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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Abdimas Indonesia
Feri Kanti Rahayu
STIKes Ibnu Sina Ajibarang
Chemistry Computer Science & IT Economics, Econometrics & Finance Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Penyuluhan Pemanfaatan Tanaman Obat untuk Pencegahan dan Pengobatan Penyakit Diabetes Melitus di Desa Sambirata, Cilongok Feri Kanti Rahayu; Indira Pipit Miranti; Iva Rinia Dewi; Mauliana Khoerun Nisa
jurnal ABDIMAS Indonesia Vol. 4 No. 1 (2026): Mei : Jurnal ABDIMAS Indonesia
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jai.v4i1.3723

Abstract

Diabetes Mellitus merupakan salah satu penyakit degeneratif dengan prevalensi yang terus meningkat, terutama pada kelompok usia lanjut. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan masyarakat mengenai pencegahan dan pengelolaan diabetes melitus melalui edukasi pola hidup sehat dan pemanfaatan tanaman obat. Kegiatan dilaksanakan di Desa Sambirata dengan sasaran ibu-ibu Posyandu Lansia. Metode yang digunakan meliputi penyuluhan kesehatan, pemeriksaan tekanan darah, pemeriksaan gula darah sewaktu, dan edukasi pemanfaatan tanaman obatantidiabetes. Sebanyak 44 peserta mengikuti kegiatan penyuluhan dan 71 peserta mengikuti pemeriksaan kesehatan. Hasil pemeriksaan menunjukkan 29 peserta mengalami hipertensi, 3 peserta memiliki kadar gula darah di atas normal, dan 50 peserta memiliki faktor risiko diabetes melitus. Kegiatan ini meningkatkan pengetahuan dan kesadaran masyarakat mengenai pentingnya pola hidup sehat serta penggunaan tanaman obat secara rasional dalam pencegahan diabetes melitus.
Computational Analysis of Biflavonoid Derivatives through Molecular Docking on ALK Kinase Receptor as Potential Inhibitors of A549 Cell Proliferation Feri Kanti Rahayu; Arinda Nur Cahyani; Syaiful Prayogi; Dossy Susan Anggraeni; Putri Aulia Zahra; Azzahra Rhisma Ernanda; Indah Fajar Falupi; Dila Rahma
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.678

Abstract

Lung cancer remains one of the leading causes of cancer-related mortality worldwide. In Indonesia, it ranks third after cervical and breast cancers, with non-small-cell lung carcinoma (NSCLC) being the most prevalent type, accounting for 85–88% of cases. Anaplastic lymphoma kinase (ALK) is a key molecular target in NSCLC, contributing significantly to carcinogenesis. However, resistance to current ALK-targeted therapies poses a major challenge. To address this, new drug discovery efforts are urgently needed. While drug development is typically time-consuming and costly, Computer-Aided Drug Design (CADD) offers an efficient strategy at the early stages. Biflavonoid derivatives have shown anticancer potential but are limited by poor solubility and low activity, warranting further optimization. This study explores structural modifications of biflavonoid derivatives to identify potential ALK inhibitors. The results indicate that the modified compounds (Compounds A and B) demonstrated binding affinities comparable to the reference drug, Entrectinib, suggesting their promise as novel anticancer candidates.
Co-Authors Arinda Nur Cahyani Azzahra Rhisma Ernanda Dila Rahma Dossy Susan Anggraeni Indah Fajar Falupi Indira Pipit Miranti Iva Rinia Dewi Mauliana Khoerun Nisa Putri Aulia Zahra Syaiful Prayogi