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Herwiningsih, S.
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Energy Physics

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Evaluation of Tumor Control Probability and Normal Tissue Complication Probability of Breast Cancer Treatment Plan in Post Mastectomy Radiation Therapy Herwiningsih, S.; Yuana, F.; Latifah, R.; Hidayat, A.; Rahmahtullah, D. P.; Alviani, I.; Hentihu, F. K.
Atom Indonesia Vol 50, No 2 (2024): AUGUST 2024
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/aij.2024.1423

Abstract

Radiotherapy has been widely used to treat cancer, including breast cancer treatment, which can be given after patients undergo mastectomy procedures. This study aims to evaluate tumor control probability (TCP) and normal tissue complication probability (NTCP) of three-dimensional conformal radiation therapy (3DCRT) and intensity modulated radiation therapy (IMRT) treatment planning in post-mastectomy breast cancer radiation therapy. Twenty clinical breast cancer treatment plans delivered using 3DCRT were evaluated retrospectively. The IMRT plans were created for the same patients. The dose-volume histograms of each plan were extracted from the Treatment Planning System (TPS) computer which were then used to compute the TCP and NTCP for each plan. The TCP was calculated using the Poisson model and the NTCP was calculated using the Lyman-Kutcher-Burman (LKB) model. The NTCP was calculated for normal lung tissue, heart, esophagus, and spinal cord. The results show that the TCP of the 3DCRT and IMRT plans are not significantly different, with a value of above 99 %. The NTCP of the left lung is lower in the IMRT plans while the NTCP of the esophagus is lower in the 3DCRT plans. The NTCP for the heart, spinal cord, and right normal lung are zero in all plans.
Optimizing Quality Assurance in Breast IMRT Treatment Plans: A Comparative Study of Point Dose and 2D Dose Verification Herwiningsih, S.; Noor, J. A. E.; Widodo, C. S.; Munthe, D. Y. B.; Hentihu, F. K.
Atom Indonesia ARTICLE IN PRESS
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Intensity-Modulated Radiation Therapy (IMRT) requires rigorous dose verification to ensure accurate radiation delivery. This study evaluates point dose verification and 2D dose verification techniques in detecting dose discrepancies due to isocenter shifts in IMRT treatment for post-mastectomy breast cancer cases. Five post-mastectomy breast IMRT plans were retrospectively analyzed, with phantom-based measurements compared against Treatment Planning System (TPS) calculations. The results indicate that point dose verification provides reliable absolute dose measurements, but lacks spatial resolution, whereas 2D verification captures dose variations more effectively. Dose discrepancies remained within acceptable limits for shifts up to ±3 mm, but shifts of ±5 mm or more resulted in clinically significant deviations. Gamma Passing Rates (GPR) decreased substantially beyond ±5 mm shifts, underscoring the importance of precise patient positioning. These findings support the integration of both verification methods to improve IMRT quality assurance, particularly in resource-limited settings. Future advancements in AI-driven dosimetry and real-time in vivo monitoring may further optimize dose verification, enhancing treatment accuracy and patient safety.
Co-Authors A. Hidayat Alviani, I. Hentihu, F. K. J. A. E. Noor Latifah, R. Munthe, D. Y. B. Rahmahtullah, D. P. Widodo, C. S. Yuana, F.