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All Journal Bali Dermatology Venereology and Aesthetic Journal Journal of Medicine and Health
Elvina Veronica
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potential Extract of Poinsettia (Euphorbia pulcherrima) as a sunscreen against UV exposure Elvina Veronica; Ni Kadek S Chrismayanti; Putu S Dampati
Journal of Medicine and Health Vol 3 No 1 (2021)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v3i1.2972

Abstract

Paparan sinar Ultraviolet (UV) dalam jangka waktu tertentu dapat menimbulkan eritema,sunburn, fotoalergi, serta memicu pembentukan Reactive Oxygen Species (ROS) yangmengakibatkan mutasi gen, penuaan dini, dan kanker kulit. Kanker kulit di Indonesia menempatiurutan ke-tiga kanker terbanyak setelah kanker rahim dan kanker payudara. Tabir surya digunakanuntuk melindungi kulit dari paparan sinar UV walaupun banyak tabir surya menggunakan bahankimia yang dapat menimbulkan kontak dermatitis dan alergi. Berbagai penelitian menunjukkanbahwa tanaman dengan kandungan senyawa yang memiliki aktivitas antioksidan dapatmelindungi kulit dari paparan sinar UV. Kastuba (Euphorbia pulcherrima) merupakan tanamanhias yang mengandung senyawa yang memiliki aktivitas antioksidan. Penulisan literature reviewini bertujuan untuk mengkaji potensi kastuba sebagai tabir surya terhadap sinar UV. Ekstrak daunkastuba berpotensi sebagai tabir surya terhadap paparan sinar UV karena kandungan antioksidanflavonoid dan lainnya yang bersifat fotoprotektor, menghambat pembentukan ROS sehinggamencegah terjadinya mutasi dan proses pembentukan kanker kulit. Antioksidan pada kastubamembantu menyembuhkan luka bakar dan menstimulasi pembentukan fibroblas sehingga mampumencegah photoaging dini akibat paparan sinar UV berlebih. Simpulan, ekstrak daun kastuba(Euphorbia Pulcherrima) berpotensi sebagai tabir surya terhadap paparan sinar UV. Kata kunci: Kastuba; Ultraviolet (UV); Antioksidan; Reactive Oxygen Species (ROS)
Systematic review of melasma treatments: advantages and disadvantages Sang Ayu Arta Suryantari; Ni Putu Tamara Bidari Sweta; Elvina Veronica; I Gusti Ngurah Bagus Rai Mulya Hartawan; Ni Luh Putu Ratih Vibriyanti Karna
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/dy28rh70

Abstract

Background: Melasma is acquired chronic hyperpigmentation mainly affecting women. The pathogenesis of melasma is uncertain, but it is predominantly related to ultraviolet (UV) exposure. Due to its chronic and relapsing nature, melasma is challenging to treat. The currently available treatment often has undesirable side effects and suboptimal results. The treatment principle includes protecting from UV radiation, inhibiting melanin synthesis, and increasing the pathway to remove melanin. Objectives: To define available treatments for melasma and determine advantages and disadvantages, including topical, oral and procedural. Method: Medline, Cochrane library and PubMed databases were searched for articles from January 2011 to June 2020. Only RCTs, comparative, prospective, retrospective and systematic reviews focusing on melasma treatments were extracted, analyzed and discussed. Results: We found 197 studies that met the inclusion and exclusion criteria, with 2314 participants included in this review. The treatments included topical, oral and procedural. In several studies, hydroquinone alone or combination remains the most effective treatment for melasma. Oral and topical tranexamic acid is a beneficial adjuvant treatment in refractory melasma with minimal adverse effects. Procedural treatments such as chemical peels, laser and light-based therapies, and microneedling have mixed and unpredictable results. Overall, the side effects tend to be mild and affect a few of the subjects. Conclusions: The current state of the evidence suggests that some treatments with multiple modalities have their respective advantages and disadvantages. The choice of treatment modality must be adjusted according to the type of melasma, such as its severity, extent and location. A better understanding of melasma through further research may improve the therapy options with the least adverse effects.
Co-Authors I Gusti Ngurah Bagus Rai Mulya Hartawan Ni Kadek S Chrismayanti Ni Luh Putu Ratih Vibriyanti Karna Ni Putu Tamara Bidari Sweta Putu S Dampati