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Increase of Fibroblast Cells in Wound Healing of Diabetes Mellitus Male Rats (Rattus Norvegicus) Using Aloin Ade Teti Vani; Cindy Arlita; Lismawati Lismawati; Nadia Purnama Dewi; Dessy Abdullah; Meta Zuliyanti Oktora
Oshada Vol. 1 No. 4 (2024): Oshada Journal - August
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/3fvt9h57

Abstract

The healing process wound on the skin diabetic experience slowdown because dysfunction fibroblasts. Aloins boost expression fibroblasts that can accelerating the process of wound healing in patients with Diabetes Mellitus (DM). Objective study that is for now effect enhancement cell fibroblasts in wound healing wound I t mouse male DM with aloe giving. Method study use principle true experimental with approach post-test serial only control group design. Treatment form wound cut on mice. Group study using 4 groups with a negative control in the form mouse healthy, positive control form DM mouse. group action 1 in the form of DM rats were given 1.25 mg/ kg BW aloin and treatment 2 was in the form of DM rats given 2.5 mg/ kg BW aloin. Expression fibroblasts calculated on day 7 and day 14. Analysis bivariate using the Friedman test continued with the Wilcoxon Post- Hoc test. Research results that are there is enhancement fibroblasts significant in the group treatment given with aloein a dose of 1.25 mg/ kg and a dose of 2.5 mg/ kg. The conclusion is that Aloin accelerates wound healing wound incision in DM rats with mechanism enhancement expression fibroblasts with minimum dose of 1.25 mg/ KgBB. Research suggestions that is examination of re- epithelialization and density Dermal collagen in wound healing wound I t DM rats given aloein in the study next.
Chances of Presbycusis in Minangkabau Elderly Patients with Type 2 Diabetes Mellitus Without Complications in Padang City Irwan Triansyah; Salsabila Putri Amril; Fredia Heppy; Ade Teti Vani; Nadia Purnama Dewi; Dessy Abdullah
Oshada Vol. 1 No. 3 (2024): Oshada Journal - June
Publisher : PT. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/4ty69f72

Abstract

Background: Presbycusis is a loss of hearing ability that occurs slowly with age. One of the risk factors that plays a role in the occurrence of presbycusis is diabetes mellitus. Diabetes mellitus is an extrinsic factor that affects cochlear blood flow and reduces nutrient transport through deoxygenation, resulting in secondary degeneration of the organ of corti and the auditory nerve. Aim: To assess the increase in the chance of presbycusis in elderly people with type 2 diabetes mellitus without complications in the Minangkabau tribe in Padang City. Method: This research is unpaired categorical analytical research with a case control design using primary data. Samples were selected using consecutive sampling technique. Data analysis used univariate and bivariate analysis using the Chi-Square test. Results: Presbycusis was most commonly found in the young elderly group, 16 people (84.2%), the gender of the presbycusis elderly was mostly female, 12 people (63.2%), the longest time diagnosed with diabetes mellitus, the most presbycusis elderly was ≥5 years, 13 people (68.4%), the Minangkabau tribe with the most presbycusis elderly is Jambak 5 people (26.3%). The highest audiometric description of elderly people was mild, 16 people (45.7%). The majority of elderly people experienced mild presbycusis, 10 people (30.3%). There is a significant increase in the chance of presbycusis in elderly people with type 2 diabetes mellitus without complications with p=0.015 and an OR calculation of 3.431. Conclusion: There was an increased chance of presbycusis in elderly people with type 2 diabetes mellitus without complications.