Controlled Trial Kurniawati, Erna Yovi; Muhlida, Vinilia Ihramatul; Dewi, Mariza Mustika; Margiyati
Journal of Rural Community Nursing Practice Vol. 3 No. 1 (2025): March
Publisher : Al-Hijrah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58545/jrcnp.v3i1.462

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycaemia, leading to complications such as cardiovascular disease and kidney failure. The increasing prevalence of T2DM necessitates effective management strategies, including complementary therapies like bay leaf (Syzygium polyanthum), which has demonstrated potential for glycaemic control. Purpose: This study aimed to evaluate the effectiveness of bay leaf decoction in improving glycaemic control among T2DM patients in Malangan Village. Methods: A randomized controlled trial (RCT) involved 60 adults aged 30-65 years with fasting blood sugar (FBS) levels between 126-200 mg/dL, selected through purposive sampling. Participants were randomly assigned to an intervention group receiving a bay leaf decoction (10 grams in 250 mL water, twice daily for 12 weeks) or a control group receiving a placebo decoction. Primary outcomes included changes in FBS, while secondary outcomes assessed postprandial blood sugar (PBS) and HbA1c. Compliance and adverse events were monitored, and data were analysed using paired and independent t-tests (p < 0.05). Results: The intervention group showed significant reductions in FBS, PBS, and HbA1c levels compared to the control group (p < 0.05). Older age, female gender, and higher education correlated with improved glycaemic control, while obesity and hypertension were associated with poorer outcomes. No severe adverse events were reported. Conclusion: Bay leaf decoction significantly improves glycaemic control through mechanisms such as enhanced insulin sensitivity, α-glucosidase inhibition, and antioxidant properties. This natural, cost-effective approach is promising as a complementary therapy for T2DM. Future research should explore long-term effects, optimal dosage, and integration with lifestyle interventions to maximize benefits.
EFFECT OF CLITORIA TERNATEA ON FOLLICULOGENESIS POLYCISTIC OVARY SYNDROME: IN SILICO STUDY ON LUTEINIZINNG HORMONE RECEPTOR Kurniawati, Erna Yovi; Muhlida, Vinilia Ihramatul
Journal Healthcare Education Vol. 3 No. 2 (2025): Volume 3 No. 2 2025
Publisher : Yayasan Healing and Healthcare Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jhce.v3i2.90

Abstract

Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder involving dysregulation of luteinizing hormone (LH) and its receptor, leading to menstrual irregularities and anovulation. This study evaluates the potential of Clitoria ternatea, a traditional medicinal plant, in modulating LH receptor activity through in silico analysis. Methods: Active compounds from Clitoria ternatea, including flavonols (kaempferol, isorhamnetin), flavones (baicalein, luteolin, apigenin), phenolic acids (chlorogenic, protocatechuic, gallic), and epicathechin, were identified via PubChem. Lipinski’s rule and LD50 classifications were used to assess drug-like properties and toxicity. Bioactivity was predicted using PASS Online, SwissTarget Prediction, PharmMapper, and SuperPred. The LH receptor's 3D structure was modeled using Swiss Model and validated with Procheck and Errat Check. Molecular docking studies using PyRx assessed binding affinities between the compounds, spironolactone, flutamide, and the LH receptor. Results: Docking results revealed strong binding affinities of Clitoria ternatea compounds with the LH receptor, particularly phenolic acids and flavonoids, showing comparable or better interactions than spironolactone and flutamide. These interactions suggest a potential role in restoring hormonal balance and ovulatory function. The study highlights the therapeutic potential of Clitoria ternatea for PCOS management. Its compounds demonstrate significant LH receptor interactions, offering a promising basis for further research. Conclusion: Clitoria ternatea shows promise as a natural therapeutic candidate for PCOS. Future in vitro, in vivo, and clinical trials are needed to validate these findings
Effect of Clitoria ternatea on Androgen Receptor: Molecular Docking Study Kurniawati, Erna Yovi; Muhlida, Vinilia Ihramatul
Infomasi dan Promosi Kesehatan Vol 4 No 2 (2025): Informasi dan Promosi Kesehatan
Publisher : Sahabat Publikasi Kuu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58439/ipk.v4i2.374

Abstract

Introduction: Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that affects many women worldwide, characterized in part by elevated androgen levels that can lead to various health complications. Traditional medicinal plants, such as Clitoria ternatea, have been explored as potential therapeutic agents for managing PCOS. Methods: This study employed an in silico approach to evaluate the interaction between active compounds in Clitoria ternatea and the androgen receptor. Molecular docking, molecular dynamics simulations, and binding affinity analyses were conducted to assess the potential of these compounds in modulating androgen receptor activity Results: The computational analysis revealed that several active compounds in Clitoria ternatea exhibited favorable binding interactions with the androgen receptor, indicating a potential to modulate its activity. These compounds demonstrated stable interactions and promising binding energies in the molecular simulations. Conclusion These findings suggest that Clitoria ternatea may play a role in managing PCOS through modulation of androgen receptor activity. However, further in vitro and in vivo studies are required to validate these computational results and explore their therapeutic potential in clinical settings.
Pengaruh Rebusan Daun Centella asiatica terhadap Kadar HOMA IR Wanita dengan Sindrom Ovarium Polikistik Muhlida, Vinilia Ihramatul; Kurniawati, Erna Yovi
Agribiohealth (Journal of Agriculture, Biology & Health Sciences) Vol. 1 No. 2 (2025): Agribiohealth (Journal of Agriculture, Biology & Health Sciences)
Publisher : Medico Insight Innovation Initiative

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65318/agribiohealth.v1i2.17

Abstract

Sindrom Ovarium Polikistik (PCOS) merupakan gangguan endokrin yang sering dikaitkan dengan resistensi insulin dan inflamasi kronis derajat rendah. Kondisi ini berkontribusi terhadap gangguan metabolik dan reproduksi, meningkatkan risiko diabetes tipe 2, serta disfungsi ovulasi. Salah satu terapi potensial adalah penggunaan bahan alami seperti Centella asiatica, yang diketahui memiliki sifat antiinflamasi dan meningkatkan sensitivitas insulin. Penelitian ini bertujuan untuk menilai efek rebusan Centella asiatica terhadap kadar glukosa darah puasa, kadar insulin puasa, dan HOMA-IR pada wanita dengan PCOS. Penelitian ini merupakan Randomized Controlled Trial (RCT) double-blind, placebo-controlled dengan 26 peserta yang dibagi dalam kelompok intervensi (Centella asiatica 500 ml/hari) dan kontrol (placebo) selama 8 minggu. Instrumen yang digunakan mencakup pemeriksaan kadar glukosa darah puasa menggunakan metode hexokinase, kadar insulin puasa menggunakan enzyme-linked immunosorbent assay (ELISA), serta perhitungan HOMA-IR dengan rumus standar. Data diuji normalitasnya dengan Shapiro-Wilk test dan dianalisis menggunakan paired t-test serta independent t-test. Kelompok intervensi menunjukkan penurunan signifikan kadar glukosa (p = 0,045), insulin (p = 0,032), dan HOMA-IR (p = 0,021) dibandingkan dengan kelompok kontrol. Konsumsi rebusan Centella asiatica efektif menurunkan resistensi insulin pada PCOS, menunjukkan potensinya sebagai terapi komplementer. Studi lebih lanjut diperlukan untuk mengevaluasi efektivitas jangka panjang dan mekanisme kerjanya secara lebih mendalam.
Education on the Utilization of Herbal Phytotherapy Moringa Aloifera as an Alternative Nutritional Intervention for the Prevention of Stunting in Toddlers Muhlida, Vinilia Ihramatul; Kurniawati, Erna Yovi
Agribiohealth (Journal of Agriculture, Biology & Health Sciences) Vol. 1 No. 4 (2025): Agribiohealth (Journal of Agriculture, Biology & Health Sciences)
Publisher : Medico Insight Innovation Initiative

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65318/agribiohealth.v1i4.23

Abstract

Stunting remains a major chronic nutritional issue in Indonesia, including the Yogyakarta region. One preventive approach is nutrition education during the pre-marital period. Moringa oleifera is recognized as a highly nutritious local plant with potential in preventing stunting. This study employed a double-blind randomized controlled trial design involving 46 prospective brides in Yogyakarta. The intervention group received herbal phytotherapy education through an online pocketbook focused on the benefits of Moringa oleifera, while the control group received standard education from the Religious Affairs Office (KUA). Knowledge levels were assessed before and after the intervention using a structured questionnaire. There was a significant increase in knowledge scores in the intervention group (pre-test: 48.55 ± 0.93; post-test: 75.09 ± 0.95; p = 0.016), while the increase in the control group was not statistically significant. An independent t-test showed a significant difference in post-test scores between the two groups (p = 0.003). Online pocketbook-based education on Moringa oleifera herbal phytotherapy effectively increased knowledge of stunting prevention among prospective brides. This approach has strong potential as a community intervention strategy that is locally sourced, low-cost, accessible, and sustainable.
Co-Authors Dewi, Mariza Mustika Kurniawati, Erna Yovi Margiyati