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All Journal The Journal of Society Medicine (JSOCMED)
Damanik, Rizki amaliah
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Blood Eosinophil Count as a Predictor of Asthma Exacerbation Damanik, Rizki amaliah; Pradana, Andika; Pandia, Pandiaman
Journal of Society Medicine Vol. 4 No. 2 (2025): February
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i2.197

Abstract

Introduction: Asthma is a heterogeneous disease characterized by chronic airway inflammation, where eosinophils play a crucial role. Eosinophil levels are often considered a biomarker for asthma severity and treatment response. However, their relationship with asthma exacerbation severity remains unclear. This study aimed to evaluate the relationship between blood eosinophil levels and the severity of asthma exacerbations in patients at Prof. Dr. Chairuddin P. Lubis USU Hospital. Method: This study employed an analytic observational design with a retrospective cohort approach. Data were collected from 25 asthma patients through medical records, including demographic characteristics, blood eosinophil levels, and asthma exacerbation severity. The relationship between eosinophil levels and exacerbation severity was analyzed using the Whitney test. Results: The majority of asthma patients were in the 26-50 age group (44%) and predominantly female (80%). Most patients had blood eosinophil levels <100 (84%), and severe exacerbations were the most common (72%). Statistical analysis showed no significant relationship between blood eosinophil levels and asthma exacerbation severity (p = 0.976). Conclusion: This study found no significant correlation between blood eosinophil levels and asthma exacerbation severity. Other factors, such as corticosteroid use, delayed immune response, and non-eosinophilic asthma, may influence exacerbation severity. These findings emphasize the importance of a multidimensional evaluation in asthma management, including the identification of different asthma phenotypes to guide more precise treatment strategies.
Analysis of Blood Eosinophil Levels as an Indicator of Controlled Asthma Classification at the University of Sumatra Utara Hospital Damanik, Rizki Amaliah; Pradana, Andika; Pandia, Pandiaman
Journal of Society Medicine Vol. 4 No. 3 (2025): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i3.198

Abstract

Introduction: Asthma is a chronic inflammatory disease of the airways characterized by variable airflow obstruction. Eosinophils play a crucial role in airway inflammation and may serve as a biomarker for asthma control classification. This study aims to analyze the relationship between blood eosinophil levels and asthma control classification in patients at the University of Sumatra Utara Hospital. Methods: This was an analytical observational study with a retrospective cohort approach based on medical records. A total of 25 stable asthma patients who had been receiving inhaled corticosteroid-long-acting beta-agonist (ICS-LABA) therapy for at least one year were included. Data were analyzed using SPSS version 26, and the Kruskal-Wallis test was performed to assess the relationship between eosinophil levels and asthma control classification. Results: The majority of patients were aged 26-50 years (44%) and female (80%). Most patients had eosinophil levels <100 (84%), while 8% had levels between 100-300 and another 8% had levels >300. Regarding asthma control, 46.7% of patients were fully controlled, 43.3% were partially controlled, and 10% were uncontrolled. Statistical analysis showed a significant relationship between eosinophil levels and asthma control classification (p = 0.009), indicating that lower eosinophil levels are associated with better asthma control. Conclusion: The study found that lower eosinophil levels were associated with better asthma control. These findings suggest that blood eosinophil levels may serve as an indicator for assessing asthma control, though further research is needed to confirm this relationship.
Co-Authors Andika Pradana Pandia, Pandiaman