Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Irviansyah, Cepy Okta
Unknown Affiliation
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
AKTIVITAS ANTIINFLAMASI DAN ANTIOKSIDAN KOMBINASI EKSTRAK ETANOL BUNGA ROSELA (Hibiscus sabdariffa) DAN DAUN PEGAGAN (Centella asiatica) PADA TIKUS WISTAR JANTAN DENGAN OBESITAS Kaniawati, Marita; Sulaeman, Agus; Susilawati, Elis; Zinan, Daula Zahra; Irviansyah, Cepy Okta
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2323

Abstract

One of the triggers for obesity is high fat and high carbohydrates foods which increase Free Fatty Acid (FFA) and Reactive Oxygen Species (ROS), that trigger oxidative stress and chronic inflammation, which play a role in various degenerative diseases. This study aims to determine the potency and effective dose of ethanol extract of roselle flowers (Hibiscus sabdariffa) and gotu kola leaves (Centella asiatica) combination on oxidative stress (represented by Malondialdehyde or MDA) and its effect on inflammation (represented by Tumor Necrosis Factor-α or TNF-α). This research used in vivo experimental preventive method using 35 mice which were divided into normal group, induction group, comparison group curcumin 1.8 mg/kgBW, test group 1 EDP 200 mg/kgBW, test group 2 EBR 250 mg/kgBW, test group 3 EBRDP 125:200 mg/kgBW and test group 4 EBRDP 250:100 mg/kgBW. MDA levels were measured using UV-Vis spectrophotometry at 532 nm and TNF-α levels were measured using an ELISA kit on the 60th day. The results showed a decrease in blood MDA levels in EDP 200 mg/kgBW, EBR 250 mg/kgBW and EBRDP 250: 100 mg/kgBW and in liver MDA levels in EDP 200 mg/kgBW and EBRDP 250:100 mg/kgBW. The study also showed decreasing TNF-α levels in EDP 200 mg/kg BW, EBR 250 mg/kgBW, and the combination of EBRDP dose 125:200 mg/kgBW. In conclusion, the combination of EBRDP dose 250:100 mg/kgBW is the most effective dose in reducing MDA levels. The combination of EBRDP dose 125:200 mg/kgBW is the most effective dose in suppressing TNF-α levels.
Co-Authors Agus Sulaeman Marita Kaniawati Susilawati, Elis Zinan, Daula Zahra