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All Journal Nexus Biomedika Devotion: Journal of Research and Community Service Open Access Indonesian Journal of Medical Reviews Jurnal Sains dan Kesehatan Tama: Journal of Visual Arts
Galih Indra Permana
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology

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Uji Sitotoksik Ekstrak Biji Pare (Momordica charantia L.) pada Kultur Sel Limfosit T Pasien LES In Vitro Permana, Galih Indra; Balgis, .; Mujosemedi, .
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease, mediated by lymphocytes. Wrong regulation in immune system causes autoreactivity of T lymphocytes and hyperactivity of B lymphocytes then causes inflammation in site organ. Extract of bitter melon seeds contains ribosome inactivating proteins (RIPs), momordin I, and momordin II which can induce apoptosis in the cells and have cytotoxic effects. This study is to examine the cytotoxic effects of bitter melon seeds extract on cultured T lymphocytes of SLE patient in vitro. Methods: This study was an experimental laboratory research with posttest control group design. Sample was culture of T lymphocytes from SLE patient with the active phase. T lymphocytes culture was divided in four groups that were bitter melon seeds extract, cyclophosphamide, control media, and control cells. Cytotoxic effects were measured with MTT assay then the data were analyzed with statistical regression analysis to determine the IC50. Results: IC50 of bitter melon seeds extract on culture of T lymphocytes cell of SLE patient was 1704.07 µg/ml and normal sample was 19.20 µg/ml. While IC50 of cyclophosphamide for treatment of SLE sample was 16.80 µg/ml and for normal sample was 39.24 µg/ml. Extract of bitter melon seeds had weak cytotoxic effect on T lymphocyte cell culture of SLE patient and moderately active cytotoxic effect on T lymphocyte cell culture of normal sample. Conclusion: Extract of bitter melon seeds had weak cytotoxic effects on T lymphocyte cell culture of SLE patient with IC50 was 1704.07 µg/ml. Keywords: SLE, bitter melon seed extract, cytotoxic, lymphocytes T
Uji Sitotoksik Ekstrak Biji Pare (Momordica charantia L.) pada Kultur Sel Limfosit T Pasien LES In Vitro Galih Indra Permana; . Balgis; . Mujosemedi
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease, mediated by lymphocytes. Wrong regulation in immune system causes autoreactivity of T lymphocytes and hyperactivity of B lymphocytes then causes inflammation in site organ. Extract of bitter melon seeds contains ribosome inactivating proteins (RIPs), momordin I, and momordin II which can induce apoptosis in the cells and have cytotoxic effects. This study is to examine the cytotoxic effects of bitter melon seeds extract on cultured T lymphocytes of SLE patient in vitro. Methods: This study was an experimental laboratory research with posttest control group design. Sample was culture of T lymphocytes from SLE patient with the active phase. T lymphocytes culture was divided in four groups that were bitter melon seeds extract, cyclophosphamide, control media, and control cells. Cytotoxic effects were measured with MTT assay then the data were analyzed with statistical regression analysis to determine the IC50. Results: IC50 of bitter melon seeds extract on culture of T lymphocytes cell of SLE patient was 1704.07 g/ml and normal sample was 19.20 g/ml. While IC50 of cyclophosphamide for treatment of SLE sample was 16.80 g/ml and for normal sample was 39.24 g/ml. Extract of bitter melon seeds had weak cytotoxic effect on T lymphocyte cell culture of SLE patient and moderately active cytotoxic effect on T lymphocyte cell culture of normal sample. Conclusion: Extract of bitter melon seeds had weak cytotoxic effects on T lymphocyte cell culture of SLE patient with IC50 was 1704.07 g/ml. Keywords: SLE, bitter melon seed extract, cytotoxic, lymphocytes T
Atypical Presentation of Cerebellopontine Angle Dermoid Cyst: A Case of Secondary Trigeminal Neuralgia Prima Budi Prayogi; Galih Indra Permana; Hanis Setyono; Ferry Wijanarko; Geizar Arsika Ramadhana; Muhammad Fauzan Jauhari
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 4 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i4.753

Abstract

Dermoid cysts are rare congenital ectodermal inclusion cysts, accounting for a small percentage of all intracranial tumors. Their occurrence in the cerebellopontine angle (CPA) is infrequent, and presentation as isolated trigeminal neuralgia (TN) is considered atypical. This study underscores that rare congenital lesions like dermoid cysts can manifest with relatively common neurological symptoms, prompting clinicians to consider a broader differential diagnosis A 60-year-old female presented with a two-year history of paroxysmal, shock-like pain in the left cheek and intraoral area, triggered by light touch, consistent with trigeminal neuralgia. Neurological examination was otherwise largely unremarkable initially, though the pain significantly impacted her quality of life and nutritional intake, leading to weight loss. Magnetic Resonance Imaging (MRI) revealed an extra-axial lesion in the CPA, compressing the trigeminal nerve. The lesion exhibited characteristics suggestive of an epidermoid or arachnoid cyst initially, but with features also compatible with a dermoid cyst. The patient underwent a retrosigmoid craniotomy for microsurgical excision of the lesion. Intraoperatively, a cystic lesion with contents suggestive of a dermoid cyst was found adherent to the trigeminal nerve and surrounding structures. Histopathological examination confirmed the diagnosis of a dermoid cyst. Postoperatively, the patient experienced significant relief from her trigeminal neuralgia. In conclusion, CPA dermoid cysts, though rare, should be considered in the differential diagnosis of secondary trigeminal neuralgia, even in atypical presentations. MRI is crucial for diagnosis, and surgical excision aiming for maximal safe resection is the mainstay of treatment, offering potential for symptom resolution. Long-term follow-up is necessary due to the potential for recurrence if the residual cyst wall remains. This case underscores the importance of considering rare pathologies in common clinical presentations.
Uji Senyawa Kuersetin dari Ekstrak Bajakah Tampala (Spatholobus littoralis Hassk.) Menggunakan High Performance Liquid Chromatography: Analysis of Quercetin Compound from Extract of Bajakah Tampala (Spatholobus littoralis Hassk.) Using High Performance Liquid Chromatography Munthe, Ervi Audina; Bakring, Abi; Irfan, Ihsanul; Permana, Galih Indra
Jurnal Sains dan Kesehatan Vol. 7 No. 4 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i4.2492

Abstract

Bajakah tampala (Spatholobus littoralis Hassk) is a plant that grows wild in the forests of Central Kalimantan. Bajakah tampala is a natural resource with potential antioxidant and anti-inflammatory properties. Previous phytochemical research on bajakah tampala stem extract revealed the presence of flavonoid metabolites, alkaloids, tannins, saponins, steroids, triterpenoids, and polyphenols. This study aims to analyze the flavonoid compound quercetin in the ethanol extract of bajakah tampala (Spatholobus littoralis Hassk) using HPLC analysis method. In this study, qualitative and quantitative phytochemical tests were conducted on the 96% ethanol extract of bajakah tampala. The results showed that the 96% ethanol extract of bajakah tampala contains flavonoids and tannins in the qualitative test, while the quantitative test indicated a longer retention time (RT) if the analyte has a higher affinity for the stationary phase, with bajakah tampala showing an RT of 6.639 minutes. The detected quercetin content was 17.54 ppm, indicating a relatively low concentration of quercetin. Keywords:          bajakah tampala, quercetin, flavonoid, tannin   Abstrak Bajakah tampala (Spatholobus littoralis Hassk) merupakan tanaman yang tumbuh liar di hutan Kalimantan Tengah. Bajakah tampala adalah salah satu sumber alam yang berpotensi sebagai antioksidan dan antiinflamasi. Adapun fitokimia penelitian sebelumnya ekstrak batang bajakah tampala mengandung senyawa metabolit flavonoid, alkaloid, tanin, saponin, steroid dan triterpenoid serta polifenol Penelitian ini bertujuan menganalisis senyawa flavonoid kuarsetin dari ekstrak etanol bajakah tampala (Spatholobus littoralis Hassk) menggunakan metode analisis HPLC. Pada penelitian ini dilakukan uji fitokimia kualitatif dan kuantitatif dari ekstrak etanol 96% bajakah tampala. Hasil penelitian menunjukkan bahwa ekstrak etanol 96% bajakah tampala untuk uji kualitatif mengandung flavonoid, tanin dan saponin sedangkan uji kuantitatif menunjukkan waktu retensi (RT) lebih panjang jika analit memiliki afinitas yang lebih tinggi terhadap fase diam pada bajakah tampala dengan RT 6,639 menit dan kadar kuersetin yang terdeteksi adalah 17.54 ppm maka memiliki kadar quersetin yang relatif rendah. Kata Kunci:         bajakah tampala, kuersetin, flavonoid, tanin
Efficacy Of Ertugliflozin Compared With Metformin Or Placebo In Reducing Hba1c Levels Among Adults With Type 2 Diabetes: A Systematic Review And Meta-Analysis Permana, Galih Indra; Munthe, Ervi Audina; Irfan, Ihsanul
Devotion : Journal of Research and Community Service Vol. 6 No. 10 (2025): Devotion: Journal of Community Research
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v6i10.25569

Abstract

Type 2 diabetes mellitus (T2DM) remains a global health challenge characterized by chronic hyperglycemia due to insulin resistance and impaired insulin secretion. Glycemic control, measured by glycated hemoglobin (HbA1c), is a crucial indicator of therapeutic effectiveness. This systematic review and meta-analysis aim to compare the efficacy of Ertugliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, with Metformin and Placebo in reducing HbA1c levels among adults with T2DM. Relevant randomized controlled trials (RCTs) published between 2015 and 2025 were identified through PubMed, Scopus, and Cochrane databases. Data extraction and quality assessment followed PRISMA guidelines. The pooled analysis demonstrated that Ertugliflozin significantly reduced HbA1c levels compared to placebo, with mean differences ranging from −0.6% to −1.0% (p < 0.001). When compared to Metformin, Ertugliflozin showed comparable glycemic efficacy, with additional benefits in weight reduction and blood pressure control. Heterogeneity among studies was moderate (I² < 50%), and no severe adverse effects were reported. These findings suggest that Ertugliflozin is an effective and safe alternative or adjunct therapy for adults with T2DM, offering multifaceted metabolic benefits beyond glucose control.
Enhancing 3R (Reuse, Reduce, Recycle) Awareness through E-Book Design as a Sustainable Waste Management Solution Permana, Galih Indra
TAMA: Journal of Visual Arts Vol. 4 No. 1 (2026): Vol. 4 No. 1 (2026): TAMA: JOURNAL OF VISUAL ART VOLUME 4 NO. 1 APRIL 2026
Publisher : Faculty Of Arts and Design Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61405/78005x11

Abstract

This study entitled “Enhancing 3R (Reuse, Reduce, Recycle) Awareness through E-Book Design as a Sustainable Waste Management Solution” focuses on the development of an educational e-book aimed at increasing public awareness of 3R practices in Indonesia, with Surakarta City as one of the case examples. This research is motivated by the low level of public understanding and implementation of sustainable waste management practices in various regions of Indonesia. The purpose of this study is to design an e-book based on visual communication design principles that is visually engaging, easy to understand, and capable of encouraging the application of the 3R (Reuse, Reduce, Recycle) concept in daily life. A qualitative research methodology was employed, including observation, interviews, questionnaires, and literature review. The results indicate that informative, interactive, and visually consistent visual content delivered through e-book media can effectively enhance public understanding and interest in implementing 3R principles. Therefore, the designed e-book is expected to strengthen public awareness at the national level and serve as an effective educational medium to promote sustainable waste management behavior in Indonesia.   Keywords: 3R Awareness, E-book Design, Sustainable Waste Management, Visual Communication Design  
Co-Authors . Balgis . Mujosemedi Bakring, Abi Balgis . Ervi Audina Munthe Ferry Wijanarko Geizar Arsika Ramadhana Hanis Setyono Irfan, Ihsanul Muhammad Fauzan Jauhari Munthe, Ervi Audina Prima Budi Prayogi