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All Journal Jurnal Ilmiah Farmasi Jurnal Penelitian Hasil Hutan
M. Ikhwan Rizki
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Agriculture, Biological Sciences & Forestry Decision Sciences, Operations Research & Management Materials Science & Nanotechnology Medicine & Pharmacology

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Determination of specific and non-specific parameters of saluang belum (Luvunga sarmentosa (Blume) Kurz.) root extract and quantification of its total flavonoid content Dina Fadhila Zahra; M. Ikhwan Rizki; Wathan, Nashrul
Jurnal Ilmiah Farmasi Vol. 21 No. 1 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss1.art7

Abstract

Background: Saluang belum (Luvunga sarmentosa (Blume) Kurz.) is an endemic plant native to the Kalimantan region. The Dayak people traditionally consume a decoction of L. sarmentosa root to improve stamina. Previous research has confirmed that the roots of L. sarmentosa possess antioxidant properties.Objective: This study aims to determine the characterization values of both specific and nonspecific parameters of the ethanol extract from L. sarmentosa roots, as well as to assess the total flavonoid content.Method: The research samples were collected from Timpah Village, Central Kalimantan. The methods for standardization employed the general standard parameters for Indonesian Herbal Extracts and the Pharmacopoeia. Specific parameters include the characteristics of the extract, phytochemical screening, and thin-layer chromatography profiles, while nonspecific parameters consist of determining water content, total ash, acid-insoluble ash content, and heavy metal contaminants (Pb, Cd, and Hg). The total flavonoid content was determined using a colorimetric method with AlCl₃ and quercetin as the standard.Results: The extract was characterized as a thick, yellowish-brown substance with a strong, distinct odor and a bitter taste. It contains alkaloids, flavonoids, tannins, terpenoids, and steroids. The TLC profile revealed four distinct spots using a non-polar eluent and six spots with a polar eluent. The extract yield was 8.57%, with an average water content of 2.43±0.15%, total ash content of 1.50%, and acid-insoluble ash content of 1.00±0.87%. Heavy metal contamination levels were determined as follows: Pb < 0.001 mg/kg, Cd 0.446 mg/kg, and Hg 2.077 mg/kg. The total flavonoid content of the extract was quantified at 6.9147 ± 0.0083 mg QE/g.Conclusion: All specific and non-specific parameters of the extract meet the requirements except for the heavy metal contaminants of Hg and Cd, which are still within the threshold limits set by BPOM. Meanwhile, the total flavonoid content measured was 6.9147 ± 0.0083 mg QE/g.
PENGARUH JENIS PELARUT DAN METODE EKSTRAKSI TERHADAP AKTIVITAS ANTIBAKTERI DAN PENGHAMBATAN RADIKAL BEBAS EKSTRAK KULIT KAYU BANGKAL (Nauclea subdita) Nazarni Rahmi; Rais Salim; Miyono; M. Ikhwan Rizki
Jurnal Penelitian Hasil Hutan Vol. 39 No. 1 (2021): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2021.39.1.13-26

Abstract

Bangkal bark is one of the plant materials widely used by local people of South Borneo for medicine and beautycare. The limited research explores the extraction process and biological activity of bangkal bark for this use, especiallyfor acne treatment. This study was conducted to determine the difference of extraction methods and solvent polarity tophytochemical contents, antibacterial and radical scavenging activities of bangkal bark extracts. Bangkal bark wasextracted by maceration, percolation and soxhletation methods with various solvents, namely water, 96% ethanol, 70%ethanol and ethyl acetate. Total phenolic content by Folin ciocalteu, total flavonoids with AlCl3, and total tannins withvanillin were determined. Free radicals scavenging activity was determined with DPPH free radicals and antibacterialwith agar diffusion method. Soxhlet method with 96% ethanol solvent showed the highest phenolic content about81.12±1.66 mg/gr GAE. The highest flavonoid content was found on the percolation method with ethyl acetateabout 24.24± 0.057 mg/gr QE. Total tannin content was found on percolation methods with 96% ethanol about36.92±0.81 mg/gr CE. All of 70% ethanol extract showed high inhibitory strength of DPPH radical above 87%at a 1 mg/ml concentration. Antibacterial activity in the extract showed that all methods and solvents had inhibitoryproperties against P. acne with various inhibitory zones. In contrast, only ethyl acetate and water extracts were able toinhibit P. acne and S. aureus both.
Co-Authors Dina Fadhila Zahra Miyono Nashrul Wathan Nazarni Rahmi Rais Salim