Article Per Year (5 Year)
p-Index From 2020 - 2025
0.835
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASI GALENIKA Proceeding of Mulawarman Pharmaceuticals Conferences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Sri Gustini Husein
Sekolah Tinggi Farmasi Indonesia, Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Synthesis N1-Tersier-Butilteobromin from Teobromin and Tersier-Butylbromides Husein, Sri Gustini; Zainuddin, Achmad; Hoeruman, Sani
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.687 KB) | DOI: 10.15416/ijpst.v5i3.17931

Abstract

Xantine derivatives are known to have some pharmacological activity, such as a bronchodilator. The substitution on atoms N1 xantine can improve the activity and selectivity as a tracheaspasm. The purpose of this research was to investigate the influence of concentration sodium hydroxide in sodium acetate as solvent used on the production yield of N1-tert-butilteobromin. The result of the synthesis was isolated using chloroform and purified with the preparative thin layer chromatography. The molecule structure of N1-tert-butilteobromin was confirmed using ultraviolet and infrared spectrophotometry. The result showed that sodium hydroxide concentration could effect the results of yield. The yields of 4%, 8%, and 12% sodium hydroxide concentration were 3.7% (0.074 g), 7.2% (0.144 g), and 1.3% (0.026 g), respectively.Keywords: N1-tert-butylteobromin, sodium hydroxide, tert-butylbromide, theobromine
Synthesis N1-Tersier-Butilteobromin from Teobromin and Tersier-Butylbromides Sri Gustini Husein; Achmad Zainuddin; Sani Hoeruman
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.687 KB) | DOI: 10.24198/ijpst.v5i3.17931

Abstract

Xantine derivatives are known to have some pharmacological activity, such as a bronchodilator. The substitution on atoms N1 xantine can improve the activity and selectivity as a tracheaspasm. The purpose of this research was to investigate the influence of concentration sodium hydroxide in sodium acetate as solvent used on the production yield of N1-tert-butilteobromin. The result of the synthesis was isolated using chloroform and purified with the preparative thin layer chromatography. The molecule structure of N1-tert-butilteobromin was confirmed using ultraviolet and infrared spectrophotometry. The result showed that sodium hydroxide concentration could effect the results of yield. The yields of 4%, 8%, and 12% sodium hydroxide concentration were 3.7% (0.074 g), 7.2% (0.144 g), and 1.3% (0.026 g), respectively.Keywords: N1-tert-butylteobromin, sodium hydroxide, tert-butylbromide, theobromine
Co-Authors Achmad Zainuddin Achmad Zainuddin Achmad Zainuddin Hoeruman, Sani Melvia Sundalian Nurdianti Nurdianti Nurul Husna Rozalia Putri Neno Ramdhani Sani Hoeruman Winingsih, Wiwin Wiwin Winingsih