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All Journal Biology, Medicine, & Natural Product Chemistry Mosaic: Jurnal Pengabdian Kepada Masyarakat Al-Musthalah: Jurnal Riset dan Penelitian Multidisiplin
Astrid Ekklesia Saputri
Universitas Palangka Raya
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Gambaran Pengetahuan, Sikap, dan Motivasi Mengenai Donor Darah pada Kegiatan Hemoglobin AMSA-UPR Sintice Dhea Valerie; Nasywa Putri Rahmadina; Tarra Auliazar; Lauren Maretha; Estilia Ledyani; Qonita Sari Bustomi; Astrid Ekklesia Saputri; Nadiah Romadhona Putri; Nur Khalifah Putri Utami; Cereymo Ewaldo; Rian Ka Praja
Mosaic: Jurnal Pengabdian Kepada Masyarakat Vol 2, No 1 (2025): April 2025
Publisher : Academic Bright Collaboration

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61220/mosaic.v2i1.526

Abstract

Ketersediaan darah di Unit Donor Darah sangat bergantung pada partisipasi donor darah sukarela, di mana pengetahuan, sikap, dan motivasi menjadi faktor penting untuk menjamin ketersediaan yang cukup. Pengabdian ini bertujuan untuk menggambarkan tingkat pengetahuan, sikap, dan motivasi mengenai donor darah pada pendonor sukarela di SMAN 5 Palangka Raya pada tahun 2024. Desain kegiatan pengabdian ini bersifat deskriptif dengan pendekatan cross-sectional, melibatkan 51 peserta yang dipilih menggunakan teknik consecutive sampling. Data diperoleh melalui penyebaran kuesioner kepada peserta kegiatan dan dianalisis secara deskriptif untuk menggambarkan hasil pelaksanaan. Hasil menunjukkan bahwa donor darah sukarela didominasi oleh kelompok usia 14-15 tahun (45,1%), mayoritas berjenis kelamin perempuan (58,8%), dan merupakan siswa kelas 1 SMA (45,1%). Tingkat pengetahuan responden tentang donor darah tergolong baik (76,5%), dengan media elektronik sebagai sumber informasi utama. Sebanyak 96,1% responden menunjukkan sikap positif terhadap donor darah, dengan alasan utama menolong sesama (92,2%). Kesimpulan dari penulisan ini menunjukkan bahwa pendonor darah sukarela di SMAN 5 Palangka Raya memiliki tingkat pengetahuan, sikap, dan motivasi yang baik dalam mendukung kegiatan donor darah. Hal ini menunjukkan adanya potensi keberlanjutan dan partisipasi positif dalam kegiatan donor darah di kalangan remaja.
Tingkat Pengetahuan Perilaku Hidup Bersih Sehat (PHBS) Terhadap Kebersihan Pribadi Anak-Anak di Panti Asuhan Imanuel Rizqy Fajar Syaikhul Akmal; Lusi Ulina Simanungkalit; Raissa Amanda Lavefolia; Yohana Catherine Debyola Purba; Estilia Ledyani; Qonita Sari Bustomi; Astrid Ekklesia Saputri; Nadiah Romadhona Putri; Nur Khalifah Putri Utami; Cici Meyriliani Sensia; Rian Ka Praja
Mosaic: Jurnal Pengabdian Kepada Masyarakat Vol 2, No 1 (2025): April 2025
Publisher : Academic Bright Collaboration

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61220/mosaic.v2i1.530

Abstract

Permasalahan yang dihadapi dalam kegiatan pengabdian ini adalah masih kurangnya pemahaman sebagian siswa di Panti Asuhan Imanuel Palangka Raya mengenai Perilaku Hidup Bersih dan Sehat (PHBS), yang tercermin dari lemahnya kebiasaan menjaga kebersihan pribadi. Kegiatan ini bertujuan untuk mengetahui sekaligus meningkatkan pengetahuan dan praktik siswa tentang PHBS melalui pendekatan Participatory Action Research (PAR). Pendekatan ini melibatkan siswa dan pengurus panti secara aktif dalam proses identifikasi masalah, perencanaan, pelaksanaan aksi edukatif, hingga refleksi dan evaluasi. Sasaran kegiatan adalah seluruh siswa berusia 7–17 tahun yang berjumlah 30 orang. Instrumen pengumpulan data berupa tes tertulis pilihan ganda dan lembar observasi perilaku, yang dianalisis secara deskriptif dalam bentuk persentase. Hasil menunjukkan bahwa 90% siswa berada pada kategori pengetahuan baik, 10% cukup, dan 0% kurang. Temuan ini menunjukkan adanya peningkatan pemahaman siswa terhadap PHBS setelah intervensi. Untuk menjaga keberlanjutan perilaku hidup bersih dan sehat, disarankan pelaksanaan program edukasi lanjutan secara berkala serta penguatan peran Usaha Kesehatan Sekolah (UKS) atau program serupa di lingkungan panti asuhan.
Exploring the Gut-Brain Axis: Gut Microbiome Influence on Immune-Mediated Movement Disorderse-Mediated Movement Disorders Astrid Ekklesia Saputri; Muhammad Naufal Al-Firas; Muhammad Naufa Anwar; Rian Ka Praja
Al-Musthalah: Jurnal Riset dan Penelitian Multidisiplin Vol. 1 No. 1 (2024): April
Publisher : PT Syamilah Literasi Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In recent years, there has been substantial growth in research concerning the gut microbiome, largely due to its recognized role in influencing human physiology and immune function. The microbiome represents a complex ecosystem that interacts with infections, potentially shaping host responses along the gut-brain axis and impacting health outcomes. Imbalances in gut microbiota have been linked to various neurodegenerative diseases, including multiple sclerosis, Guillain-Barré syndrome, and autoimmune encephalitis. This bibliometric study aimed to deepen our understanding of the relationship between gut microbiota and immune-mediated movement disorders, addressing gaps in research knowledge and investigating underlying mechanisms. Through an analysis of research themes, countries, institutions, and publication trends, we utilized the Scopus database and VOSviewer software to conduct a comprehensive examination. Our findings, spanning the years 2015 to 2023, revealed that the United States and Germany were leading contributors to global research in this area. Furthermore, Parkinson’s disease emerged as a prominent topic within the context of movement disorders associated with gut microbiota dysbiosis. Overall, this bibliometric analysis highlights the evolving landscape of gut microbiome research, emphasizing the need for continued exploration to inform preventive strategies and enhance infection management worldwide.
Bioinformatics Analysis of Quercetin and Morin Bioactivity from Morinda citrifolia L. Targeting Streptococcus mutans Virulence Factors In Dental Caries Cases Astrid Ekklesia Saputri; Rian Ka Praja; Agnes Frethernety; Oktaviani Naulita Turnip; Ysrafil Ysrafil
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.535-553

Abstract

Dental caries remains one of the most neglected oral diseases, particularly among populations living far from healthcare services. Its pathogenesis is largely triggered by poor oral hygiene and the activity of Streptococcus mutans. The use of synthetic antimicrobial agents often leads to prolonged side effects and a higher risk of antibiotic resistance. As an alternative, Morinda citrifolia L. extract shows high potential due to its good public acceptance, minimal side effects, and proven in vitro efficacy in inhibiting S. mutans growth. This study aimed to investigate the bioactivity factors of S. mutans in relation to specific components of Morinda citrifolia L. as an alternative therapeutic agent for dental caries using a bioinformatics-based approach. A descriptive-exploratory bioinformatics method was employed using computational analysis. The bacterial FASTA sequence of Streptococcus mutans UA159 was retrieved from the National Center for Biotechnology Information (NCBI) database and analyzed using several software tools, including STITCH v5.0, VICMPred, VirulentPred, BepiPred v1.0, MHC I and MHC II BindingPred, and PSORTb v3.0. The analysis revealed notable interactions in bioactivity between S. mutans proteins and the phytocompounds quercetin and morin. Seven virulent proteins PknB, SMU_1806, SMU_1213c, SMU_922, SMU_906, SMU_525, and SMU_1078c, contribute to cellular process, metabolism, virulence factors, and information & storage. Five proteins were identified in the cytoplasmic membrane, one in cell wall, and also cytoplasm. Quercetin and morin demonstrated strong antibacterial potential against S. mutans through interactions with virulent proteins. PknB, SMU_906, and SMU_1078c stand out in epitope T cell analysis with high affinity, demonstrating the ability to provoke an adaptive immune system response. Location complexity of 5’-nucleotide enzyme targeted by strategic antimicrobials leads to bacterial mortality.
Co-Authors Agnes Frethernety Cereymo Ewaldo Cici Meyriliani Sensia Estilia Ledyani Lauren Maretha Lusi Ulina Simanungkalit Muhammad Naufa Anwar Muhammad Naufal Al-Firas Nadiah Romadhona Putri Nasywa Putri Rahmadina Nur Khalifah Putri Utami Oktaviani Naulita Turnip Qonita Sari Bustomi Raissa Amanda Lavefolia Rian Ka Praja Rizqy Fajar Syaikhul Akmal Sintice Dhea Valerie Tarra Auliazar Yohana Catherine Debyola Purba Ysrafil, Ysrafil