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Enkapsulasi Kurkumin dalam Matriks Beads Kitosan-Karaginan yang Tertaut-Silang dengan Glutaraldehida menggunakan Asam Laurat sebagai Pengemulsi Zhilal Shadiq; Muhamad Sofi Ardani; Nur Indah Wardani; Annisa Yuliana Angeline; Sari Sekar Ningrum
Sinteza Vol. 5 No. 2 (2025): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v5i2.30137

Abstract

Curcumin (diferuloylmethane), the primary bioactive compound in turmeric (Curcuma longa), is a natural polyphenol with proven pharmacological properties. Its safety and biodegradability, along with multifunctional health benefits, have been well-documented. However, curcumin exhibits poor water solubility. Consequently, curcumin shows low systemic bioavailability and rapid urinary excretion. A carrier matrix is essential to improve bioavailability and prolong systemic retention of curcumin, and one of carrier matrix that can be utilized is a bead matrix. In this study, bead matrices were prepared by combining a chitosan solution with lauric acid and carrageenan solutions and then dropping the mixture into a sodium hydroxide solution, which acts as an ionic neutralizing agent during bead formation. The encapsulation process was conducted by immersing the formed bead matrices in curcumin and glutaraldehyde solutions to facilitate crosslinking reactions with chitosan. The resulting bead matrices were analyzed using FT-IR spectroscopy to determine the interactions and bonds formed between the materials used. The results indicated that the encapsulation efficiency of curcumin was influenced by the concentrations of chitosan and lauric acid, with higher concentrations of both components leading to increased encapsulation efficiency.
Performance Analysis of the Unsignalized Nusantara Cilacap Three-Way Intersection Based on the 2023 Indonesian Road Capacity Guidelines Muhamad Sofi Ardani; Nur Indah Wardani; Annisa Yuliana Angeline; Sari Sekar Ningrum; Zhilal Shadiq
Journal of Social Research Vol. 5 No. 5 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i5.3138

Abstract

The increase in traffic volume, especially during long holidays coinciding with Eid al-Adha, can affect intersection performance and potentially cause issues such as changes in intersection capacity, degree of saturation, and traffic delays. Therefore, an analysis of intersection performance is necessary to evaluate the level of service at the Nusantara Three-Way Intersection in Cilacap. This study aims to calculate the intersection capacity, degree of saturation, traffic delay, and determine the level of service of the Nusantara Three-Way Intersection due to increased traffic volume. This research uses a quantitative approach based on primary and secondary data. The analysis was conducted according to the provisions of the Indonesian Road Capacity Guidelines (PKJI) 2023. The results show that the peak traffic volume occurred on Thursday, 5 June 2025, at 16:00– 17:00 WIB with a value of 886.40 PCU/hour (SMP/hour). The intersection capacity was 2,414.886 PCU/hour, with a degree of saturation of 0.367 and an average delay of 4.799 seconds per vehicle. The performance of the Nusantara Three-Way Intersection can be categorized as good, indicating that the level of service is still optimal and no additional lanes or traffic management measures are required