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All Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Farmasi Indonesia
Nita Selifiana
Fakultas Farmasi, Universitas Bhakti Kencana, Bandung
Computer Science & IT Medicine & Pharmacology Social Sciences Other

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Upaya Peningkatan Imunitas Tubuh Masyarakat Kampung Rancasalak-Cimaung dengan Edukasi PHBS dan Pemanfaatan Toga Dadang Juanda; Muhamad Reza Pahlevi; Nita Selifiana; Ika Kurnia Sukmawati; Widhya Aligita
Warta Pengabdian Andalas Vol 31 No 3 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.3.620-627.2024

Abstract

Body immunity for a worker major role in providing optimal performance in their work. Good immunity can be obtained by implementing PHBS and consuming herbs which are known to increase immunity. This activity is carried out in order to improve the quality of health in order to improve the quality of people in carrying out their activities, especially work. Community service activities will be carried out on November 13, 2023 to November 20, 2023. Activities include promotional efforts such as providing education about Perilaku Hidup Bersih dan Sehat (PHBS) and medicinal plants to increase immunity, moreover providing tutorials on how to process instant granules from TOGA. The results of the pre & post-test scores provide an illustration that there is an increase in understanding of PHBS and TOGA. It is hoped that the information provided will have a positive impact on the health of the UMKM cracker and chips workers in Kampung Rancasalak.
Peran Ekstrak Kunyit dan Pegagan dalam Modifikasi Ekspresi Gen eNOS: Implikasi Terhadap Gangguan Ginjal pada Obesitas Agus Sulaeman; Eci Perayani; Soni Muhsinin; Nita Selifiana; Elis Susilawati; Marita Kaniawati; Aghnia Nurvianti Nafilah; Hendra Mahakam; Putra Putra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.763

Abstract

Obesity is a global health problem closely associated with endothelial dysfunction, oxidative stress, and renal impairment, where endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) levels serve as critical biomarkers for endothelial function. This study aimed to evaluate the effects of turmeric (Curcuma longa) extract, pegagan (Centella asiatica) extract, and their combination on body weight, organ index, fat index, blood biomarkers, and renal eNOS gene expression in obese rats. Male white rats were randomly divided into six groups: normal control, negative control (high-fat diet), positive control (orlistat 10.8 mg/kgBW), turmeric extract (200 mg/kgBW), pegagan extract (200 mg/kgBW), and a combination of turmeric–pegagan extracts (200:100 mg/kgBW). Treatments were administered for 60 days, and parameters assessed included body weight, organ index, fat index, blood biomarkers (ITT, creatinine, NO, elastin), and renal eNOS expression using PCR. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. The results demonstrated that the combination of turmeric and pegagan extracts significantly reduced body weight, liver, kidney, and heart indices, as well as visceral fat index, while improving blood biomarkers through the reduction of creatinine levels, along with an increase in NO serum approaching normal compared with the negative control group; the respective mean values were -10.14±0.57%, 5.52±0.73%, 1.23±0.21%, 0.64±0.06%, 1.35±0.05%, 0.33±0.06 mg/dL, dan 5.14±0.58 mmol/L. Renal eNOS expression exhibited an increasing trend in the combination group, although not statistically significant. In conclusion, the combination of turmeric and pegagan extracts exerts synergistic effects in improving endothelial dysfunction and renal impairment in obesity through lipid profile modulation, reduction of organ damage biomarkers, and enhancement of NO bioavailability.
Co-Authors Aghnia Nurvianti Nafilah Agus Sulaeman Dadang Juanda Eci Perayani Elis Susilawati Hendra Mahakam Ika Kurnia Sukmawati Marita Kaniawati Muhamad Reza Pahlevi Putra Putra Soni Muhsinin Widhya Aligita