Background: Determining parental resilience in children with cancer is essential to ensuring parents’ involvement in caring for children in hospitals. Existing quantitative research evaluates factors influencing resilience in mothers but has not fully explored the determinants of resilience in parents of children with cancer. Studying parents more broadly is essential, as contemporary caregiving roles increasingly involve both mothers and fathers, offering a more comprehensive understanding of family dynamics.Purpose: This study aimed to analyze the determinants of parental resilience in children with cancer.Methods: Correlational research with a cross-sectional design was conducted in the pediatric ward of a tertiary hospital in Indonesia. A total of 102 parents of children with cancer were recruited using consecutive sampling. Data were collected using a demographic questionnaire, the 10-item Connor Davidson Resilience Scale (10-item CDRC), the Hert Hope Index (HHI), the International Personality Item Pool – Big Five Factor Markers 50 (IPIP-BFM-50), Parenting Stress Index (PSI), and the Survey of Family Environment (SFE). Quantitative data were analyzed using path analysis.Results: The results showed that the mean (SD) of the resilience score was 27.20 (5.79), personality 102.44 (19.11), hope 24.80 (6.04), parenting stress 39.22 (10.15), coping 39.84 (9.81), and family environment 84.57 (21.87). Resilience was directly influenced by hope (p=0.000), family environment (p=0.001), and coping (p=0.051). Personality indirectly influenced resilience (p=0.004). Path analysis revealed a Chi-square value of 0.000, a Root Mean Squared Estimate of Approximation (RMSEA) of 0.286, and values for the Normed Fit Index (NFI), Comparative Fit Index (CFI), Incremental Fit Index (IFI), and Goodness-of-Fit Index (GFI) were nearly close to 1, indicating the model had a nearly good fit.Conclusion: Parental resilience was determined by hope, family environment, and coping. Strengthening these factors can enhance resilience and support better outcomes for families and children with cancer.