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All Journal Indonesian Journal of Global Health research Synthesis Global Health Journal
Romauli Lumbantobing
Universitas Kristen Indonesia
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Relationship between Knowledge and Attitude with Tuberculosis Prevention Efforts in Preclinical Students Romauli Lumbantobing; Lamtiur Oktavia; Mulyadi Djojosaputro
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6408

Abstract

Tuberculosis (TB) is an infectious disease that can be transmitted, caused by the bacteria Mycobacterium tuberculosis. It is still one of the health problems for national and global communities. This disease can cause disability and even death for sufferers, so it becomes a focus in the goals of sustainable health development. Objective to analyze the relationship between knowledge and attitudes with tuberculosis prevention efforts in preclinical students of the 2022 intake at the Faculty of Medicine, Indonesian Christian University. Method: This study used analytical research with a cross-sectional approach. The number of samples used was 115 respondents, which were taken using the total sampling technique. Based on the research results, 95.6% of preclinical students of the 2022 batch at the UKI Medical Faculty have good knowledge about tuberculosis and 89.6% of students have good attitudes towards efforts to prevent tuberculosis. In the results of the bivariate analysis using the chi-square test, the relationship between knowledge and efforts to prevent tuberculosis was obtained with a p-value of 0.000 (<0.05). In the analysis of the relationship between attitudes and efforts to prevent tuberculosis, a p-value of 0.009 (<0.05) was obtained. From the results of the chi-square test, there was a significant relationship between knowledge and attitudes with efforts to prevent tuberculosis in preclinical students of the 2022 batch at the Faculty of Medicine, Indonesian Christian University. Conclusion: Good knowledge allows students to understand how TB is transmitted, its symptoms, and control strategies. Meanwhile, a positive attitude will form motivation and concern to actively participate in prevention. Therefore, improving these two aspects is an important key in strengthening TB prevention measures among preclinical students.
COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF OLD AND NEW TB DRUGS IN THE TREATMENT OF PULMONARY TUBERCULOSIS Romauli Lumbantobing; Linggom Kurniaty; Welly Salutondok; Tiroy Sari B. Simanjuntak
SYNTHESIS Global Health Journal Volume 3, Issue 2, 2025
Publisher : SYNTIFIC

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61543/syn.v3i2.148

Abstract

Background. The availability of effective drug regimens of Pulmonary tuberculosis (TB) poses a global health challenge. Traditional first-line therapies-isoniazid, rifampicin, pyrazinamide, and ethambutol-remain the cornerstone of TB management due to their accessibility and documented cure rates exceeding 85%. Nevertheless, limitations such as variable drug metabolism, patient non-adherence, and the emergence of multidrug-resistant strains have prompted evaluation of newer treatment combinations to optimize efficacy, safety, and duration. The purpose was to compare the effectiveness of older first-line tuberculosis (TB) drug regimens with newer therapeutic regimens in the treatment of pulmonary tuberculosis. Research Method. This narrative review synthesizes findings from five peer-reviewed studies comparing the effectiveness and safety profiles of conventional and novel TB drug regimens. The review focused on regimen composition, treatment duration, bacteriological clearance, hepatotoxicity, and patient adherence outcomes. Findings. The inclusion of pyrazinamide in six-month regimens significantly accelerated bacterial clearance without increasing hepatic toxicity compared to traditional nine-month isoniazid–rifampicin regimens. Additionally, shorter rifampin-based regimens for latent TB demonstrated higher treatment completion rates and fewer adverse effects than isoniazid monotherapy. Emerging regimens, such as fluoroquinolone-based HRM therapies and the novel BPaL combination (bedaquiline, pretomanid, and linezolid), yielded comparable or improved outcomes, with BPaL achieving success rates up to 93% in drug-resistant TB cases. Conclusion. Current evidence supports the strategic adaptation of TB therapy to balance efficacy, tolerability, and treatment duration. Incorporating newer drug combinations, particularly for drug-resistant TB, enhances adherence and clinical outcomes, underscoring the need for individualized treatment protocols aligned with evolving resistance patterns and patient profiles.
Co-Authors Lamtiur Oktavia Linggom Kurniaty Mulyadi Djojosaputro Tiroy Sari B. Simanjuntak Welly Salutondok