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All Journal Indonesian Journal of Global Health research
Kristo Alberto Nababan
Adam Malik General Hospital
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Case Report: Suspected Thiamphenicol-Induced Stevens-Johnshon Syndrome-Toxic Epidermal Necrolisis Overlap in A Child – Diagnosis and Management Ika Diamanda Apriano; Deryne Anggia Paramita; Kristo Alberto Nababan
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6523

Abstract

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare delayed-type hypersensitivity reactions characterized by detachment of the epidermis and mucous membranes, along with skin necrosis. While these conditions are rare in children, they are most commonly caused by antibiotics, antiepileptic drugs, and antipyretic drugs. This case report aims to highlight thiamphenicol as a rare and potentially overlooked cause of SJS/TEN in pediatric patients. A 14-year-old girl who developed painful red patches accompanied by fluid-filled blisters on almost her entire body which appeared five days after taking the antibiotic thiamphenicol. The patient also experienced red, watery eyes; blisters on the lips and oral cavity; involvement of the nipples; and was unable to swallow due to severe pain in the mouth and throat. The patient was diagnosed with SJS-TEN overlap, and showed a good response to systemic corticosteroids (methilprednisolone) and supportive therapy. Her overall prognosis was favorable, with a Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) score of 1. The management of SJS/TEN involves a multidisciplinary specialist approach, immediate withdrawal of the suspected drug, administration of corticosteroids, and comprehensive supportive care.
Marked Clinical Improvement of Psoriasis Vulgaris with Methotrexate: A Case Report with 75% PASI Reduction Widya Gabriella Manurung; Kristo Alberto Nababan
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6859

Abstract

Psoriasis is an immune-mediated chronic, recurrent, systemic inflammatory disease induced by the combination of hereditary and environmental factors. The etiology of this disease involves many factors, including genetics, immunology, and the environment. Clinically, psoriasis vulgaris is characterized by the presence of reddish plaques with thick, symmetrically distributed squama mainly in the predilection areas. In moderate to severe cases, systemic therapy such as phototherapy, systemic anti-inflammatory agents, or biologic treatments is required, with topical therapy serving as an adjunct. Methotrexate is one of the effective systemic treatment options for severe psoriasis, either as monotherapy or in combination regimens. This case report aims to demonstrate the clinical efficacy of methotrexate in the management of moderate-to-severe psoriasis vulgaris. We report a case of a 37-year-old male presenting with scaly reddish skin thickening accompanied by itching all over the body. Clinical and histopathological examination confirmed the diagnosis of Psoriasis Vulgaris and treated with methotrexate. After a period of regular weekly methotrexate administration and monitoring, the patient achieved a 75% reduction in the Psoriasis Area and Severity Index (PASI), indicating significant therapeutic response. This case highlights the efficacy of methotrexate as a cost-effective and accessible treatment option for achieving substantial disease control in psoriasis vulgaris.
Co-Authors Deryne Anggia Paramita Ika Diamanda Apriano Widya Gabriella Manurung