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All Journal Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) International Journal of Health and Pharmaceutical (IJHP)
Aprilyani, Anggi
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Humanities Education Health Professions Nursing Public Health Social Sciences

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Uji Ekstrak Buah Pala (Myrisca Fragnant Houtt) Terhadap Penurunan Kadar Glukosa dan Histopatologi Jaringan Pankreas Tikus Yang Diabetes Melitus Lisa, Elizabeth; Suwarno, Suwarno; Aprilyani, Anggi
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.767

Abstract

Penelitian ini bertujuan untuk mengevaluasi efektivitas ekstrak buah pala (Myristica fragrans Houtt) dalam menurunkan kadar glukosa dan memperbaiki kondisi histopatologi jaringan pankreas pada tikus diabetes. Diabetes melitus diinduksi dengan pemberian aloksan, dan tikus dibagi menjadi beberapa kelompok: kelompok kontrol, kelompok diabetes, dan kelompok perlakuan yang menerima berbagai dosis ekstrak buah pala. Kadar glukosa darah diukur untuk menilai efek antidiabetik, sedangkan pemeriksaan histopatologi jaringan pankreas dilakukan dengan pewarnaan hematoksilin dan eosin. Hasil penelitian menunjukkan bahwa pemberian ekstrak buah pala secara signifikan menurunkan kadar glukosa darah dan memperbaiki tampilan histopatologi pankreas dengan mengurangi kerusakan sel dan memperbaiki struktur jaringan. Temuan ini menunjukkan bahwa ekstrak buah pala berpotensi sebagai agen terapeutik untuk mengelola diabetes melitus dan komplikasinya.
Testing The Effectiveness Of Cinnamon (Cinnamomum Burmannii Blume) Ethanol Extract Against Staphylococcus Epidermidis Bacteria Lewinssky, Thania; Aprilyani, Anggi
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 3 (2025): August 2025 (Indonesia - Malaysia)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i3.432

Abstract

Skin infections caused by Staphylococcus epidermidis are a growing global health concern, exacerbated by increasing antibiotic resistance. This study aimed to evaluate the antibacterial activity of cinnamon (Cinnamomum burmannii Blume) ethanol extract as a natural alternative. A true experimental design with a post-test only control group was used. The population consisted of Staphylococcus epidermidis bacteria, and a total of 25 samples were assigned to five groups, including three extract concentrations (25%, 50%, and 75%), a clindamycin positive control, and a DMSO negative control. Antibacterial activity was tested using the disk diffusion method, and data were analyzed with Kruskal-Wallis and Mann-Whitney tests. The results showed that cinnamon extract effectively inhibited bacterial growth, with the 75% concentration producing the largest average inhibition zone (13.76 mm). While the extract's efficacy was lower than that of clindamycin (16.66 mm), its potential as a natural antibacterial agent is significant. The findings suggest that cinnamon extract can be developed into a topical treatment for skin infections.
Testing The Effectiveness Of Cinnamon (Cinnamomumm Burmanni Blume) Ethanol Extract Against Salmonella Typhi Bacteria Quppar Siregar, Raja; Aprilyani, Anggi
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 3 (2025): August 2025 (Indonesia - Malaysia)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i3.436

Abstract

Typhoid fever, caused by the bacterium Salmonella Typhi, remains a prevalent infectious disease with increasing antibiotic resistance posing a significant global health threat. This study aimed to investigate the in vitro antibacterial effectiveness of an ethanol extract from cinnamon bark (Cinnamomum burmannii) as a potential natural therapeutic alternative. The research employed a true experimental design with a post-test only control group. A pure culture of Salmonella Typhi was used as the sample. The cinnamon extract was prepared via maceration, and its antibacterial activity was evaluated using the standard Kirby-Bauer disk diffusion method. The inhibition zone diameters were measured and analyzed using non-parametric statistical tests, including Kruskal-Wallis and Mann-Whitney U tests. The results demonstrated that all concentrations (60%, 80%, and 100%) of the cinnamon extract exhibited strong antibacterial activity, with a dose-dependent inhibitory effect. Notably, the 100% extract concentration produced an inhibition zone diameter (15.57 mm) comparable to the positive control, chloramphenicol (15.66 mm). This study concludes that the ethanol extract of Cinnamomum burmannii is an effective antibacterial agent against Salmonella Typhi, providing a promising basis for developing natural therapies.
Co-Authors Lewinssky, Thania Lisa, Elizabeth Quppar Siregar, Raja Suwarno Suwarno