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All Journal Jurnal Impresi Indonesia International Journal of Health and Pharmaceutical (IJHP)
Johnson Kepel, Billy
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Religion Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences

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IN VITRO EVALUATION OF THE ANTI-INFLAMMATORY POTENTIAL OF ETHANOL EXTRACT FROM PINK CHRYSANTHEMUM (CHRYSANTHEMUM MORIFOLIUM) Angelique Baya, Gloria Prisca Susana; Ellen Manampiring, Aaltje; Fatimawali, Fatimawali; Budiarso, Hermina; Johnson Kepel, Billy
Jurnal Impresi Indonesia Vol. 4 No. 2 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i2.6305

Abstract

Inflammation is the body's normal response to injury. However, acute and chronic inflammatory reactions can lead to various diseases. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proven effective as anti-inflammatory agents, but excessive and long-term use of NSAIDs can cause various side effects. Pink chrysanthemum flowers (Chrysanthemum morifolium) are one of many medicinal plants used as traditional medicine due to their content of compounds such as flavonoids, triterpenoids, and steroids, which have anti-inflammatory properties and the potential to serve as alternatives to NSAIDs. To identify active compounds and analyze the anti-inflammatory activity of ethanol extract from pink chrysanthemum flowers (Chrysanthemum morifolium). This study is an experimental laboratory research. The extraction method used was Microwave-Assisted Extraction (MAE). The anti-inflammatory activity of the ethanol extract of pink chrysanthemum flowers was measured using the red blood cell membrane stabilization method. The tests were performed using a UV-Vis spectrophotometer at extract concentrations of 50 ppm, 100 ppm, 200 ppm, 400 ppm, and 800 ppm. Pink chrysanthemum flowers contain several phytochemical compounds, including alkaloids, flavonoids, tannins, triterpenoids/steroids, and phenolics. The anti-inflammatory activity measurement showed that higher extract concentrations resulted in lower absorbance values and increased stabilization percentages, indicating anti-inflammatory activity that protects red blood cell membranes from damage. The ethanol extract of pink chrysanthemum flowers contains several phytochemical compounds with potential anti-inflammatory activity. The extract at a concentration of 800 ppm demonstrated the highest membrane stabilization ability, with a stabilization rate of 59.459%.
Factors Associated with Rabies Antibody Titers in Dogs in Mapanget District, Manado City Rosalin Hutasoit, Dimitris; Johnson Kepel, Billy; Iren Christy Manoppo, Jeanette
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 1 (2026): February 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i1.522

Abstract

Rabies remains a highly fatal zoonotic disease and continues to pose a substantial public health challenge in Indonesia, including in Manado City. Mapanget District hosts a considerable dog population, yet empirical data on herd immunity based on rabies antibody titers are scarce. This study aimed to evaluate the determinants associated with rabies antibody titers among dogs in Mapanget District, Manado City. A cross-sectional study was conducted involving 97 dogs selected through purposive sampling. Serum samples were analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) to classify antibody titers as protective (≥0.5 IU/mL) or non-protective (<0.5 IU/mL). Statistical analyzes included Fisher's Exact Test and multivariable logistic regression to assess associations between host factors and antibody titer status. Only 8.2% of dogs exhibited protective antibody titers, whereas 91.8% demonstrated non-protective levels. Vaccination status showed a highly significant association with antibody titers (p < 0.001). Vaccinated dogs were markedly more likely to achieve protective titers compared to unvaccinated dogs (OR = 35.71; 95% CI: 3.888–328.026). No significant associations were observed for dog type, age, or sex (p > 0.05). The findings underscore a critically low level of immunity within the dog population in Mapanget District, primarily attributable to insufficient vaccination coverage. Vaccination emerged as the predominant factor influencing the development of protective antibody titers. Strengthening routines and mass vaccination programs, coupled with systematic serological monitoring, are imperative to achieve adequate herd immunity and to advance rabies elimination strategies in the region.
Co-Authors Angelique Baya, Gloria Prisca Susana Budiarso, Hermina Ellen Manampiring, Aaltje Fatimawali . Iren Christy Manoppo, Jeanette Rosalin Hutasoit, Dimitris