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EL Mahjoub, C.
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Energy Physics

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Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code AL-suhbani, M. N.; Baghous, N. E. H.; Serag, S.; EL Mahjoub, C.; Ait-Mlouk, L.; Zia, A.; Hamid, B.; Azougagh, M.
Atom Indonesia VOL 50, NO 1 (2024): APRIL 2024
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/aij.2024.1305

Abstract

Despite the progress of science in cancer treatments and radiotherapy improvements, there are still several side effects that occur during tumors treatment, particularly on healthy tissues surrounded tumors. Newer treatment methods are being explored lately, one of which is the use of nanoparticles, wherein the tumor is injected with gold nanoparticles. Its aim is to enhance tumor sensitivity to radiation and reduce radiation damage to healthy tissues. Tissue type may play an effective role in enhancing the dose being received under the use of nanoparticles. This study aims to find the effect of different tissue components on dose enhancement factor through MCNP6 and GATE simulations, as well as to accurately compare  the simulation results of these two code packages for dose enhancement factors. A 125I brachytherapy source was simulated in phantoms for five tissues or materials (adipose tissue, breast tissue, soft tissue, water, and brain tissue). MCNP6 simulation code was validated by comparing its results with a previous study by Cho et al. Gold nanoparticles were injected as a mixture at a concentration of 7 mg/g into tissues inside a tumor. MCNP6 and GATE simulation results were compared. It was estimated from MCNP simulations that the highest radiation dose enhancement of 2.34 occurs in adipose tissue while lowest dose enhancement of 1.69 is in brain. In comparison, from GATE results, the estimates were that the highest value of dose enhancement factor also occurred in adipose tissue at 2.01, and the lowest value in brain at 1.48. The comparison between two codes suggest that they are compatible with the percentage difference in all tissues being less than 15 %. This study confirms that both MCNP6 and GATE codes could calculate DEF for different tissues under irradiation from a low-energy source.
Carbone or Oxygen Therapy: A Comparative Dosimetric Study Using PHITS Code El Bekkouri, H.; Al Ibrahmi, E.; El-Asery, M.; Bardane, A.; El Mahjoub, C.; Didi, A.; Sadoune, Z.
Atom Indonesia Vol 50, No 2 (2024): AUGUST 2024
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/aij.2024.1352

Abstract

Compared to conventional radiotherapy (X-rays or γ-rays), charged particle therapy shows more potential in treating deep-seated and radio-resistant tumors. Currently, all centers that offer hadron therapy use proton or 12C ion. Ongoing research is exploring the possibility of using others heavier ions, such as oxygen ion 16O or helium ion 4He. In this study, Monte Carlo method was used employing the Particle and Heavy Ion Transport code System (PHITS), to examine the amount of dose deposited by incident particles of 12C ion with energies of 200 and 300 MeV/u, as well as 16O ions with energies of 237.5 and 358.5 MeV/u. In this study, we investigated the depth dose distribution of carbon and oxygen ion beams by comparing their energy deposition in a water phantom and the impact of secondary particles. When considering lower energies, oxygen ions are more advantageous than carbon ions as they have slightly higher peak input ratios. This property enables higher doses to be delivered to tumor targets or lower doses to healthy surrounding tissues.
Bibliometric Analysis of the Literature on Carbon Ion Therapy Using VOSviewer Software and Dimensions Database El Bekkouri, H.; Al Ibrahmi, E.; El-Asery, M.; Bardane, A.; Didi, A.; El Mahjoub, C.; Sadoune, Z.
Atom Indonesia Vol 50, No 2 (2024): AUGUST 2024
Publisher : National Research and Innovation Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/aij.2024.1392

Abstract

This study aims to carry out a bibliometric assessment of the worldwide research literature and historical research results on carbon ion therapy for cancer treatment. To carry out this work, we used the VOSviewer software and the Dimensions database. The VOSviewer software tool examined 2,500 publications exported from the Dimensions database. The results show a notable upward trajectory in academic research on carbon ion therapy since 1994, with 2020 showing the highest volume of publications. “Biomedical and Clinical Sciences”, “Physical Sciences”, “Oncology and Carcinogenesis”, and “Medical and Biological Physics” are the most important research categories. “Physics in Medicine and Biology” and “Medical Physics” are the leading journals for research publications on carbon ion therapy. Scrutiny based on term occurrences demonstrates the shift in research interest towards carbon ion radiation therapy. The analysis of bibliographic couplings concerning different countries revealed that Japan is the most dynamic and prolific country based on the number of publications (659) and citations (13734), followed by Germany with 590 publications and 19679 citations. These analytical studies provide a thorough overview of academic publications dedicated to using carbon ions for tumor treatment. This data is anticipated to be highly valuable for researchers seeking to pinpoint the most recent developments and emerging trends in this field of research.
Co-Authors Ait-Mlouk, L. Al Ibrahmi, E. AL-suhbani, M. N. Azougagh, M. Baghous, N. E. H. Bardane, A. Didi, A. El Bekkouri, H. El-Asery, M. Hamid, B. Sadoune, Z. Serag, S. Zia, A.