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All Journal Asian Journal of Health Research
Destikatari, Lovin
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pregnancy with Bidirectional Dominant Left-To-Right Shunt due to Ventricular Septal Defect and Large Secundum Atrial Septal Defect with Left-To-Right Shunt: A Case Report Destikatari, Lovin; Prasetyorini, Nugrahanti; Putri, Valerinna Yogibuana Swastika
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.218

Abstract

Introduction: Congenital heart disease (CHD) is the most common birth defect in humans, affecting approximately 0.8% of all live births. The spectrum of defects is broad, ranging from complex defects that lead to severe disability and death in infancy, to mild defects that may only be discovered later in asymptomatic adults. Case Presentation: This case report discusses a 21-year-old female in her second pregnancy was diagnosed with complex congenital heart disease after presenting with shortness of breath. Pulmonary hypertension was established by echocardiography. The woman did not obtain proper therapy since she was not aware of her cardiac problem during her pregnancy. There were no fetal abnormalities found during prenatal exams. At 38 weeks gestation, an IUD-assisted cesarean surgery was scheduled. While a cesarean section is performed on individuals with certain problems, the majority of CHD cases may be successfully delivered vaginally. Another crucial factor to take into account is the choice of postpartum contraception. Conclusion: A personalized strategy is needed to manage congenital heart disease throughout pregnancy. This includes risk education, careful observation, and modification of interventions to guarantee the best possible results for both mother and child.
The Effect of Flavonoids from Mahkota Dewa Fruit Extract (Phaleria macrocarpa) on Inflammation Factors (IL-1β and IL-6) and Estrogen Receptor Alpha (ERα) in The Ovaries of Endometriosis Model Mice Destikatari, Lovin; Rahajeng; Baihaqi, Irfani
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.220

Abstract

Introduction: Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterus. The disease is marked by uncontrolled cell proliferation, increased cell aggressiveness, apoptosis defects, and an inflammatory microenvironment. Phaleria macrocarpaa, a native Indonesian plant, contains flavonoids that function as antioxidants and have anti-inflammatory and antimicrobial properties. Previous research has shown that flavonoids from Phaleria macrocarpa can inhibit endometriosis lesion growth by regulating cell apoptosis. Material and Methods: This study is an experimental study using a randomized post-test-only control group design. Six groups were included: a negative control, a positive control, and four treatment groups receiving Phaleria macrocarpa flavonoid extract at concentrations of 3.75%, 7.5%, 11.25%, and 15%. The primary data obtained were then examined using SPSS 26.0. Results: IL-1β, IL-6, and ERα levels in the treatment groups were lower than in the positive control group, with significant differences between each group. Higher extract doses were associated with a greater reduction in inflammatory mediators. Regression analysis demonstrated a strong correlation between Phaleria macrocarpa extract administration and decreased levels of IL-1β (86%), IL-6 (94%), and ERα (95%). Conclusion: In endometriosis model mice, administering Phaleria macrocarpa fruit extract can lower the concentration of IL-1β, IL-6, and ERα. There is a correlation between the reduction of concentration of IL-1β, IL-6, and ERα in endometriosis model mice and various doses of Phaleria macrocarpa fruit extract.
Co-Authors Baihaqi, Irfani Nugrahanti Prasetyorini Putri, Valerinna Yogibuana Swastika Rahajeng