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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Medical Chemistry and Bioinformatics
Harimurti, Putri Saskia
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Chemistry Computer Science & IT Public Health

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ANALISIS KESIAPAN PENERAPAN REKAM MEDIS ELEKTRONIK (RME) MELALUI PENDEKATAN DOQ-IT DI PUSKESMAS PADARINCANG Cahyaningtias, Ratu Nadia; Harimurti, Putri Saskia; Raihana, Dalia Sharliz; Akram, Muh
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.43373

Abstract

Penelitian ini bertujuan untuk menganalisis kesiapan penerapan rekam medis elektronik melalui pendekatan DOQ-IT dengan menganalisis pengaruh Kepemimpinan terhadap Manajemen Informasi, Staf Klinis & Administrasi, dan Infrastruktur Teknologi di sektor kesehatan. Latar belakang penelitian ini didorong oleh pentingnya faktor kepemimpinan dalam meningkatkan kinerja organisasi kesehatan yang berhubungan dengan kualitas pengelolaan informasi, pengelolaan staf, dan pengembangan infrastruktur teknologi. Metode yang digunakan adalah Structural Equation Modeling (SEM) dengan total sampling pada 50 responden yang bekerja di berbagai profesi kesehatan di Puskesmas Padarincang. Data dikumpulkan menggunakan kuesioner DOQ-IT yang berisi pertanyaan pilihan ganda. Hasil analisis menunjukkan bahwa Kepemimpinan memiliki pengaruh signifikan terhadap Manajemen Informasi, Staf Klinis & Administrasi, dan Infrastruktur Teknologi dengan nilai path coefficient antara 0,45 hingga 0,60. Selain itu, hasil R² menunjukkan bahwa Infrastruktur Teknologi dijelaskan paling tinggi oleh faktor-faktor yang ada, dengan nilai R² mencapai 61%. Kesimpulan mengemukakan bahwa Kepemimpinan memiliki peran krusial dalam meningkatkan pengelolaan informasi, kinerja staf, serta pengembangan infrastruktur teknologi, yang pada gilirannya dapat meningkatkan kinerja organisasi kesehatan secara keseluruhan.
Virtual Screening on Indonesian Herbal Compounds as SARS-CoV-2 Spike (S2) Glycoprotein Inhibitors: Pharmacophore Modelling & Molecular Docking Approaches Sugito, Syailendra Karuna; Cristina, Artha Uli; Harimurti, Putri Saskia; Cendani, Gabriella Regita; Insani, Fauzi Azhar; Erlina, Linda; Paramita, Rafika Indah; Fadilah, Fadilah
Indonesian Journal of Medical Chemistry and Bioinformatics Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: There are still no specific treatments for coronavirus disease (COVID-19) until present days. Several studies have been conducted to determine whether herbal medicine can be an option to be used as a definitive medicine for COVID-19. S2 subunit of spike protein which is responsible for SARS-CoV-2 entry to the host cell, is a potential drug target to inhibit the viral infection. In this study, we aimed to find some compounds from the HerbalDB database that have potential as SARS-CoV-2 spike (S2) glycoprotein inhibitor. Methods: The 6LXT protein was used as the target protein. The procedure in this study consisted of these following steps: protein and ligand preparation, pharmacophore modelling and compound screening, molecular docking, ADME, and toxicity analysis. The docking of hit compounds to the target protein were compared to arbidol and quercetin as positive controls. Results: Four hit compounds were screened from HerbalDB compounds. Two of them, octopamine and L-noradrenaline, showed lower binding energies (respectively, -5.19 and -4.98 kcal/mol) than positive controls whereas the other two compounds, mimosine and L-theanine, showed higher binding energies (respectively, -3.99 and -3.62 kcal/mol) compared to positive controls. Mimosine, L-noradrenaline, octopamine, and L-theanine had toxicity classes of IV, II, IV, and IV, respectively. Conclusion: Octopamine shows the best potential as SARS-CoV-2 spike (S2) glycoprotein inhibitor. However, this compound also poses several toxicity risks and therefore, needs a more elaborate considera-tion upon using. There are still no specific treatments for coronavirus disease (COVID-19) until present days. Several studies have been conducted to determine whether herbal medicine can be an option to be used as a definitive medicine for COVID-19. S2 subunit of spike protein which is responsible for SARS-CoV-2 entry to the host cell, is a potential drug target to inhibit the viral infection. In this study, we aimed to find some compounds from the HerbalDB database that have potential as SARS-CoV-2 spike (S2) glycoprotein inhibitor.
Co-Authors Akram, Muh Cahyaningtias, Ratu Nadia Cendani, Gabriella Regita Cristina, Artha Uli Erlina, Linda Fadilah Fadilah, Fadilah Insani, Fauzi Azhar Paramita, Rafika Indah Raihana, Dalia Sharliz Sugito, Syailendra Karuna