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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati KLOROFIL: Jurnal Ilmu Biologi dan Terapan JNANALOKA KLOROFIL: Jurnal Ilmu Biologi dan Terapan Oryza : Jurnal Pendidikan Biologi Herbal Medicine Journal Jurnal Riset dan Pengabdian Interdisipliner
Fasha, Gusti Nur Aida
Program Studi Biologi FMIPA, Universitas Lambung Mangkurat, Banjarbaru
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Social Sciences Transportation Other

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Analisis GC-MS Digesta Serta Konsumsi Pakan dan Berat Badan Tikus (Rattus norvegicus Berkenhout) Setelah Pemberian Fermentasi Tigarun (Crataeva nurvala Buch.-Ham) Fasha, Gusti Nur Aida; Weridyaningrum, Ratu
ORYZA ( JURNAL PENDIDIKAN BIOLOGI ) Vol 14 No 1 (2025): ORYZA: Jurnal Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi STKIP Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33627/oz.v14i1.3145

Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh pemberian jus fermentasi tigarun (Crataeva nurvala Buch.-Ham) terhadap konsumsi pakan, berat badan, dan kandungan senyawa volatile dalam saluran pencernaan tikus (Rattus norvegicus Berkenhout). Sebanyak 24 ekor tikus Wistar berusia 12 minggu dibagi menjadi empat kelompok perlakuan: kontrol (K), tikus dengan intervensi tinggi kalori (TK), tikus yang diberikan jus fermentasi tigarun (KJT), dan tikus dengan intervensi tinggi kalori serta jus fermentasi tigarun (TKJT). Penelitian ini menggunakan tikus Wistar jantan yang diberi intervensi nutrien dengan jus fermentasi tigarun, diukur konsumsi pakan dan berat badannya selama 28 hari, dianalisis komposisi senyawa volatile sekumnya dengan GC-MS, dan diuji secara statistik menggunakan One-Way ANOVA serta Uji Duncan untuk menentukan pengaruh fermentasi tigarun. Hasil menunjukkan bahwa konsumsi pakan lebih tinggi pada kelompok K (101,29±30,72 gram) dan KJT (91,25±40,46 gram) dibandingkan TK (61,89±26,93 gram) dan TKJT (55,32±29,61 gram). Namun, kelompok TKJT memiliki berat badan akhir tertinggi (256,67±2,05 gram). Analisis GC-MS menunjukkan kadar asam lemak dodekanoat yang tinggi pada kelompok TKJT dengan persentase relative sebesar 24,22%, yang diduga berperan dalam regulasi mikrobiota saluran cerna. Temuan ini menunjukkan bahwa jus fermentasi tigarun berpotensi meningkatkan efisiensi penyerapan nutrien dan mempengaruhi metabolisme saluran pencernaan.
Prediksi In Silico Senyawa Berpotensi Anti-Kolesterol pada Kopi Robusta (Coffea canephora Pierre ex A. Froehner) Aida Fasha, Gusti Nur; Pangestika, Intan Widya
JNANALOKA Vol. 06 No. 01 Maret Tahun 2025
Publisher : Lentera Dua Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36802/jnanaloka.2025.v6-no1-1-11

Abstract

Kopi robusta (Coffea canephora Pierre ex A. Froehner) merupakan salah satu komoditas penting di Indonesia yang memiliki potensi besar dalam bidang kesehatan, termasuk sebagai agen anti-kolesterol. Penelitian ini bertujuan untuk memprediksi senyawa dalam kopi robusta yang berpotensi sebagai anti-kolesterol menggunakan pendekatan in silico. Senyawa yang terkandung dalam kopi robusta diidentifikasi melalui basis data KNApSAcK, kemudian dianalisis menggunakan PASS Online untuk memprediksi aktivitasnya sebagai agen anti-kolesterol. Selanjutnya, prediksi target biologis dilakukan menggunakan SwissTargetPrediction, dan kecocokan farmakokinetik senyawa dianalisis berdasarkan Lipinski’s Rule melalui SwissADME. Hasil analisis menunjukkan bahwa beberapa senyawa memiliki potensi aktivitas tinggi sebagai agen anti-kolesterol, di antaranya delta7-Avenasterol, delta7-Stigmastenol, (3beta,5alpha)-Stigmastan-3-ol, (-)-beta-Sitosterol, dan Clerosterol, yang diprediksi berinteraksi dengan enzim sitokrom P450 dan reseptor nuklear yang berperan dalam regulasi kolesterol. Namun, senyawa ini memiliki nilai lipofilisitas tinggi, yang dapat mempengaruhi penyerapannya dalam tubuh. Sebaliknya, senyawa 2,3-Butanedione, Toluene, 2,3-Dimethylpyrazine, Phenol, dan Pyridine memenuhi semua kriteria Lipinski’s Rule, menunjukkan potensi lebih besar sebagai kandidat obat yang dapat dikembangkan lebih lanjut. Penelitian lanjutan diperlukan dalam bentuk uji in vitro dan in vivo guna mengonfirmasi efektivitas serta mekanisme kerja senyawa-senyawa ini dalam menurunkan kadar kolesterol. Selain itu, optimasi formulasi farmasi dan studi toksikologi perlu dilakukan untuk menjamin keamanan dan efektivitasnya sebagai agen terapi anti-kolesterol. Penelitian ini diharapkan dapat menjadi dasar dalam pengembangan obat berbasis senyawa alami dari kopi robusta, mendukung pemanfaatan komoditas lokal Indonesia dalam bidang kesehatan.
Isolation and Screening of Cellulolytic Soil Bacteria from Dramaga Forest in Bogor Weridyaningrum, Ratu; Imaningsih, Witiyasti; Fasha, Gusti Nur Aida
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 2 (2025): June 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i2.11262

Abstract

Cellulolytic bacteria can produce cellulase enzymes, which allow them to degrade cellulose into simpler chemicals while using it as a growth substrate. These bacteria have drawn a lot of interest due to their unique properties and potential uses, such as in agriculture and the food industry. Soil is one of the habitats of cellulolytic bacteria. This study aims to determine the potential and screening of cellulolytic bacterial isolates. Cellulolytic bacteria were isolated from soil samples and cultured using selective Carboxyl Methyl Cellulose (CMC) media. Five purified isolates were collected, and their cellulase enzyme activity was qualitatively assessed using the Congo red test. Isolated bacteria code Area Jalan Setapak (AJS1) produced a higher clear zone index and will be used for further testing. Quantitative analysis of isolate AJS1 revealed its highest enzyme activity after ten minutes of incubation, with 0.0049 U/mL unit activity and 0.018 U/mg specific activity. Based on morphological and biochemical characteristics, isolated AJS1 was identified as Corynebacterium spp.
Uji Potensi Probiotik Isolat Lactobacillus plantarum JBSxH.6.4 Asal Fermentasi Tigarun (Crateva nurvala Buch.-Ham.) Secara In Vitro Fasha, Gusti Nur Aida; Nur, Hasrul Satria; Rahmi, Nazarni
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.145

Abstract

Lactobacillus plantarum JBSxH.6.4 isolate was isolated from fermented food of Tigarun (Crateva nurvala Buch.-Ham.), a traditional fermented food from Kalimantan. This study aimed to evaluate its probiotic potential through a series of in vitro tests, including hemolysis analysis, tolerance to acidic pH and bile salt, inhibitory activity against pathogenic bacteria, and interactions with nonpathogenic bacteria. The results showed that Lac. plantarum JBSxH.6.4 exhibited γ-hemolysis, confirming its non-pathogenicity. The isolate survived at pH levels of 2.0, 3.0, and 4.0, demonstrating its acid tolerance. It also exhibited resistance to 0.3% (w/v) bile salt, indicating its ability to survive in the digestive tract. Furthermore, Lac. plantarum JBSxH.6.4 inhibited the growth of Escherichia coli ATCC25922 at 8,08 ± 0,34 mm and Staphylococcus aureus ATCC25923 at 8,95 ± 0,15 mm, suggesting its antimicrobial properties. Additionally, interaction tests indicated that it did not inhibit Lactobacillus acidophilus FNCC0051, supporting its compatibility with beneficial gut microbiota. These findings suggest that Lac. plantarum JBSxH.6.4 meets key probiotic criteria and has potential applications in functional foods and health industries. Further studies, including in vivo evaluations, are recommended to confirm its efficacy and safety for human.
Daya Hambat Bakteri Lactobacillus plantarum JBS4 Asal Fermentasi Tigarun Terhadap Bakteri Patogen Fasha, Gusti Nur Aida; Rahmi, Nazarni; Nur, Hasrul Satria
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Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jrpi.v2i1.30560

Abstract

Lactobacillus plantarum JBS4 is a lactic acid bacterium isolated from the fermentation of tigarun (Crataeva nurvala Buch.-Ham) with potential antimicrobial activity. This study aimed to evaluate the inhibitory effect of Lac. plantarum JBS4 against pathogenic bacteria Escherichia coli ATCC25922 and Staphylococcus aureus ATCC25923 in vitro. The inhibition test was conducted using the well diffusion method on NA and MRS agar media. The results showed that Lac. plantarum JBS4 effectively inhibited the growth of E. coli and S. aureus, with inhibition zone diameters of 9.10 ± 0.08 mm and 9.32 ± 0.29 mm, respectively. Furthermore, this isolate did not exhibit inhibitory effects against Lactobacillus acidophilus FNCC0051, a nonpathogenic bacterium. These findings suggest that Lac. plantarum JBS4 has the potential to act as a selective antimicrobial agent against pathogenic bacteria without affecting beneficial microorganisms.
Isolation and Screening of Cellulolytic Soil Bacteria from Dramaga Forest in Bogor Weridyaningrum, Ratu; Imaningsih, Witiyasti; Fasha, Gusti Nur Aida
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 2 (2025): June 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i2.11262

Abstract

Cellulolytic bacteria can produce cellulase enzymes, which allow them to degrade cellulose into simpler chemicals while using it as a growth substrate. These bacteria have drawn a lot of interest due to their unique properties and potential uses, such as in agriculture and the food industry. Soil is one of the habitats of cellulolytic bacteria. This study aims to determine the potential and screening of cellulolytic bacterial isolates. Cellulolytic bacteria were isolated from soil samples and cultured using selective Carboxyl Methyl Cellulose (CMC) media. Five purified isolates were collected, and their cellulase enzyme activity was qualitatively assessed using the Congo red test. Isolated bacteria code Area Jalan Setapak (AJS1) produced a higher clear zone index and will be used for further testing. Quantitative analysis of isolate AJS1 revealed its highest enzyme activity after ten minutes of incubation, with 0.0049 U/mL unit activity and 0.018 U/mg specific activity. Based on morphological and biochemical characteristics, isolated AJS1 was identified as Corynebacterium spp.
Studi In Silico dan Prediksi Efisiensi Administrasi In Vivo Senyawa Berpotensi Obat pada Tumbuhan Cempedak (Artocarpus integer) Aida Fasha, Gusti Nur
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 9, No 1 (2025): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v9i1.26526

Abstract

Artocarpus integer (cempedak) is a tropical plant widely used in South Kalimantan, known for its rich bioactive compounds, which make it a promising source for drug discovery through in silico approaches. This study aims to identify and predict the potential of bioactive compounds from A. integer as drug candidates through an in silico approach. The data were obtained from the KNApSAcK database and analyzed using the SwissADME, SwissTargetPrediction, PASS Online, and GUSAR platforms to evaluate pharmacokinetic suitability, biological targets, pharmacological activities, and predictive toxicity. Four compounds were identified, namely Integrin, Oxyisocyclointegrin, Cyclointegrin, and Artoindonesianin F. The analysis revealed that the first three compounds comply with Lipinski's Rule of Five, indicating favorable metabolic properties. In contrast, Artoindonesianin F does not meet these criteria due to its high lipophilicity. Molecular target prediction suggested that the active compounds interact with enzyme groups such as proteases, kinases, and phosphodiesterases, which play crucial roles in the therapeutic mechanisms of various degenerative diseases and cancers. Based on PASS Online analysis, Oxyisocyclointegrin and Cyclointegrin exhibited high probabilities of biological activity (Pa > 0.9), including cell membrane stabilization, enhancement of TP53 gene expression, and inhibition of cytochrome P450 enzymes. Toxicity analysis using GUSAR indicated that both compounds possess low toxicity levels, with oral LD₅₀ values of 1437 mg/kg and 1164 mg/kg, respectively. Therefore, Oxyisocyclointegrin and Cyclointegrin show promising potential as natural bioactive compound candidates for further development in natural product-based pharmacotherapy research.
Studi In Silico dan Prediksi Efisiensi Administrasi In Vivo Senyawa Berpotensi Obat pada Tumbuhan Cempedak (Artocarpus integer) Aida Fasha, Gusti Nur
KLOROFIL: Jurnal Ilmu Biologi dan Terapan Vol 9, No 1 (2025): KLOROFIL: JURNAL ILMU BIOLOGI DAN TERAPAN
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/kfl:jibt.v9i1.26526

Abstract

Artocarpus integer (cempedak) is a tropical plant widely used in South Kalimantan, known for its rich bioactive compounds, which make it a promising source for drug discovery through in silico approaches. This study aims to identify and predict the potential of bioactive compounds from A. integer as drug candidates through an in silico approach. The data were obtained from the KNApSAcK database and analyzed using the SwissADME, SwissTargetPrediction, PASS Online, and GUSAR platforms to evaluate pharmacokinetic suitability, biological targets, pharmacological activities, and predictive toxicity. Four compounds were identified, namely Integrin, Oxyisocyclointegrin, Cyclointegrin, and Artoindonesianin F. The analysis revealed that the first three compounds comply with Lipinski's Rule of Five, indicating favorable metabolic properties. In contrast, Artoindonesianin F does not meet these criteria due to its high lipophilicity. Molecular target prediction suggested that the active compounds interact with enzyme groups such as proteases, kinases, and phosphodiesterases, which play crucial roles in the therapeutic mechanisms of various degenerative diseases and cancers. Based on PASS Online analysis, Oxyisocyclointegrin and Cyclointegrin exhibited high probabilities of biological activity (Pa > 0.9), including cell membrane stabilization, enhancement of TP53 gene expression, and inhibition of cytochrome P450 enzymes. Toxicity analysis using GUSAR indicated that both compounds possess low toxicity levels, with oral LD₅₀ values of 1437 mg/kg and 1164 mg/kg, respectively. Therefore, Oxyisocyclointegrin and Cyclointegrin show promising potential as natural bioactive compound candidates for further development in natural product-based pharmacotherapy research.
Co-Authors Imaningsih, Witiyasti Nazarni Rahmi, Nazarni Nur, Hasrul Satria Pangestika, Intan Widya Weridyaningrum, Ratu