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Nugrohowati, Noviana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Discordance of HER2 between primary tumors and lymph node metastatic lesions in invasive breast cancer Nugrohowati, Noviana; Anwar, Sumadi Lukman; Juwaryani, Juwaryani; Ridhayani, Firda
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.43-49

Abstract

BackgroundBreast cancer therapy is mostly influenced by the type and molecular subtype, especially in the case of human epidermal growth factor receptor 2 (HER2) status, where HER2-positive patients will receive anti-HER2 therapy. HER2 status is obtained from HER2 immunohistochemistry examination which can be performed on primary breast tumors or lymph node metastatic lesions. This study aimed to determine the concordance of HER2 status between primary tumors and lymph node metastatic lesions in invasive breast cancer. MethodsA cross-sectional study was conducted involving 30 invasive breast cancer patients. HER2 immunohistochemistry examination was carried out on both the primary tumor and lymph node metastatic lesions. The Cohen κ coefficient was used to analyse the data. Results The concordance rate for HER2 was 86.67%. Thirteen cases were concordantly HER2-negative in primary breast cancer (BC) and nodal metastases, and 13 cases were HER2-positive in both primary and metastatic tumors. Changes in HER2 status between primary BC and corresponding synchronous metastases were observed in four (4.72%) cases. One of the discordant cases was HER2-negative in the primary tumor and HER2-positive in the metastases, while three cases were HER2-positive in the primary breast cancer and HER2- negative in the metastases. Conclusion There is a discordance of HER2 status between the primary tumor and lymph node metastases in invasive breast cancer patients. It is necessary to evaluate the HER2 status of the primary tumor and metastases simultaneously. Such an evaluation is recommended for better prognosis and survival.
Association between p53 Status and Breast Cancer Molecular Subtypes in the Academic Hospital of Universitas Gadjah Mada: p53 Status in Breast Carcinoma Nugrohowati, Noviana; Setyowati, Mila E.; Kusuma, Tania
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.964.59

Abstract

Breast cancer is the most common form of cancer and the leading cause of mortality in women. The p53 pathway is crucial for cell cycle regulation and tumor development. Alterations in the p53 are associated with increased aggressiveness of cancer cells. This cross-sectional study explored the association between p53 status and the molecular subtypes of invasive breast cancer in patients at the Academic Hospital of Universitas Gadjah Mada from 2016 to 2024. Immunohistochemical analysis was conducted to evaluate the presence of mutant p53 in primary tumor specimens. Of the p53-negative tumors in this study, 4 patients were triple-negative breast cancer. No association was observed between p53 expression and molecular subtype, with p-values of 0.16 and 0.224. In contrast, a significant correlation was noted between p53 and Ki67 expression, resulting in a coefficient of 0.513 (p=0.009). Additionally, a notable correlation of 0.531 was found between p53 expression and tumor size (p=0.006). In conclusion, tumor size is a crucial parameter for determining patient prognosis; specifically, as tumor size increases, p53 expression also rises, leading to a worse prognosis.
Co-Authors Anwar, Sumadi Lukman Firda Ridhayani Juwaryani, Juwaryani Kusuma, Tania Setyowati, Mila E.