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All Journal AcTion: Aceh Nutrition Journal
Adriyan Pramono
Department of Nutrition Science, Faculty of Medicine, Diponegoro University
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Correlation of lipid profile, glucose, and body composition on insulin resistance in overweight and obese subjects Fatmayanti Nawai; Ahmad Syauqy; Adriyan Pramono
AcTion: Aceh Nutrition Journal Vol 9, No 1 (2024): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v9i1.1571

Abstract

Indonesia has the highest prevalence of obesity in the Asia-Pacific region. Insulin resistance is a form of obesity that causes damage to the liver, heart, and pancreatic tissue as we age. This study aimed to determine the correlation among lipid profiles, glucose levels, body composition, and insulin resistance. Methods: This study used a pre-experimental design and was conducted at the Gorontalo Ministry of Health Polytechnic in February 2023 on 31 obese people whose venous blood was collected for examination of insulin resistance variables. Data were collected by purposive sampling with data analysis using Pearson Correlation and Spearman Rank statistical tests at a 95% confidence interval (CI). Results: Insulin resistance status based on sex, using the TyG index, was dominated by women (55%) among the 20 people who experienced insulin resistance. Men are more likely to be aged <30 years than women, according to the HOMA-IR index. The Pearson triglyceride test value (p= 0,000, r= 0,974) shows that the relationship between triglycerides and the TyG index was very strong, whereas when the HOMA-IR index was used, fasting insulin (p= 0,000, r= 0,985) had a very strong relationship. In conclusion, lipid profile (triglycerides, total cholesterol, LDL), fasting glucose, fasting insulin, and visceral fat percentage correlated with insulin resistance.
Effectiveness of synbiotic red dragon fruit yogurt on glucose and oxidative stress in metabolic syndrome rats Ninik Rustanti; Nyoman Putri Ari Armelinda; Kharisma Dwi Febriandina; Martha Ardiaria; Ayu Rahadiyanti; Mursid Tri Susilo; Adriyan Pramono
AcTion: Aceh Nutrition Journal Vol 10, No 1 (2025): March
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i1.2231

Abstract

Metabolic syndrome is still a global health problem, especially in Indonesia. Oxidative stress is related to metabolic syndrome because it is triggered by hyperglycemia. Synbiotic yogurt containing the whole red dragon fruit has antioxidant and synbiotic potential. This study aimed to determine the effect of synbiotic yogurt with whole red dragon fruit on fasting blood glucose (FBG) and malondialdehyde (MDA) levels in rats with metabolic syndrome. The design of this study was true-experimental, with a pre-post test and randomized control group design. A total of 24 male Sprague Dawley rats were divided into four groups (K-, K+, P1, P2). Groups K+, P1, and P2 were fed a high-fat, high-fructose diet (HFHFD) for 2 weeks. Groups P1 and P2 were administered synbiotic yogurt intervention of 0,009 mL/gBB/day and 0,018 mL/gBB/day, respectively, for 4 weeks. GOD-PAP method for FBG analysis and TBARS method for MDA analysis.  Data were analyzed using the paired t-test and One-Way ANOVA test. The P1 and P2 groups experienced a significant decrease in FBG levels by 63,45% and 76,07%, respectively (p<0,001), and a significant decrease in MDA by 26,1% and 37,2%, respectively (p<0,001). In conclusion, the administration of synbiotic yogurt at 0,018 mL/gBB/day (200 mL/day for humans) for four weeks was effective in reducing FBG and MDA levels.
Co-Authors Ahmad Syauqy Ayu Rahadiyanti Fatmayanti Nawai Kharisma Dwi Febriandina Martha Ardiaria Mursid Tri Susilo Ninik Rustanti Nyoman Putri Ari Armelinda