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All Journal Medical Laboratory Technology Journal Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Abdussalam, Arrizqi Hafidh
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Influence of Agricultural Environment on Inflammation and Breast Cancer: A Systematic Review Abdussalam, Arrizqi Hafidh; Permatasari, Happy Kurnia; Sutrisna, EM.; Romadhon, Yusuf Alam; Kurniati, Yuni Prastyo
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5493

Abstract

Purpose: Analyzing the influence of agricultural environment on inflammation and breast cancer. Methodology: PECOS by mentioning terms in MeSH as search keywords. Inclusion criteria include: observational cohort, cross sectional or case control study design. Exclusion criteria included various forms of reviews, experimental design studies, RCTs and in animals, in-vitro studies and in-silico studies. Results: Google Scholar platform search obtained 112 articles and 177 articles from the Scopus database. After identification and screening using PRISMA-P, 6 articles were obtained. Benign and malignant breast lesions were significantly associated with exposure to environmental estrogens including polychlorinated biphenyls (PCBs) and organochlorines. There was an increase in inflammatory biomarkers, namely NF-κB, PPAR-γ, IL-12 dan TNF-α levels in breast lesions from areas with high pesticide spending. Applications: The agricultural environment is a risk factor for breast cancer mediated by inflammatory factors.
Interaction Between Agricultural Environmental Exposure and Inflammatory Biomarkers in Breast Cancer Risk Abdussalam, Arrizqi Hafidh; Kurniati, Yuni Prastyo; Romadhon, Yusuf Alam; Permatasari, Happy Kurnia; Sutrisna, Em
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.675

Abstract

Breast cancer remains the most common malignancy among women worldwide, and environmental exposures may contribute to breast carcinogenesis through inflammatory pathways such as NLR, PLR, and interferon-γ. This study aimed to examine the association between agricultural environmental exposure, represented by rice field area, and inflammatory biomarkers including the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Interferon-γ in breast cancer. A case–control method was applied to 128 histopathologically confirmed samples consisting of 100 malignant (Invasive Carcinoma NST) and 28 benign (Fibroadenoma Mammae) breast tumors; hematologic indices were derived from preoperative blood tests, IFN-γ expression was analyzed immunohistochemically, and rice field proportions near participants’ residences were obtained from national statistics, with data analyzed using Chi-square and multivariate logistic regression. The results showed that agricultural exposure (rice field ≥60%) was not significantly associated with breast cancer (p = 0.703), whereas elevated NLR (OR = 4.89, p = 0.014), PLR (OR = 12.13, p = 0.017), and IFN-γ expression ≥20% (aOR = 23.94, p = 0.049) were significantly associated with malignancy. In conclusion, although agricultural land area was not a direct risk factor, inflammatory and immune biomarkers—particularly IFN-γ—served as strong predictors of breast cancer, indicating their potential utility in risk stratification for agrarian populations.
Co-Authors Em Sutrisna Happy Kurnia Permatasari Yuni Prastyo Kurniati Yusuf Alam Romadhon