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Skrining fitokimia dan aktivitas antioksidan ekstrak etanol daging buah pala (Myristica fragrans) kawasan Aceh Selatan, Indonesia. Azhari , Saiful; Kurniaty , Rina; Yusuf, Muhammad; Zulyani , Riza; Mahmudi , Mahmudi; Rani, Wahyu Mustika; Farida , Mutia
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.421

Abstract

The nutmeg fruit (Myristica fragrans) shows the presence of secondary metabolite compounds and has antioxidant activity. The nutmeg examined in this study is the flesh of the fruit and dried for seven days to obtain simplisia. The extraction process is by maceration method using 96% ethanol solvent. Based on the results of phytochemical screening of ethanol extracts of nutmeg flesh showed the presence of secondary metabolite compounds, which are groups of alkaloids, steroids, saponins and flavonoids. The results of antioxidant activity of ethanol extract of nutmeg flesh have an IC50 value of 22.88 ppm. In this study using vitamin C as a positive control for comparison with the IC50 value obtained is 3.82 ppm. The more secondary metabolite compounds in an extract, the higher the antioxidant activity.
Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Ciplukan (Physalis angulata L) Dikawasan Manifestasi Geothermal Seulawah Agam Farida , Mutia; Azhari , Saiful; Darsa , Dimas Dwi; Mahmudi , Mahmudi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.826

Abstract

Ciplukan leaves (Physalis angulata L.) from the Seulawah Agam geothermal manifestation area exhibit strong potential as a natural antioxidant source. This study investigates the phytochemical content and antioxidant activity of ethanol extract from ciplukan leaves using UV-Vis spectrophotometry. The research begins with sample collection and plant determination, followed by phytochemical screening and antioxidant activity testing using the DPPH method. Phytochemical screening results reveal the presence of alkaloids, flavonoids, tannins, saponins, and steroids. Antioxidant activity testing using the DPPH method yields an IC50 value of 14.99 μg/mL, significantly lower than the positive control, ascorbic acid (19.40 μg/mL), indicating strong antioxidant activity. At the highest tested concentration (50 μg/mL), the extract exhibits an inhibition percentage of 81.84%, while at the lowest concentration (10 μg/mL), it shows an inhibition of 41.41%. These findings confirm that the ethanol extract of ciplukan leaves from the geothermal area possesses high antioxidant content and has great potential for applications in the development of natural-based pharmaceutical and nutraceutical products.