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All Journal Open Access Indonesian Journal of Medical Reviews
Prima Budi Prayogi
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Health Professions Medicine & Pharmacology

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Neutrophil-Lymphocyte Ratio as a Predictor of Ulcer Severity in Type 2 Diabetes Prima Budi Prayogi; Prima Kharisma Hayuningrat; Suharto Wijanarko; Hari Wujoso
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 3 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i3.718

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with increasing global prevalence, frequently complicated by foot ulcers. These ulcers present a significant burden, often leading to amputation and increased mortality. The neutrophil-lymphocyte ratio (NLR), a readily available marker of systemic inflammation, has emerged as a potential prognostic indicator in various diseases. This study investigated the correlation between NLR and the severity of foot ulcers in patients with T2DM. A retrospective, cross-sectional study was conducted, analyzing data from 60 patients with T2DM and foot ulcers admitted to Dr. Moewardi General Hospital, Surakarta, between January 1st, 2022, and December 31st, 2023. NLR was calculated from routine complete blood counts. Ulcer severity was graded using the Meggitt-Wagner classification. Statistical analysis included Spearman's rank correlation and Kruskal-Wallis tests. Our study found a significant correlation observed between NLR and ulcer severity (ρ = 0.524, p < 0.001), with NLR values increasing with ulcer grade. Amputation was significantly associated with ulcer severity (p=0.009). In conclusion, NLR is a valuable and readily available biomarker for assessing the severity of foot ulcers in patients with T2DM. Elevated NLR is associated with more severe ulcers and a higher likelihood of amputation. Incorporating the assessment of NLR into the routine evaluation of patients with diabetic foot ulcers can aid in risk stratification and guide clinical management.
Atypical Presentation of Cerebellopontine Angle Dermoid Cyst: A Case of Secondary Trigeminal Neuralgia Prima Budi Prayogi; Galih Indra Permana; Hanis Setyono; Ferry Wijanarko; Geizar Arsika Ramadhana; Muhammad Fauzan Jauhari
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 4 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i4.753

Abstract

Dermoid cysts are rare congenital ectodermal inclusion cysts, accounting for a small percentage of all intracranial tumors. Their occurrence in the cerebellopontine angle (CPA) is infrequent, and presentation as isolated trigeminal neuralgia (TN) is considered atypical. This study underscores that rare congenital lesions like dermoid cysts can manifest with relatively common neurological symptoms, prompting clinicians to consider a broader differential diagnosis A 60-year-old female presented with a two-year history of paroxysmal, shock-like pain in the left cheek and intraoral area, triggered by light touch, consistent with trigeminal neuralgia. Neurological examination was otherwise largely unremarkable initially, though the pain significantly impacted her quality of life and nutritional intake, leading to weight loss. Magnetic Resonance Imaging (MRI) revealed an extra-axial lesion in the CPA, compressing the trigeminal nerve. The lesion exhibited characteristics suggestive of an epidermoid or arachnoid cyst initially, but with features also compatible with a dermoid cyst. The patient underwent a retrosigmoid craniotomy for microsurgical excision of the lesion. Intraoperatively, a cystic lesion with contents suggestive of a dermoid cyst was found adherent to the trigeminal nerve and surrounding structures. Histopathological examination confirmed the diagnosis of a dermoid cyst. Postoperatively, the patient experienced significant relief from her trigeminal neuralgia. In conclusion, CPA dermoid cysts, though rare, should be considered in the differential diagnosis of secondary trigeminal neuralgia, even in atypical presentations. MRI is crucial for diagnosis, and surgical excision aiming for maximal safe resection is the mainstay of treatment, offering potential for symptom resolution. Long-term follow-up is necessary due to the potential for recurrence if the residual cyst wall remains. This case underscores the importance of considering rare pathologies in common clinical presentations.
Co-Authors Ferry Wijanarko Galih Indra Permana Geizar Arsika Ramadhana Hanis Setyono Hari Wujoso Muhammad Fauzan Jauhari Prima Kharisma Hayuningrat Suharto Wijanarko