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p-Index From 2020 - 2025
0.444
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All Journal Jurnal Kesehatan Amanah The International Journal of Medical Science and Health Research
Bulkis Natsir
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Hubungan Antara Karakteristik Klinis Pasien TB Paru dengan Gambaran Radiologi CT Scan Thorax Nurfika Utami; Rahmawati, Rahmawati; Bulkis Natsir
Jurnal Kesehatan Amanah Vol. 7 No. 2 (2023): Oktober: Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v7i2.749

Abstract

Tuberculosis infection is one of the most common and dangerous human infections. Tuberculosis infection is a health problem in which one-third of the world's population is infected with Mycobacterium tuberculosis. The diagnosis of TB is still limited to the results of clinical examination, laboratory examination of BTA sputum and conventional thoracic X-rays. Meanwhile, CT scanning has not yet become a standard modality, due to its high cost and unavailability in many primary health care centres. However, CT scans are considered to have advantages in diagnosing minimal lesions, differentiating active and inactive conditions, assessing endobronchial expansion, and better diagnosing pulmonary TB with negative acid-resistant bacteria (BTA) sputum examination results. The method used was a literature review with a Narrative Review design to identify and summarise previously published articles on the relationship between clinical characteristics of pulmonary TB patients and CT scan radiological images. From the 4 articles summarised, it was found that the large number of variations that are not typical of thoracic CT scans of pulmonary TB patients make the diagnosis of pulmonary TB more complicated. It takes precision and good cooperation between radiologists and clinicians to jointly make a correct diagnosis of pulmonary TB.
Type 2 Diabetes Mellitus and The Risk of Tuberculosis Sri Rahmayanti Limatahu; Darariani Iskandar; Bulkis Natsir
The International Journal of Medical Science and Health Research Vol. 13 No. 7 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/pf3ta382

Abstract

Type 2 Diabetes Mellitus (T2DM) is a major comorbidity that increases the risk of tuberculosis (TB) through immune system impairment caused by chronic hyperglycemia, including macrophage dysfunction, reduced T-cell activity, oxidative stress, and cytokine imbalance. This literature review aims to analyze the relationship between T2DM and TB from the perspectives of pathophysiology, clinical impact, and healthcare system challenges. The method used is a descriptive narrative based on 10 scientific articles and case reports published between 2020 and 2025, selected through systematic searching. The results show that T2DM contributes to an increased risk of active TB, prolonged treatment duration, lower treatment success rates, and a higher risk of drug resistance. Behavioral factors such as poor glycemic control, smoking habits, and limited access to healthcare further worsen the condition of patients with this comorbidity. On the other hand, bidirectional TB-DM screening efforts in Indonesia have not been optimal due to limitations in training, infrastructure, and inter-program coordination. In conclusion, T2DM increases susceptibility to TB and worsens its progression, highlighting the need for integrated healthcare services, strict blood glucose control, and systemic policy interventions to reduce the morbidity and mortality associated with this comorbidity.
Co-Authors Darariani Iskandar Nurfika Utami Rahmawati, Rahmawati Sri Rahmayanti Limatahu