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CAR-T-ICI: Kombinasi chimeric antigen receptor T-cell dengan immune checkpoint inhibitor anti PD-1 selaku pilihan terapi terbaru kanker kolorektal: kombinasi chimeric antigen receptor T-cell dengan immune checkpoint inhibitor anti PD-1 selaku pilihan terapi terbaru kanker kolorektal imam hermansyah; Eddy Zulfikar
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.339

Abstract

ABSTRACT Background: Colorectal cancer (CRC) as the third most common malignancy in the world is generally treated by surgery, radiotherapy, or chemotherapy based on the stage of the cancer. However, due to the invasive procedures and adverse reactions, scientists are developing treatment advancements with immunotherapy, especially Chimeric Antigen Receptor (CAR) T-cell which is considered more specific to tumor cells. However, the effectiveness of CART-T cells to treat solid tumors is still limited by Programmed Cell Death-1 (PD-1) through its immunosuppressive effect on T cells, hence the addition of anti PD-1 to CAR-T cells treatment is deemed necessary to increase its therapeutic potential. Objective: To discuss the potential of CAR-T cell in combination with anti PD-1 therapy for treatment of CRC. Method: The review materials used in this paper were taken from journals found through PubMed then compiled systematically. Results and Discussion: Based on previous studies, high level of IFN-? and TNF-? secretions were found in Epithelial Cell Adhesion Molecule (EpCAM) tumor cells, showing that EpCAM-CAR-T cells have specific cytotoxic effect on target tumor cells. The average colorectal tumor volume in the EpCAM-CAR-T cell group were lower than the control group, indicating that EpCAM-CAR-T cells were able to inhibit both the formation and growth of tumor cells. On the other hand, administration of anti PD-1, nivolumab for metastasis CRC shows a durable responses and disease control, as well as long-term survival. Conclusion: The combination of EpCAM-CAR-Tcell immunotherapy with anti PD-1 nivolumab could be an effective potential novel treatment for CRC. Keywords: anti PD-1, CAR-T cell, colorectal cancer, immunotherapy
Pengaruh Radioterapi Terhadap Parameter Hasil Pemeriksaan Darah Lengkap Pasien Karsinoma Nasofaring di Rumah Sakit Pendidikan Universitas Hasanuddin Periode 2016-2018 imam hermansyah; Eddy Zulfikar; Aton Prasetya Sibala'; William Chandra Papendang; Ahmad Fachry Toaha; Yuyun Widaningsih
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 1 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.1 Edisi Maret - Juli
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i1.361

Abstract

ABSTRACT Itroduction: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in the head and neck areas. Recently, radiotherapy remain to be the treatment of choice for NPC, especially for the loco-regional type that hasn’t extend into distant metastasis. However, radiotherapy may cause side effect on the hematopoietic system, which has made complete blood tests mandatory for NPC patient that undergo radiotherapy treatment. Unfortunately, data regarding the effect of radiotherapy on complete blood test parameter of NPC patients are still very limited in Indonesia. Therefore, this study aims to analyse the effect of radiotherapy on the hematopoietic system in NPC patient based on the leukocyte count, hemoglobin concentration, and platelet count. Method: This study was an observational analytic study with cross sectional design using medical records of NPC patients that undergo full cycle of radiotherapy at the Teaching Hospital of Hasanuddin University in 2016-2018. The collected data analysed by using Friedman method. Results: Of the 41 patients included in this study, the mean significant difference on complete blood test parameter post-radiotherapy was only found in the leukocyte count (p<0,05) compared to the hemoglobin and platelet count variable (p>0,05). Discussion: Radiation on the bone marrow will cause a depression in the number of blood cells due to the destruction of hematopoietic stem cells and progenitor which are very sensitive to radiation. Based on the level of sensitivity to radiotherapy, leukocytes are the most radiosensitive, followed by platelets then erythrocytes. Conclusion: Radiotherapy has a significant effect on the changes of leukocyte count in patients with NPC. Keywords: Complete blood test, nasopharyngeal carcinoma, radiotherapy
Co-Authors Ahmad Fachry Toaha Aton Prasetya Sibala&#039; Eddy Zulfikar Eddy Zulfikar William Chandra Papendang Yuyun Widaningsih