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All Journal Manuju : Malahayati Nursing Journal JOURNAL OF Mother and Child Health Concerns
Yuli Peristiowati
Universitas STRADA Indonesia
Health Professions Nursing Public Health

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Analysis of potential drug interactions in pulmonary tuberculosis patients in the pediatric clinic Febria Listina; Yuli Peristiowati
THE JOURNAL OF Mother and Child Health  Concerns Vol. 4 No. 9 (2025): December Edition
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Persatuan Perawat Nasional Indonesia (PPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/mchc.v4i9.2065

Abstract

Background: Analysis of Potential Drug Interactions of Pulmonary Tuberculosis Patients at The Children’s Poly of Imanuel Wayhalim Hospital Bandar Lampung. Tuberculosis (TB) is an infectious disease caused by infection with the bacterium Mycobacterium tuberculosis (MTB). Treatment in tuberculosis patients is given Anti-Tuberculosis Drugs (OAT) consisting of isoniazid, rifampicin, pyrazinamide, ethambutol and streptomycin. Purpose: To analysis of potential drug interactions in pulmonary tuberculosis patients in the pediatric clinic. Method: This study is a non- experimental descriptive study (observational). Sampling using purposive sampling method. The data collection was retrospectively taken from the medical records of tuberculosis patients at the children's poly of Imanuel Wayhalim Hospital Bandar Lampung for the period October – December 2025. Results: The results of the study found that the characteristics of TB patients of the highest age were toddlers (0-5 years) as many as 35 patients (83.3%), the highest sex was male as many as 27 cases (64%), potential drug interactions contained in the therapy of TB pediatric patients were pharmacokinetic interactions in the metabolic phase of OAT and OAT as many as 2 cases (50%), pharmaco dynamic interactions of OAT and OAT as many as 2 cases (50%), pharmaco kinetic interactions in the metabolic phase of OAT and other drugs as many as 10 cases (45.5%), pharmacodynamic interactions of OAT and other drugs as many as 12 cases (54.5%). Based on the severity of OAT and OAT drug interactions, Major results were obtained as many as 2 cases (100%) and the severity of OAT drug interactions and other drugs obtained Moderate results as many as 8 cases (57%), Major as many as 6 cases (43%). Conclusion: Based on research, it can be concluded that anti- tuberculosis drugs that inter actalotarer if ampicin with isoniazid and triamcinolone and the most common type of drug interaction is pharmacokinetics in the metabolic phase. The severity of drug interactions that occur is highest in the moderate category.
Pengaruh Mobilisasi Dini dan Perawatan Luka Terhadap Penurunan Intensitas Nyeri dan Penyembuhan Luka Pasca Operasi Sectio Caesarea di RSU Setio Husodo Indah Almaidah; Rahmania Ambarika; Yuli Peristiowati
Malahayati Nursing Journal Vol 8, No 7 (2026): Volume 8 Nomor 7 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i7.25343

Abstract

ABSTRACT Cesarean section is a surgical procedure that often causes postoperative problems such as pain and impaired wound healing. Poorly managed pain can hinder early mobilization, daily activities, and delay the recovery process, while suboptimal wound healing may increase the risk of infection. Therefore, non-pharmacological interventions such as early mobilization and structured wound care are needed. This study aimed to analyze the effect of early mobilization and wound care on reducing pain intensity and accelerating wound healing in post-cesarean section patients at Setio Husodo General Hospital, Kisaran. This study used a pre-experimental design with a quasi-group pretest-posttest approach involving control and intervention groups. The population consisted of all post-cesarean section mothers totaling 137 individuals, with a sample of 102 respondents selected using purposive sampling technique. Data were analyzed using Paired Sample t-test and Independent Sample t-test. The results showed that early mobilization and wound care had a significant effect on reducing pain intensity and accelerating wound healing with a p-value 0.05. The intervention group showed faster pain reduction and better wound healing compared to the control group. Conclusion early mobilization and structured wound care are proven to be effective in reducing pain intensity and accelerating wound healing in post-cesarean section patients, and therefore should be optimally implemented in healthcare practice. Keywords: Early Mobilization, Wound Care, Pain Intensity, Wound Healing,   Cesarean Section.  ABSTRAK Operasi sectio caesarea merupakan tindakan pembedahan yang sering menimbulkan masalah pasca operasi berupa nyeri dan gangguan penyembuhan luka. Nyeri yang tidak tertangani dengan baik dapat menghambat mobilisasi, aktivitas sehari-hari, serta memperlambat proses pemulihan, sedangkan penyembuhan luka yang tidak optimal dapat meningkatkan risiko infeksi. Oleh karena itu, diperlukan intervensi non-farmakologis seperti mobilisasi dini dan perawatan luka yang terstruktur. Tujuan Penelitian: Penelitian ini bertujuan untuk menganalisis pengaruh mobilisasi dini dan perawatan luka terhadap penurunan intensitas nyeri dan percepatan penyembuhan luka pasca operasi sectio caesarea di RSU Setio Husodo Kisaran. Desain Penelitian: Penelitian ini menggunakan desain pra-eksperimental dengan rancangan quasi group pretest-posttest dengan kelompok kontrol dan intervensi. Populasi dalam penelitian ini adalah seluruh ibu post operasi sectio caesarea sebanyak 137 orang, dengan sampel sebanyak 102 responden yang diambil menggunakan teknik purposive sampling. Analisis data dilakukan menggunakan uji Paired Sample t-test dan Independent Sample t-test. Hasil penelitian menunjukkan bahwa terdapat pengaruh signifikan mobilisasi dini dan perawatan luka terhadap penurunan intensitas nyeri dan percepatan penyembuhan luka dengan nilai p-value 0,05. Kelompok intervensi menunjukkan penurunan nyeri yang lebih cepat dan penyembuhan luka yang lebih baik dibandingkan kelompok kontrol.  Kesimpulan: Mobilisasi dini dan perawatan luka yang dilakukan secara terstruktur dan sesuai standar terbukti efektif dalam menurunkan intensitas nyeri dan mempercepat penyembuhan luka pada pasien post operasi sectio caesarea, sehingga perlu diterapkan secara optimal dalam praktik pelayanan kesehatan. Kata Kunci: Mobilisasi Dini, Perawatan Luka, Intensitas Nyeri, Penyembuhan Luka, Sectio Caesarea.
Co-Authors Febria Listina Indah Almaidah Rahmania Ambarika