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All Journal Majalah Obstetri dan Ginekologi Asian Journal of Health Research
Baihaqi, Irfani
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Influence of Vitamin D3 Supplementation on LH and FSH Levels in Female Rats (Rattus norvegicus) with Polycystic Ovary Syndrome (PCOS) Model Gandhari, Anak Agung Sagung Agung Ayuska; Wiyasa, I Wayan Arsana; Hariyati, Suheni Ninik; Baihaqi, Irfani
Asian Journal of Health Research Vol. 2 No. 3 (2023): Volume 2 No 3 (December) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i3.133

Abstract

Introduction: Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder in reproductive-aged women, characterized by hormonal imbalances such as Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). This study investigates the impact of Vitamin D3 supplementation on LH and FSH levels in female rats with a PCOS model. Material and Methods: In this laboratory experiment, female rats were induced with testosterone propionate for 28 days. They were divided into three groups: negative control, positive control (testosterone only), and treatment (testosterone + Vitamin D3 supplementation). LH and FSH levels were measured using the enzyme-linked immunosorbent assay method. Results: The results revealed that Vitamin D supplementation significantly reduced FSH levels in the treatment group compared to the positive control, while it increased FSH levels. Regression analysis demonstrated a negative correlation between Vitamin D supplementation and LH levels, as well as a positive correlation with FSH levels. Conclusion: Vitamin D3 supplementation appears to have a regulatory effect on LH and FSH levels in female rats with PCOS. Future research could explore the impact of higher Vitamin D3 doses and conduct further investigations at advanced stages of PCOS. These findings contribute to our understanding of PCOS and potential interventions involving Vitamin D3.
Curcumin reduces inflammation process in mice model preeclampsia Rahardjo, Bambang; Widyalaksono, Agung; Baihaqi, Irfani
Majalah Obstetri & Ginekologi Vol. 33 No. 1 (2025): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I12025.21-29

Abstract

HIGHLIGHTS Increased oxidative stress results in increased iNOS in pre-eclampsia. COX-2 expression in the placenta of women suffering from preeclampsia increases and is associated with increased thromboxane production.   ABSTRACT Objective: Preeclampsia is one of the most frequently documented pregnancy complications, with a prevalence of approximately 2 to 15% of all pregnancies. Preeclampsia is a leading cause of maternal mortality. According to research in Indonesia, preeclampsia accounts for 66.8% of all cases of hypertension during pregnancy. This research aims to evaluate the impact of curcumin on serum levels of COX-2 and iNOS in a mouse model of preeclampsia. Materials and Methods: This study employed a true experimental design with a post-test-only controlled group approach using pregnant Rattus norvegicus as a preeclampsia model. Curcumin was administered orally via a feeding tube after dissolving powdered tablets. Dosages were 30 mg/day, 50 mg/day, or 100 mg/day, adjusted for the rats' weight. Serum COX-2 and iNOS levels were measured using ELISA kits from Bioassay Technology Laboratory, with concentrations reported in pg/ml. Analysis was performed using SPSS for Windows 19.0. Results: Serum COX-2 levels showed significant differences (p < 0.05) across groups. L-NAME treatment increased COX-2 levels compared to the negative control. Curcumin (50 and 100 mg/kgBW) reduced COX-2 levels significantly compared to the positive control, with no notable differences between curcumin doses. For iNOS levels, significant differences were also found (p < 0.05). Curcumin at 100 mg/kgBW significantly lowered iNOS levels compared to the positive control, with no significant differences between other treatment groups. Conclusion: Curcumin administration effectively reduces COX-2 and iNOS levels in the serum of Rattus norvegicus with a preeclampsia model.
The Effect of Flavonoids from Mahkota Dewa Fruit Extract (Phaleria macrocarpa) on Inflammation Factors (IL-1β and IL-6) and Estrogen Receptor Alpha (ERα) in The Ovaries of Endometriosis Model Mice Destikatari, Lovin; Rahajeng; Baihaqi, Irfani
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.220

Abstract

Introduction: Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterus. The disease is marked by uncontrolled cell proliferation, increased cell aggressiveness, apoptosis defects, and an inflammatory microenvironment. Phaleria macrocarpaa, a native Indonesian plant, contains flavonoids that function as antioxidants and have anti-inflammatory and antimicrobial properties. Previous research has shown that flavonoids from Phaleria macrocarpa can inhibit endometriosis lesion growth by regulating cell apoptosis. Material and Methods: This study is an experimental study using a randomized post-test-only control group design. Six groups were included: a negative control, a positive control, and four treatment groups receiving Phaleria macrocarpa flavonoid extract at concentrations of 3.75%, 7.5%, 11.25%, and 15%. The primary data obtained were then examined using SPSS 26.0. Results: IL-1β, IL-6, and ERα levels in the treatment groups were lower than in the positive control group, with significant differences between each group. Higher extract doses were associated with a greater reduction in inflammatory mediators. Regression analysis demonstrated a strong correlation between Phaleria macrocarpa extract administration and decreased levels of IL-1β (86%), IL-6 (94%), and ERα (95%). Conclusion: In endometriosis model mice, administering Phaleria macrocarpa fruit extract can lower the concentration of IL-1β, IL-6, and ERα. There is a correlation between the reduction of concentration of IL-1β, IL-6, and ERα in endometriosis model mice and various doses of Phaleria macrocarpa fruit extract.
Co-Authors Bambang Rahardjo Destikatari, Lovin Gandhari, Anak Agung Sagung Agung Ayuska Hariyati, Suheni Ninik Rahajeng Widyalaksono, Agung Wiyasa, I Wayan Arsana