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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Purnadiputra, Akbar
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Length of Cervix as Predictors of Premature Delivery during the Covid-19 Pandemic at Cipto Mangunkusumo General Hospital Djusad, Suskhan; Surya, Ilham Utama; Purnadiputra, Akbar; Pribadi, Muhamad Ichsan; Wicaksono, Muhammad Adhitya
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 1 January 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i1.1743

Abstract

Abstract Objective: The percentage of neonatal death continues to increase on a yearly basis, in which prematurity is the main cause of mortality. This study determines the descriptive outcomes between neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLT), and cervical length as predictors of preterm birth. Methods: A retrospective analytical study is conducted using medical records from Dr. Cipto Mangunkusumo National General Hospital. The subjects of this study includes pregnant women diagnosed with preterm delivery in Dr. Cipto Mangunkusumo National General Hospital from April 2020 to June 2021. Data on neutrophil-lymphocyte and platelet-lymphocyte ratios were obtained from a complete blood test during admission. Cervical length is measured using transvaginal ultrasound. The three variables are compared to the control group, which consists of pregnant women with full term delivery. Results: This study conducted a study with a total of 81 subjects with preterm delivery and 92 subjects with full term delivery. There were no significant difference in neutrophil-lymphocyte and platelet-lymphocyte ratios between preterm and a-term delivery (p=0.795 and p=0.475). Cervical length was significantly longer in preterm compared to full term delivery (24,50 vs 3,15 mm; p = 0,031). The neck cervical length of several participants was not assessed. Cervical length in preterm delivery obtained only 21 patients and data from 10 subjects from the full term group. Conclusion: The ratio of neutrophil-lymphocyte and platelet-lymphocyte cannot be used as predictors of preterm birth in all pregnant women. To reduce bias in this research, studies with prospective study design with a specified subject criteria are needed. Keywords: cervical length, neutrophil-lymphocyte ratio, platelet lymphocyte ratio, premature delivery
Inflammatory Marker and their Association with COVID-19 Severity in Pregnant Women Lisnawati, Yuyun; Purnadiputra, Akbar; Widyakusuma, Lucky Savitry; Pudyastuti, Sri; Sari, Amanda Mustika
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2686

Abstract

Abstract : Objective: To analyze the correlation between blood markers; C-Reactive Protein (CRP), D-Dimer, Neutrophil-to-Lymphocyte Ratio (NLR) and the severity of COVID-19 in pregnant women during the 2020 pandemic at Persahabatan Hospital, Jakarta. Method :This cross-sectional study was conducted at Persahabatan Hospital, a National Respiratory Referral Center in Jakarta. A total of 525 pregnant women with confirmed COVID-19 who met the inclusion criteria were included in the study. Laboratory markers, including CRP, D-Dimer, and NLR, were analyzed and categorized as normal or elevated. Data were analyzed using the Chi-square test, and correlations were evaluated using Spearman’s rank correlation coefficient. Result :The results showed that elevated biomarkers were significantly correlated with increased disease severity. CRP (>10 mg/L), D-Dimer (>3333 mg/L), and NLR (?5.8) were all associated with moderate to severe disease. All biomarkers demonstrated a significant correlation with disease severity (p < 0.005). Conclusion: Elevated CRP, D-Dimer, and NLR levels are associated with increased disease severity in pregnant women with COVID-19, suggesting their potential role as practical indicators for disease severity assessment. Keywords : Covid 19, CRP, D-Dimer, NLR, Pregnant.
Co-Authors Djusad, Suskhan Lisnawati, Yuyun Pribadi, Muhamad Ichsan Sari, Amanda Mustika Sri Pudyastuti Surya, Ilham Utama Wicaksono, Muhammad Adhitya Widyakusuma, Lucky Savitry