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All Journal Farmaka Jurnal Ilmiah Kesehatan (JIKA)
KUSUMAWULAN, CAHYA KHAIRANI
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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REVIEW ARTICLE: UJI EFEKTIVITAS IN VIVO DAN IN VITRO ANTI-AGING PADA SEDIAAN KOSMETIK SHIBA, KAMILA; NURSIFA, HARITSA; KUSUMAWULAN, CAHYA KHAIRANI; SOPYAN, IYAN
Farmaka Vol 20, No 3 (2022): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i3.38775

Abstract

Penuaan terjadi secara alamiah pada manusia yang ditandai dengan munculnya keriput dan hiperpigmentasi.  Penuaan menjadi hal yang mendapat perhatian lebih oleh kaum wanita pada umumnya karena mempengaruhi penampilan. Banyak tanaman herbal maupun senyawa sintetis yang ditujukan sebagai agen anti penuaan. Bahan aktif tersebut diformulasikan menjadi bentuk sediaan kosmetik untuk memudahkan penggunaan pada konsumen dan mencapai efek yang maksimum. Dalam pembuktiannya, dibutuhkan pengujian yang komprehensif. Pengujiaan ini dapat berupa metode pengujian in vivo dan in vitro. Adapun penelitian ini dilakukan dengan metode article review dan didapatkan jurnal dari literature online jurnal lokal dan jurnal internasional yaitu pencarian secara elektronik dengan kata kunci efektivitas anti-aging, in vitro, in vivo, anti-aging dan sediaan kosmetik pada situs web yaitu Google Scholar. Hasil studi article review didapatkan bahwa beberapa metode yang digunakan adalah metode DPPH, kultur fibroblast dermal manusia, uji pada tikus, dan uji klinis pada manusia.Kata Kunci: Efektivitas anti-aging, in vitro, in vivo, anti-aging dan sediaan kosmetik 
Optimization of Cream Base and Hedonic Evaluation of Telon Cream with Variations in Essential Oil Composition Marissa, Zahra; Mita, Soraya Ratnawulan; Kusumawulan, Cahya Khairani
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1370

Abstract

Telon cream was developed as an alternative to traditional telon oil for infants to lower the risk of skin irritation from high essential-oil content while retaining its characteristic warming effect. This study optimized the cream base using the Simplex Lattice Design (SLD) and evaluated the effect of different essential-oil compositions on physical stability and sensory acceptance, focusing on the warming sensation. The base was optimized by varying the ratio of Olivem® 1000 and Flocare™ SK 425 to achieve suitable viscosity, spreadability, and adhesiveness. The optimized base was used to prepare four telon-cream formulas containing cajuput, fennel, ginger, and lavender oils. Stability was assessed by organoleptic observation, pH, viscosity, and spreadability under three storage conditions for four weeks. A hedonic test with 30 caregivers evaluated color, texture, aroma, and warming sensation using a 5-point liking scale. The optimal base ratio (Olivem® 1000:Flocare™ SK 425 = 4:1) yielded a desirability value of 1,0. All formulas met pH (5,9–6,1), viscosity (38,000–46,000 mPa·s), and spreadability (5,0–5,4 cm) requirements and remained stable. Hedonic testing showed no significant differences in color (p-value = 0,939) or texture (p-value = 0,665); aroma showed a borderline difference (p-value = 0,060), whereas the warming sensation differed significantly (p-value = 0,010). Formula F4 (cajuput 0,4%, fennel 0,4%, ginger 0,1%, lavender 0,1%) achieved the highest warming-sensation score with a favorable aroma. The optimized telon cream demonstrated good stability and was well accepted by users. The warming sensation emerged as a key attribute influencing consumer preference for telon creams.
Co-Authors Iyan Sopyan Marissa, Zahra NURSIFA, HARITSA SHIBA, KAMILA SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN