Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Care : Jurnal Ilmiah Ilmu Kesehatan MEDICA (International Medical Scientific Journal)
Ratulangi, Agus Dimas
Unknown Affiliation
Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Relationship Between NS1 Examination and the Examination of Hemoglobin, Hematocrit, Leukocytes, Platelets, and Erythrocytes in Dengue Fever Patients in The Pediatric Ward Ratulangi, Agus Dimas; Djohan, Herlinda; Kamilla, Laila
MEDICA (International Medical Scientific Journal) Vol. 7 No. 1 (2025): MEDICA (International Medical Scientific Journal)
Publisher : Borneo Scientific Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53770/medica.v7i1.486

Abstract

The NS1 antigen test is developed to detect dengue virus infection during the acute phase, a stage marked by various hematological abnormalities. An increase in hemoglobin levels greater than 20% can support the diagnosis of Dengue Hemorrhagic Fever (DHF), often caused by hemoconcentration due to plasma leakage, which also raises erythrocyte levels in the bloodstream. This study aimed to examine the relationship between NS1 test results and hemoglobin, hematocrit, leukocyte, platelet, and erythrocyte levels in pediatric DHF patients at Dr. Soedarso Regional Hospital. Using a cross-sectional design with total sampling, 203 samples were collected from suspected pediatric DHF patients between May and July 2023. Data included NS1 results and hematology parameters. The analysis showed a significant association between positive NS1 results and hemoglobin levels (p = 0.025) as well as platelet counts (p = 0.035), but no significant relationship with hematocrit (p = 0.872), leukocytes (p = 0.269), or erythrocytes (p = 0.060). In conclusion, NS1 positivity is significantly associated with hemoglobin levels and platelet count, but not with hematocrit, leukocytes, or erythrocytes in pediatric DHF patients.
Predictors of Dengue Hemorrhagic Fever in the Pediatric Population: Logistic Regression Analysis of Hematological Profile and Demographics Nuswantoro, Ari; Ratulangi, Agus Dimas
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 14, No 1 (2026): EDITION MARCH 2026
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v14i1.8398

Abstract

Dengue Hemorrhagic Fever (DHF) remains a significant public health threat in Indonesia, particularly among the pediatric population. Early diagnosis is crucial for appropriate clinical management, and hematological parameters are routinely available indicators that may aid in predicting dengue infection. However, the independent predictive value of individual hematological parameters for NS1-confirmed dengue in children remains not fully characterized. This study aimed to identify independent predictors of NS1-positive dengue hemorrhagic fever in the pediatric population through logistic regression analysis of hematological profiles and demographic characteristics. A cross-sectional analytical study was conducted using secondary data from medical records of pediatric patients admitted to the pediatric ward of RSUD dr. Soedarso Pontianak between January and December 2023. A total of 203 patients who underwent NS1 antigen testing and complete hematological examinations were included. Data were analyzed using bivariate tests (independent t-test or Mann-Whitney U test) followed by binary logistic regression to identify independent predictors of NS1 positivity. Model performance was evaluated using Receiver Operating Characteristic (ROC) curve analysis. Bivariate analysis revealed that thrombocyte count was significantly lower in NS1-positive patients compared to NS1-negative patients. In multivariate logistic regression analysis, thrombocyte count emerged as a significant negative predictor of NS1 positivity, while erythrocyte count demonstrated a significant positive association. Hemoglobin, hematocrit, leukocyte count, age, and sex did not retain statistical significance in the final model. The combination of thrombocyte and erythrocyte counts yielded acceptable discriminative ability with an area under the ROC curve of 0.68. Thrombocyte count and erythrocyte count are independent predictors of NS1-positive dengue infection in pediatric patients. Low thrombocyte counts and elevated erythrocyte counts increase the likelihood of acute dengue infection and should be considered in diagnostic assessment, particularly in resource-limited settings where immediate NS1 testing may not be available.
Co-Authors Ari Nuswantoro Djohan, Herlinda Laila Kamilla