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All Journal Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE
Putria, Sinta Julia Liona
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Potential of Rosella (Hibiscus sabdariffa L.) for Diabetes Mellitus Model Rats: Histopathological Focus on Pancreatic Organ Putria, Sinta Julia Liona; Rohani, Siti; Suarni, Ertati; Astri, Yesi; Mundijo, Trisnawati
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.236

Abstract

Introduction. Ethanolic extract of rosella flowers (Hibiscus sabdariffa L.) contains secondary metabolite compounds: flavonoids, alkaloids, saponins, and tannins. This study aims to determine whether the ethanol extract of rosella flowers has the potential to regenerate pancreatic β cells in white rats (Rattus norvegicus) with alloxan-induced diabetes mellitus models.  Methods. The type of research used was an in vivo laboratory experimental study with a true experimental design. The experimental animals used as test objects in this study were male rats (Rattus norvegicus L.), weighing 100-110 grams. The test objects were 30 rats, divided into 6 groups randomly, each containing 5 rats, the groups consisted of K (N), K (-), K (+), P (1), P (2), and P (3). The level of histopathological damage to the pancreas was observed with HE staining at 400x magnification, using binocular light microscope type CX23 and BX51. Results. The study showed that the ethanol preparation of rosella flower extract at a dose of 1500 mg/kgBW and 3000 mg/kgBW BB was effective in regenerating pancreatic β cells with a damage value of 0 and at a dose of 750 mg/kgBW with a damage value of 2 did not provide a maximum regeneration effect on pancreatic β cells in male white rats induced by alloxan. Conclusion. The results of this research show that the ethanol extract of rosella flowers has an influence on the regeneration of pancreatic β cells so that it can be used for supportive treatment in the management of diabetes mellitus.
Identification of Chemical Constituents in Ethanolic Extract of Hibiscus sabdariffa L. Calyces (Roselle) by FTIR and GC-MS: Preliminary Phytochemical Screening Rohani, Siti; Martha, Fadhil Rizki; Astri, Yesi; Putria, Sinta Julia Liona
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025 (Issue In Progress)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.360

Abstract

Indonesia is widely recognized for its rich biodiversity, which has long served as a valuable resource for traditional herbal medicine. In recent years, interest in plant-based therapies has grown significantly. One such plant, Hibiscus sabdariffa L., commonly known as Rosella, is valued for its therapeutic properties. These benefits arise from the combined effects of its bioactive compounds, allowing it to address a range of health issues. Research has shown that Rosella contains notable levels of flavonoids, saponins, tannins, and alkaloids—all of which contribute to its antibacterial activity. Techniques such as Fourier-transform infrared (FTIR) spectroscopy and gas chromatography–mass spectrometry (GC-MS) are employed to identify these chemical constituents. FTIR analysis has detected functional groups like amines, fatty acids, aldehydes, carboxylic acids, and aromatic rings. Additionally, GC-MS results have indicated the presence of major compounds belonging to the methyl ester group. Noteworthy identified substances include Hexadecanoic Acid Methyl Ester, Hexadecanoic Acid Ethyl Ester, and Benzenepropanoic Acid, 3,5-Bis(1,1-Dimethylethyl)-4-Hydroxy-, Methyl Ester. A review of existing prior research suggests that these compound groups exhibit significant pharmacological potential, including the usage for antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory effects.
Co-Authors Martha, Fadhil Rizki Mundijo, Trisnawati Siti Rohani Suarni, Ertati Yesi Astri